Entity Details

Primary name DDX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92499
EntryNameDDX1_HUMAN
FullNameATP-dependent RNA helicase DDX1
TaxID9606
Evidenceevidence at protein level
Length740
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesDDX1

GO terms

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GOName
GO:0000245 spliceosomal complex assembly
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003712 transcription coregulator activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006446 regulation of translational initiation
GO:0007275 multicellular organism development
GO:0008143 poly(A) binding
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0016032 viral process
GO:0032508 DNA duplex unwinding
GO:0033677 DNA/RNA helicase activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:0071920 cleavage body
GO:0072669 tRNA-splicing ligase complex
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:1903608 protein localization to cytoplasmic stress granule
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic granule
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR001870 B30.2/SPRY domainDomainDomain
IPR003877 SPRY domainDomainDomain
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014014 RNA helicase, DEAD-box type, Q motifDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
DDX1_HUMANNDK7_HUMANBioGRID, IntAct21988832 details
DDX1_HUMANHNRPK_HUMANBioGRID, HPRD12183465 details
DDX1_HUMANATM_HUMANBioGRID18710941 details
DDX1_HUMANA4_HUMANBioGRID21832049 details
DDX1_HUMAN1433T_HUMANBioGRID15161933 details
DDX1_HUMANESR1_HUMANBioGRID20348541 details
DDX1_HUMANPTEN_HUMANBioGRID31685992 details
DDX1_HUMANSUMO2_HUMANBioGRID32786267 details
DDX1_HUMANTF65_HUMANHPRD19058135 details
DDX1_HUMANRELB_HUMANIntAct14743216 details
DDX1_HUMAN1433Z_HUMANMINT15161933 details
DDX1_HUMANSMAD2_HUMANIntAct20195357 details
DDX1_HUMANYBOX1_HUMANBioGRID, HPIDb22863883 24965446 details
DDX1_HUMANANKS6_HUMANBioGRID, IntAct27173435 unassigned1312 details
DDX1_HUMANHDAC1_HUMANBioGRID, IntAct27173435 unassigned1312 details
DDX1_HUMANRFX3_HUMANBioGRID, IntAct27173435 unassigned1312 details
DDX1_HUMANXYLT2_HUMANBioGRID, IntAct27173435 unassigned1312 details
DDX1_HUMANRTCB_HUMANBioGRID, IntAct, UniProt22863883 22939629 24608264 24981860 26344197 27173435 29395067 30833792 unassigned1312 details
DDX1_HUMANFA98A_HUMANBioGRID, UniProt26344197 28040436 29395067 29992460 details
DDX1_HUMANCSTF2_HUMANBioGRID, HPRD11598190 22939629 details
DDX1_HUMANMRE11_HUMANBioGRID18710941 22863883 details
DDX1_HUMANRAD50_HUMANBioGRID18710941 details
DDX1_HUMANNBN_HUMANBioGRID18710941 details
DDX1_HUMANSRRM2_HUMANBioGRID16159877 details
DDX1_HUMANHDAC5_HUMANBioGRID21081666 details
DDX1_HUMANITA4_HUMANBioGRID22623428 details
DDX1_HUMANCTNB1_HUMANBioGRID16230076 27684187 details
DDX1_HUMANSH3R2_HUMANBioGRID24130170 details
DDX1_HUMANZBTB1_HUMANBioGRID24657165 details
DDX1_HUMANMAEL_HUMANBioGRID24189637 details
DDX1_HUMANKC1A_HUMANBioGRID29593330 details
DDX1_HUMANRIF1_HUMANBioGRID28544931 details
DDX1_HUMANERPG3_HUMANBioGRID26030138 details
DDX1_HUMANERCC6_HUMANBioGRID26030138 details
DDX1_HUMANSOX2_HUMANBioGRID21280222 details
DDX1_HUMANANM8_HUMANBioGRID18320585 details
DDX1_HUMANMEX3B_HUMANBioGRID29395067 details
DDX1_HUMANNUFP2_HUMANBioGRID29395067 details
DDX1_HUMANPUM1_HUMANBioGRID29395067 details
DDX1_HUMANR3HD2_HUMANBioGRID29395067 details
DDX1_HUMANRBMS1_HUMANBioGRID29395067 details
DDX1_HUMANTDRD3_HUMANBioGRID29395067 details
DDX1_HUMANUBP2L_HUMANBioGRID29395067 details
DDX1_HUMANUBP10_HUMANBioGRID29395067 details
DDX1_HUMANYTHD3_HUMANBioGRID29395067 details
DDX1_HUMANFXR1_HUMANBioGRID29395067 details
DDX1_HUMANISG15_HUMANBioGRID33024031 details