Entity Details

Primary name HRH4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H3N8
EntryNameHRH4_HUMAN
FullNameHistamine H4 receptor
TaxID9606
Evidenceevidence at protein level
Length390
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesHRH4

GO terms

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GOName
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 chemical synaptic transmission
GO:0016907 G protein-coupled acetylcholine receptor activity
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0043408 regulation of MAPK cascade
GO:0045202 synapse

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR008102 Histamine H4 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00321 AmitriptylineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01620 PheniramineDrugbanksmall molecule
DB05032 REV131Drugbanksmall molecule
DB05381 HistamineDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule