Entity Details

Primary name MA2B1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00754
EntryNameMA2B1_HUMAN
FullNameLysosomal alpha-mannosidase
TaxID9606
Evidenceevidence at protein level
Length1011
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesMAN2B1

GO terms

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GOName
GO:0004559 alpha-mannosidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005764 lysosome
GO:0005774 vacuolar membrane
GO:0006013 mannose metabolic process
GO:0006464 cellular protein modification process
GO:0006517 protein deglycosylation
GO:0009313 oligosaccharide catabolic process
GO:0030246 carbohydrate binding
GO:0035578 azurophil granule lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0046872 metal ion binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Lysosome

Domains

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DomainNameCategoryType
IPR000602 Glycoside hydrolase family 38, N-terminal domainDomainDomain
IPR011013 Galactose mutarotase-like domain superfamilyFamilyHomologous superfamily
IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrelFamilyHomologous superfamily
IPR011682 Glycosyl hydrolase family 38, C-terminalDomainDomain
IPR013780 Glycosyl hydrolase, all-betaFamilyHomologous superfamily
IPR015341 Glycoside hydrolase family 38, central domainDomainDomain
IPR027291 Glycoside hydrolase 38, N-terminal domain superfamilyFamilyHomologous superfamily
IPR028995 Glycoside hydrolase families 57/38, central domain superfamilyFamilyHomologous superfamily
IPR037094 Glycoside hydrolase family 38, central domain superfamilyFamilyHomologous superfamily
IPR041147 Glycosyl hydrolases family 38, C-terminal beta sandwich domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MA2B1_HUMANNKX31_HUMANBioGRID18816836 details
MA2B1_HUMANSMAD9_HUMANHPRD15231748 details