Entity Details

Primary name ECT2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H8V3
EntryNameECT2_HUMAN
FullNameProtein ECT2
TaxID9606
Evidenceevidence at protein level
Length914
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesECT2

GO terms

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GOName
GO:0000281 mitotic cytokinesis
GO:0000902 cell morphogenesis
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0005923 bicellular tight junction
GO:0005938 cell cortex
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007399 nervous system development
GO:0015031 protein transport
GO:0016604 nuclear body
GO:0030154 cell differentiation
GO:0030496 midbody
GO:0031267 small GTPase binding
GO:0032147 activation of protein kinase activity
GO:0032154 cleavage furrow
GO:0032467 positive regulation of cytokinesis
GO:0035556 intracellular signal transduction
GO:0042307 positive regulation of protein import into nucleus
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043547 positive regulation of GTPase activity
GO:0045666 positive regulation of neuron differentiation
GO:0045859 regulation of protein kinase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051260 protein homooligomerization
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0070301 cellular response to hydrogen peroxide
GO:0070830 bicellular tight junction assembly
GO:0071277 cellular response to calcium ion
GO:0071479 cellular response to ionizing radiation
GO:0072686 mitotic spindle
GO:0090630 activation of GTPase activity
GO:0097149 centralspindlin complex
GO:2000431 regulation of cytokinesis, actomyosin contractile ring assembly

Subcellular Location

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Subcellular Location
Cell junction
Cleavage furrow
Cytoplasm
Midbody
Nucleus

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001357 BRCT domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR026817 Guanine nucleotide exchange factor Ect2FamilyFamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
ECT2_HUMANGRB2_HUMANIntAct17474147 details
ECT2_HUMANIF4A2_HUMANBioGRID22990118 31586073 details
ECT2_HUMANNPC2_HUMANBioGRID22990118 details
ECT2_HUMANFANCM_HUMANBioGRID22990118 details
ECT2_HUMANOOSP2_HUMANBioGRID22990118 details
ECT2_HUMANCOX2_HUMANBioGRID22990118 details
ECT2_HUMANIF2P_HUMANBioGRID22990118 31586073 details
ECT2_HUMANPAR3_HUMANHPRD15254234 details
ECT2_HUMANKLH20_HUMANBioGRID, HPRD14668487 17395875 details
ECT2_HUMANRS20_HUMANBioGRID22990118 31586073 details
ECT2_HUMANERAL1_HUMANBioGRID22990118 details
ECT2_HUMANRGAP1_HUMANBioGRID, DIP, HPRD, MINT18201571 19468300 19468302 22750944 25068414 25486482 31586073 details
ECT2_HUMANLTOR5_HUMANBioGRID, IntAct23414517 details
ECT2_HUMANPLK4_HUMANDIP20348415 details
ECT2_HUMANPOMP_HUMANBioGRID22990118 details
ECT2_HUMANTHA11_HUMANBioGRID22990118 details
ECT2_HUMANELOC_HUMANBioGRID22990118 details
ECT2_HUMANPAR6A_HUMANBioGRID, HPRD15254234 details
ECT2_HUMANSRPK2_HUMANBioGRID26167880 details
ECT2_HUMANMT2_HUMANBioGRID22990118 details
ECT2_HUMANPSA6_HUMANBioGRID22990118 details
ECT2_HUMANCCD91_HUMANBioGRID22990118 details
ECT2_HUMANUBP7_HUMANBioGRID32929379 details
ECT2_HUMANHACL2_HUMANBioGRID22990118 details
ECT2_HUMANU520_HUMANBioGRID22990118 31586073 details
ECT2_HUMANMBD1_HUMANBioGRID22990118 details
ECT2_HUMANSPT22_HUMANBioGRID22990118 details
ECT2_HUMANNOMO1_HUMANBioGRID22990118 details
ECT2_HUMANCYTB_HUMANBioGRID22990118 details
ECT2_HUMANCHSTA_HUMANBioGRID22990118 details
ECT2_HUMANNCK1_HUMANIntAct17474147 details
ECT2_HUMANP85A_HUMANIntAct17474147 details
ECT2_HUMANVDAC2_HUMANBioGRID22990118 31586073 details
ECT2_HUMANCB042_HUMANBioGRID22990118 details
ECT2_HUMANABR_HUMANBioGRID22990118 details
ECT2_HUMANCD19_HUMANBioGRID22990118 details
ECT2_HUMANGGN_HUMANBioGRID22990118 details
ECT2_HUMANPCOC1_HUMANBioGRID22990118 details
ECT2_HUMANUBB_HUMANBioGRID22990118 details
ECT2_HUMANOTUB1_HUMANBioGRID22990118 details
ECT2_HUMANNPHP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
ECT2_HUMANKIF23_HUMANBioGRID, DIP19468300 22750944 31586073 details
ECT2_HUMANWDR5_HUMANBioGRID25666610 details
ECT2_HUMANNPM_HUMANBioGRID31586073 32929379 details
ECT2_HUMANNUCL_HUMANBioGRID31586073 32929379 details
ECT2_HUMANSRSF5_HUMANBioGRID31586073 32929379 details
ECT2_HUMANFTM_HUMANBioGRID, IntAct26638075 27173435 unassigned1312 details
ECT2_HUMANCADH1_HUMANBioGRID, DIP21886810 22750944 details
ECT2_HUMANPLK1_HUMANHPRD16247472 details
ECT2_HUMANCTNA1_HUMANDIP22750944 details
ECT2_HUMANTBA1A_HUMANBioGRID25486481 32929379 details
ECT2_HUMANTRIPC_HUMANBioGRID32929379 details
ECT2_HUMANPARD3_HUMANBioGRID15254234 details
ECT2_HUMANECT2_HUMANBioGRID31586073 32929379 details
ECT2_HUMANGKAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
ECT2_HUMANMYC_HUMANBioGRID, IntAct17353931 29467282 details
ECT2_HUMANSIR1_HUMANBioGRID22990118 31502386 32929379 details
ECT2_HUMANRL6_HUMANBioGRID31586073 32929379 details
ECT2_HUMANCDK1_HUMANHPRD16247472 details
ECT2_HUMANBLM_HUMANBioGRID32929379 details
ECT2_HUMANCDC42_HUMANBioGRID32929379 details
ECT2_HUMANRAC1_HUMANBioGRID32929379 details
ECT2_HUMANRHOG_HUMANHPRD12376551 details
ECT2_HUMANKPCZ_HUMANBioGRID15254234 details