Entity Details

Primary name TOP1M_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ969P6
EntryNameTOP1M_HUMAN
FullNameDNA topoisomerase I, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length601
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesTOP1MT

GO terms

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GOName
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005739 mitochondrion
GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0042645 mitochondrial nucleoid

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR001631 DNA topoisomerase IFamilyFamily
IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-typeDomainDomain
IPR011010 DNA breaking-rejoining enzyme, catalytic coreFamilyHomologous superfamily
IPR013030 DNA topoisomerase I, DNA binding, N-terminal domain 2FamilyHomologous superfamily
IPR013034 DNA topoisomerase I, DNA binding, N-terminal domain 1FamilyHomologous superfamily
IPR013499 DNA topoisomerase I, eukaryotic-typeDomainDomain
IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-typeDomainDomain
IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-typeFamilyHomologous superfamily
IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomainFamilyHomologous superfamily
IPR018521 DNA topoisomerase I, active siteSiteActive site
IPR025834 Topoisomerase I C-terminal domainDomainDomain
IPR036202 DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00762 IrinotecanDrugbanksmall molecule
DB01030 TopotecanDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TOP1M_HUMANP53_HUMANBioGRID, IntAct25402006 details