Entity Details

Primary name SHAN3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BYB0
EntryNameSHAN3_HUMAN
FullNameSH3 and multiple ankyrin repeat domains protein 3
TaxID9606
Evidenceevidence at protein level
Length1731
SequenceStatuscomplete
DateCreated2002-07-26
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0003779 actin binding
GO:0005829 cytosol
GO:0007411 axon guidance
GO:0007416 synapse assembly
GO:0007612 learning
GO:0007613 memory
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0014069 postsynaptic density
GO:0017124 SH3 domain binding
GO:0021773 striatal medium spiny neuron differentiation
GO:0030160 synaptic receptor adaptor activity
GO:0030534 adult behavior
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032232 negative regulation of actin filament bundle assembly
GO:0035176 social behavior
GO:0035255 ionotropic glutamate receptor binding
GO:0042297 vocal learning
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0043621 protein self-association
GO:0044309 neuron spine
GO:0045794 negative regulation of cell volume
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048854 brain morphogenesis
GO:0051124 synaptic assembly at neuromuscular junction
GO:0051835 positive regulation of synapse structural plasticity
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060170 ciliary membrane
GO:0060291 long-term synaptic potentiation
GO:0060997 dendritic spine morphogenesis
GO:0060999 positive regulation of dendritic spine development
GO:0061001 regulation of dendritic spine morphogenesis
GO:0071625 vocalization behavior
GO:0097107 postsynaptic density assembly
GO:0097110 scaffold protein binding
GO:0097113 AMPA glutamate receptor clustering
GO:0097114 NMDA glutamate receptor clustering
GO:0097117 guanylate kinase-associated protein clustering
GO:1900271 regulation of long-term synaptic potentiation
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1900451 positive regulation of glutamate receptor signaling pathway
GO:1900452 regulation of long-term synaptic depression
GO:2000311 regulation of AMPA receptor activity
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000969 positive regulation of AMPA receptor activity

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR001660 Sterile alpha motif domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR041489 PDZ domain 6DomainDomain

Diseases

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Disease IDSourceNameDescription
606232 OMIMPhelan-McDermid syndrome (PHMDS)A developmental disorder with variable features. Common features include neonatal hypotonia, global developmental delay, normal to accelerated growth, absent to severely delayed speech, autistic behavior, and minor dysmorphic features. The disease is caused by variants affecting the gene represented in this entry.
613950 OMIMSchizophrenia 15 (SCZD15)A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. The disease is caused by variants affecting the gene represented in this entry.

Interactions

166 interactions

InteractorPartnerSourcesPublicationsLink
SHAN3_HUMANPLCG1_HUMANIntAct17474147 details
SHAN3_HUMANABL1_HUMANIntAct17474147 details
SHAN3_HUMANCRK_HUMANIntAct17474147 details
SHAN3_HUMANSRC_HUMANIntAct17474147 details
SHAN3_HUMANFYN_HUMANIntAct17474147 details
SHAN3_HUMANGRB2_HUMANIntAct17474147 21988832 details
SHAN3_HUMANNCK1_HUMANIntAct17474147 21988832 details
SHAN3_HUMANP85A_HUMANIntAct17474147 details
SHAN3_HUMANMRP2_HUMANIntAct21988832 details
SHAN3_HUMANCRKL_HUMANIntAct21988832 details
SHAN3_HUMANCSK2B_HUMANIntAct21988832 details
SHAN3_HUMANMK01_HUMANIntAct21988832 details
SHAN3_HUMANCSN5_HUMANIntAct21988832 details
SHAN3_HUMANBI2L1_HUMANDIP21098279 details
SHAN3_HUMANCAC1D_HUMANUniProt30058071 details
SHAN3_HUMANDLGP1_HUMANMINT20573181 21653829 details
SHAN3_HUMANANM2_HUMANIntAct, MINT21653829 28514442 details
SHAN3_HUMANMIC19_HUMANIntAct30021884 details
SHAN3_HUMANPRC1_HUMANIntAct30021884 details
SHAN3_HUMANACTN1_HUMANMINT21653829 details
SHAN3_HUMANARHG7_HUMANMINT21653829 details
SHAN3_HUMANFLNA_HUMANMINT21653829 details
SHAN3_HUMANHNRPC_HUMANMINT21653829 details
SHAN3_HUMANKHDR3_HUMANMINT21653829 details
SHAN3_HUMANPICK1_HUMANMINT21653829 details
SHAN3_HUMANNELL2_HUMANMINT21653829 details
SHAN3_HUMANPSMD4_HUMANMINT21653829 details
SHAN3_HUMANSIR2_HUMANMINT21653829 details
SHAN3_HUMANACTN2_HUMANMINT21653829 details
SHAN3_HUMANABI2_HUMANMINT21653829 details
SHAN3_HUMANABI1_HUMANMINT21653829 details
SHAN3_HUMANATN1_HUMANMINT21653829 details
SHAN3_HUMANBAIP2_HUMANMINT21653829 details
SHAN3_HUMANARPC2_HUMANMINT21653829 details
SHAN3_HUMANA4_HUMANMINT21653829 details
SHAN3_HUMANANR35_HUMANMINT21653829 details
SHAN3_HUMANALDOA_HUMANMINT21653829 details
SHAN3_HUMANAGAP7_HUMANMINT21653829 details
SHAN3_HUMANDLGP2_HUMANMINT21653829 details
SHAN3_HUMANDDB1_HUMANMINT21653829 details
SHAN3_HUMANDCTN2_HUMANMINT21653829 details
SHAN3_HUMANDBNL_HUMANMINT21653829 details
SHAN3_HUMANCYTIP_HUMANMINT21653829 details
SHAN3_HUMANCP51A_HUMANMINT21653829 details
SHAN3_HUMANSRC8_HUMANMINT21653829 details
SHAN3_HUMANKC1D_HUMANMINT21653829 details
SHAN3_HUMANCREL1_HUMANMINT21653829 details
SHAN3_HUMANCOQ5_HUMANMINT21653829 details
SHAN3_HUMANCSN6_HUMANMINT21653829 details
SHAN3_HUMANCLUS_HUMANMINT21653829 details
SHAN3_HUMANCLCA_HUMANMINT21653829 details
SHAN3_HUMANCEP72_HUMANMINT21653829 details
SHAN3_HUMANCENPJ_HUMANMINT21653829 details
SHAN3_HUMANTCPG_HUMANMINT21653829 details
SHAN3_HUMANKCC2B_HUMANMINT21653829 details
SHAN3_HUMANCACO1_HUMANMINT21653829 details
SHAN3_HUMANCAH10_HUMANMINT21653829 details
SHAN3_HUMANLRC73_HUMANMINT21653829 details
SHAN3_HUMANC1QBP_HUMANMINT21653829 details
SHAN3_HUMANARP5L_HUMANMINT21653829 details
SHAN3_HUMANMBOA7_HUMANMINT21653829 details
SHAN3_HUMANMBIP1_HUMANMINT21653829 details
SHAN3_HUMANLZTS2_HUMANMINT21653829 details
SHAN3_HUMANLTBP4_HUMANMINT21653829 details
SHAN3_HUMANLTBP3_HUMANMINT21653829 details
SHAN3_HUMANAGRL1_HUMANMINT21653829 details
SHAN3_HUMANLIGO1_HUMANMINT21653829 details
SHAN3_HUMANK0232_HUMANMINT21653829 details
SHAN3_HUMANJAG2_HUMANMINT21653829 details
SHAN3_HUMANITSN1_HUMANMINT21653829 details
SHAN3_HUMANITGBL_HUMANMINT21653829 details
SHAN3_HUMANTUTLA_HUMANMINT21653829 details
SHAN3_HUMANICA69_HUMANMINT21653829 details
SHAN3_HUMANHOME3_HUMANMINT21653829 details
SHAN3_HUMANHNRPK_HUMANMINT21653829 details
SHAN3_HUMANHGS_HUMANMINT21653829 details
SHAN3_HUMANHECW1_HUMANMINT21653829 details
SHAN3_HUMANGLO2_HUMANMINT21653829 details
SHAN3_HUMANGRN_HUMANMINT21653829 details
SHAN3_HUMANCSN1_HUMANMINT21653829 details
SHAN3_HUMANGP162_HUMANMINT21653829 details
SHAN3_HUMANAATC_HUMANMINT21653829 details
SHAN3_HUMANFRYL_HUMANMINT21653829 details
SHAN3_HUMANFRS3_HUMANMINT21653829 details
SHAN3_HUMANFKBP8_HUMANMINT21653829 details
SHAN3_HUMANFBX7_HUMANMINT21653829 details
SHAN3_HUMANFA92A_HUMANMINT21653829 details
SHAN3_HUMANFA13A_HUMANMINT21653829 details
SHAN3_HUMANERI3_HUMANMINT21653829 details
SHAN3_HUMANELAV1_HUMANMINT21653829 details
SHAN3_HUMANEID1_HUMANMINT21653829 details
SHAN3_HUMANFBLN4_HUMANMINT21653829 details
SHAN3_HUMANFBLN3_HUMANMINT21653829 details
SHAN3_HUMANDYN2_HUMANMINT21653829 details
SHAN3_HUMANDNJA3_HUMANMINT21653829 details
SHAN3_HUMANDLGP4_HUMANMINT21653829 details
SHAN3_HUMANDLGP3_HUMANMINT21653829 details
SHAN3_HUMANG3P_HUMANMINT21653829 details
SHAN3_HUMANNU6M_HUMANMINT21653829 details
SHAN3_HUMANCOX2_HUMANMINT21653829 details
SHAN3_HUMANMIPO1_HUMANMINT21653829 details
SHAN3_HUMANMEGF6_HUMANMINT21653829 details
SHAN3_HUMANMEG11_HUMANMINT21653829 details
SHAN3_HUMANMEG10_HUMANMINT21653829 details
SHAN3_HUMANMDHM_HUMANMINT21653829 details
SHAN3_HUMANMCRS1_HUMANMINT21653829 details
SHAN3_HUMANN4BP3_HUMANMINT21653829 details
SHAN3_HUMANSPN90_HUMANMINT21653829 details
SHAN3_HUMANNFL_HUMANMINT21653829 details
SHAN3_HUMANNGRN_HUMANMINT21653829 details
SHAN3_HUMANNOTC2_HUMANMINT21653829 details
SHAN3_HUMANMYO5B_HUMANMINT21653829 details
SHAN3_HUMANHRG1_HUMANMINT21653829 details
SHAN3_HUMANSIPA1_HUMANMINT21653829 details
SHAN3_HUMANSHRPN_HUMANMINT21653829 details
SHAN3_HUMANSHAN1_HUMANMINT21653829 details
SHAN3_HUMANSH3G3_HUMANMINT21653829 details
SHAN3_HUMANSH3G2_HUMANMINT21653829 details
SHAN3_HUMANSRSF9_HUMANMINT21653829 details
SHAN3_HUMANSETD2_HUMANMINT21653829 details
SHAN3_HUMANPACE1_HUMANMINT21653829 details
SHAN3_HUMANRUN3A_HUMANMINT21653829 details
SHAN3_HUMANRTN3_HUMANMINT21653829 details
SHAN3_HUMANRL3_HUMANMINT21653829 details
SHAN3_HUMANMRM3_HUMANMINT21653829 details
SHAN3_HUMANRHG44_HUMANMINT21653829 details
SHAN3_HUMANRBM5_HUMANMINT21653829 details
SHAN3_HUMANQSOX1_HUMANMINT21653829 details
SHAN3_HUMANLZTS3_HUMANMINT21653829 details
SHAN3_HUMANP2R3B_HUMANMINT21653829 details
SHAN3_HUMANNEB2_HUMANMINT21653829 details
SHAN3_HUMANIASPP_HUMANMINT21653829 details
SHAN3_HUMANPPHLN_HUMANMINT21653829 details
SHAN3_HUMANPKHA4_HUMANMINT21653829 details
SHAN3_HUMANPHLB1_HUMANMINT21653829 details
SHAN3_HUMANPHF12_HUMANMINT21653829 details
SHAN3_HUMANPFKAL_HUMANMINT21653829 details
SHAN3_HUMANODPB_HUMANMINT21653829 details
SHAN3_HUMANNRBF2_HUMANMINT21653829 details
SHAN3_HUMANNR1D1_HUMANMINT21653829 details
SHAN3_HUMANNOTC3_HUMANMINT21653829 details
SHAN3_HUMANNT2NA_HUMANMINT21653829 details
SHAN3_HUMANRSMN_HUMANMINT21653829 details
SHAN3_HUMANSRBS2_HUMANMINT21653829 details
SHAN3_HUMANTANK_HUMANMINT21653829 details
SHAN3_HUMANSPAG5_HUMANMINT21653829 details
SHAN3_HUMANST32C_HUMANMINT21653829 details
SHAN3_HUMANSYGP1_HUMANMINT21653829 details
SHAN3_HUMANSYT5_HUMANMINT21653829 details
SHAN3_HUMANTCF25_HUMANMINT21653829 details
SHAN3_HUMANTRAF3_HUMANMINT21653829 details
SHAN3_HUMANTNIP2_HUMANMINT21653829 details
SHAN3_HUMANTDRD7_HUMANMINT21653829 details
SHAN3_HUMANTR150_HUMANMINT21653829 details
SHAN3_HUMANTFP11_HUMANMINT21653829 details
SHAN3_HUMANTM14C_HUMANMINT21653829 details
SHAN3_HUMANUCHL1_HUMANMINT21653829 details
SHAN3_HUMANTBA1C_HUMANMINT21653829 details
SHAN3_HUMANTS101_HUMANMINT21653829 details
SHAN3_HUMANCIP4_HUMANMINT21653829 details
SHAN3_HUMANTRIM9_HUMANMINT21653829 details
SHAN3_HUMANTRI27_HUMANMINT21653829 details
SHAN3_HUMANZCHC2_HUMANMINT21653829 details
SHAN3_HUMANWWP1_HUMANMINT21653829 details
SHAN3_HUMANVPS18_HUMANMINT21653829 details
SHAN3_HUMANVIME_HUMANMINT21653829 details