Entity Details

Primary name CCL21_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00585
EntryNameCCL21_HUMAN
FullNameC-C motif chemokine 21
TaxID9606
Evidenceevidence at protein level
Length134
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCCL21

GO terms

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GOName
GO:0001768 establishment of T cell polarity
GO:0001771 immunological synapse formation
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002407 dendritic cell chemotaxis
GO:0002548 monocyte chemotaxis
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008009 chemokine activity
GO:0010560 positive regulation of glycoprotein biosynthetic process
GO:0010820 positive regulation of T cell chemotaxis
GO:0030593 neutrophil chemotaxis
GO:0030838 positive regulation of actin filament polymerization
GO:0031274 positive regulation of pseudopodium assembly
GO:0031295 T cell costimulation
GO:0031529 ruffle organization
GO:0031640 killing of cells of other organism
GO:0031732 CCR7 chemokine receptor binding
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0034695 response to prostaglandin E
GO:0035759 mesangial cell-matrix adhesion
GO:0038116 chemokine (C-C motif) ligand 21 signaling pathway
GO:0042379 chemokine receptor binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043547 positive regulation of GTPase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045860 positive regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0048020 CCR chemokine receptor binding
GO:0048245 eosinophil chemotaxis
GO:0048247 lymphocyte chemotaxis
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048469 cell maturation
GO:0050921 positive regulation of chemotaxis
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051491 positive regulation of filopodium assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0090630 activation of GTPase activity
GO:0097026 dendritic cell dendrite assembly
GO:1903237 negative regulation of leukocyte tethering or rolling
GO:1990869 cellular response to chemokine
GO:2000147 positive regulation of cell motility
GO:2000406 positive regulation of T cell migration
GO:2000529 positive regulation of myeloid dendritic cell chemotaxis
GO:2000548 negative regulation of dendritic cell dendrite assembly
GO:2000669 negative regulation of dendritic cell apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001811 Chemokine interleukin-8-like domainDomainDomain
IPR030593 C-C motif chemokine 21FamilyFamily
IPR034133 Chemokine CC, DCCL motif-cointaining domainDomainDomain
IPR036048 Chemokine interleukin-8-like superfamilyFamilyHomologous superfamily
IPR039809 Chemokine beta/gamma/deltaFamilyFamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
CCL21_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16713569 details
CCL21_HUMANAATM_HUMANBioGRID, MINT21900206 details
CCL21_HUMANLRRK1_HUMANBioGRID, IntAct24947832 29513927 details
CCL21_HUMANLRRK2_HUMANIntAct24947832 details
CCL21_HUMANTTMP_HUMANBioGRID, IntAct32296183 details
CCL21_HUMANOTP_HUMANBioGRID, IntAct32296183 details
CCL21_HUMANTM107_HUMANBioGRID, IntAct32296183 details
CCL21_HUMANCCL5_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANPLF4_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANSDF1_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCCL17_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCCL13_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCXCL9_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCXCL7_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANXCL1_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCCL28_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCCL26_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCCL23_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANPF4V_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCCL24_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCXL14_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCXL10_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCXCL2_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANXCL2_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCXL11_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANCXL17_HUMANbhf-ucl, BioGRID28381538 details
CCL21_HUMANJPH3_HUMANIntAct32814053 details
CCL21_HUMANCSPG2_HUMANBioGRID, HPRD11083865 details
CCL21_HUMANACKR4_HUMANBioGRID, HPRD10706668 details
CCL21_HUMANCCR7_HUMANHPRD, Molecular Connections21172016 9507024 9585422 details
CCL21_HUMANIBP7_HUMANHPRD12847218 details
CCL21_HUMANACKR2_HUMANHPRD10706668 details
CCL21_HUMANCATD_HUMANHPRD12651610 details
CCL21_HUMANCXL13_HUMANHPRD15546958 details