Entity Details

Primary name PIWL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TC59
EntryNamePIWL2_HUMAN
FullNamePiwi-like protein 2
TaxID9606
Evidenceevidence at protein level
Length973
SequenceStatuscomplete
DateCreated2006-05-16
DateModified2021-06-02

Ontological Relatives

GenesPIWIL2

GO terms

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GOName
GO:0000966 RNA 5'-end processing
GO:0003729 mRNA binding
GO:0004521 endoribonuclease activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0010370 perinucleolar chromocenter
GO:0010529 negative regulation of transposition
GO:0030718 germ-line stem cell population maintenance
GO:0031047 gene silencing by RNA
GO:0033391 chromatoid body
GO:0034584 piRNA binding
GO:0034587 piRNA metabolic process
GO:0042754 negative regulation of circadian rhythm
GO:0043046 DNA methylation involved in gamete generation
GO:0043186 P granule
GO:0045727 positive regulation of translation
GO:0046872 metal ion binding
GO:0048477 oogenesis
GO:0048511 rhythmic process
GO:0051321 meiotic cell cycle
GO:0060903 positive regulation of meiosis I
GO:0071442 positive regulation of histone H3-K14 acetylation
GO:0071546 pi-body
GO:0097433 dense body
GO:1905538 polysome binding
GO:1990511 piRNA biosynthetic process
GO:1990923 PET complex
GO:2000617 positive regulation of histone H3-K9 acetylation

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003100 PAZ domainDomainDomain
IPR003165 Piwi domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR014811 Argonaute, linker 1 domainDomainDomain
IPR036085 PAZ domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily

Diseases

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