Entity Details

Primary name FERM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BQL6
EntryNameFERM1_HUMAN
FullNameFermitin family homolog 1
TaxID9606
Evidenceevidence at protein level
Length677
SequenceStatuscomplete
DateCreated2002-12-06
DateModified2021-06-02

Ontological Relatives

GenesFERMT1

GO terms

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GOName
GO:0001954 positive regulation of cell-matrix adhesion
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0010629 negative regulation of gene expression
GO:0030054 cell junction
GO:0030055 cell-substrate junction
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032587 ruffle membrane
GO:0033625 positive regulation of integrin activation
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0042308 negative regulation of protein import into nucleus
GO:0043616 keratinocyte proliferation
GO:0051015 actin filament binding
GO:0051546 keratinocyte migration
GO:0051886 negative regulation of timing of anagen
GO:0071636 positive regulation of transforming growth factor beta production
GO:0071711 basement membrane organization
GO:0071944 cell periphery
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090162 establishment of epithelial cell polarity
GO:1903691 positive regulation of wound healing, spreading of epidermal cells
GO:2000647 negative regulation of stem cell proliferation

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR037837 Kindlin/fermitin, PH domainDomainDomain
IPR037843 Kindlin/fermitinFamilyFamily
IPR040790 Kindlin-2, N-terminalDomainDomain

Diseases

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Interactions

4 interactions