Entity Details

Primary name APAF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14727
EntryNameAPAF_HUMAN
FullNameApoptotic protease-activating factor 1
TaxID9606
Evidenceevidence at protein level
Length1248
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesAPAF1

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0001666 response to hypoxia
GO:0001822 kidney development
GO:0001843 neural tube closure
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007399 nervous system development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010659 cardiac muscle cell apoptotic process
GO:0030154 cell differentiation
GO:0030900 forebrain development
GO:0031072 heat shock protein binding
GO:0032991 protein-containing complex
GO:0034774 secretory granule lumen
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043293 apoptosome
GO:0043312 neutrophil degranulation
GO:0043531 ADP binding
GO:0051402 neuron apoptotic process
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070062 extracellular exosome
GO:0070317 negative regulation of G0 to G1 transition
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072432 response to G1 DNA damage checkpoint signaling
GO:0097193 intrinsic apoptotic signaling pathway
GO:1902510 regulation of apoptotic DNA fragmentation
GO:1904813 ficolin-1-rich granule lumen
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR001680 WD40 repeatRepeatRepeat
IPR002182 NB-ARCDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR017251 Apoptotic protease-activating factor 1FamilyFamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037963 Apoptotic Protease-Activating Factor 1, CARD domainDomainDomain
IPR041452 APAF-1 helical domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule

Interactions

25 interactions

InteractorPartnerSourcesPublicationsLink
APAF_HUMANCASP9_HUMANBioGRID, DIP, HPRD, IntAct, MINT10206961 10376594 11113115 11242052 15262985 16979168 19494828 19698783 20462491 20829884 21060833 21827945 27197231 27476169 28716524 9390557 9488720 9539746 9837928 9922454 details
APAF_HUMANAVEN_HUMANBioGRID, HPRD, MINT10949025 details
APAF_HUMANCASP3_HUMANHPRD, IntAct, MINT11550094 21827945 details
APAF_HUMANPP1A_HUMANBioGRID, HPRD, IntAct17274640 details
APAF_HUMANMTNB_HUMANBioGRID, HPRD15262985 details
APAF_HUMANHSP74_HUMANBioGRID10934467 22143029 31577950 details
APAF_HUMANHS90A_HUMANBioGRID10934467 15001356 details
APAF_HUMANB2CL1_HUMANBioGRID, HPRD12963020 9488720 9539746 details
APAF_HUMANTOP1_HUMANBioGRID12549820 details
APAF_HUMANB2L10_HUMANHPRD10486928 9829980 9878060 details
APAF_HUMANHS71A_HUMANHPRD, MINT10934467 details
APAF_HUMANHS71B_HUMANHPRD, MINT10934467 details
APAF_HUMANCYC_HUMANBioGRID, HPRD, IntAct10206961 12147322 16979168 9267021 details
APAF_HUMAN1433E_HUMANMINT22246185 details
APAF_HUMANNLRP1_HUMANBioGRID, HPRD11113115 17418785 details
APAF_HUMANCASP4_HUMANBioGRID, HPRD9539746 details
APAF_HUMANCASP8_HUMANBioGRID, HPRD9539746 details
APAF_HUMANTRIA1_HUMANBioGRID, HPRD15735003 details
APAF_HUMANXIAP_HUMANBioGRID11242052 19698783 details
APAF_HUMANENPL_HUMANBioGRID25737303 details
APAF_HUMANHIP1_HUMANBioGRID, HPRD16979168 details
APAF_HUMANCUL4B_HUMANBioGRID31329620 details
APAF_HUMANSQSTM_HUMANBioGRID31329620 details
APAF_HUMANFEM1B_HUMANHPRD10764728 details
APAF_HUMANTNR6_HUMANHPRD9267021 details