Entity Details

Primary name PCSK9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NBP7
EntryNamePCSK9_HUMAN
FullNameProprotein convertase subtilisin/kexin type 9
TaxID9606
Evidenceevidence at protein level
Length692
SequenceStatuscomplete
DateCreated2003-11-07
DateModified2021-06-02

Ontological Relatives

GenesPCSK9

GO terms

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GOName
GO:0001822 kidney development
GO:0001889 liver development
GO:0001920 negative regulation of receptor recycling
GO:0002092 positive regulation of receptor internalization
GO:0003723 RNA binding
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006641 triglyceride metabolic process
GO:0006644 phospholipid metabolic process
GO:0006915 apoptotic process
GO:0007041 lysosomal transport
GO:0008203 cholesterol metabolic process
GO:0009267 cellular response to starvation
GO:0009986 cell surface
GO:0010469 regulation of signaling receptor activity
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0016540 protein autoprocessing
GO:0019871 sodium channel inhibitor activity
GO:0022008 neurogenesis
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0030169 low-density lipoprotein particle binding
GO:0030182 neuron differentiation
GO:0030547 signaling receptor inhibitor activity
GO:0031232 extrinsic component of external side of plasma membrane
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0034185 apolipoprotein binding
GO:0034189 very-low-density lipoprotein particle binding
GO:0034190 apolipoprotein receptor binding
GO:0034383 low-density lipoprotein particle clearance
GO:0036020 endolysosome membrane
GO:0042157 lipoprotein metabolic process
GO:0042632 cholesterol homeostasis
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043621 protein self-association
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048471 perinuclear region of cytoplasm
GO:0050750 low-density lipoprotein particle receptor binding
GO:0070326 very-low-density lipoprotein particle receptor binding
GO:1905596 negative regulation of low-density lipoprotein particle receptor binding
GO:1905598 negative regulation of low-density lipoprotein receptor activity
GO:1905601 negative regulation of receptor-mediated endocytosis involved in cholesterol transport
GO:1990666 PCSK9-LDLR complex
GO:1990667 PCSK9-AnxA2 complex
GO:2000650 negative regulation of sodium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Cell surface
Cytoplasm
Endoplasmic reticulum
Endosome
Golgi apparatus
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR000209 Peptidase S8/S53 domainDomainDomain
IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9DomainDomain
IPR015500 Peptidase S8, subtilisin-relatedFamilyFamily
IPR034193 Proteinase K-like catalytic domainDomainDomain
IPR036852 Peptidase S8/S53 domain superfamilyFamilyHomologous superfamily
IPR037045 Peptidase S8 propeptide/proteinase inhibitor I9 superfamilyFamilyHomologous superfamily
IPR041051 Proprotein convertase subtilisin/kexin type 9, C-terminal domain 3DomainDomain
IPR041052 Proprotein convertase subtilisin/kexin type 9, C-terminal domain 2DomainDomain
IPR041254 Proprotein convertase subtilisin/kexin type 9, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB09302 AlirocumabDrugbankbiotech
DB09303 EvolocumabSwissprotbiotech
DB14901 InclisiranDrugbankbiotech