Entity Details

Primary name RGRF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14827
EntryNameRGRF2_HUMAN
FullNameRas-specific guanine nucleotide-releasing factor 2
TaxID9606
Evidenceevidence at protein level
Length1237
SequenceStatuscomplete
DateCreated2007-12-04
DateModified2021-06-02

Ontological Relatives

GenesRASGRF2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005516 calmodulin binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0034976 response to endoplasmic reticulum stress
GO:0035023 regulation of Rho protein signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0060291 long-term synaptic potentiation
GO:2000310 regulation of NMDA receptor activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000048 IQ motif, EF-hand binding siteSiteBinding site
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019804 Ras guanine-nucleotide exchange factor, conserved siteSiteConserved site
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR030744 Ras-specific guanine nucleotide-releasing factor 2FamilyFamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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