Entity Details

Primary name CFLAR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15519
EntryNameCFLAR_HUMAN
FullNameCASP8 and FADD-like apoptosis regulator
TaxID9606
Evidenceevidence at protein level
Length480
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesCFLAR

GO terms

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GOName
GO:0002020 protease binding
GO:0005123 death receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007519 skeletal muscle tissue development
GO:0008047 enzyme activator activity
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010976 positive regulation of neuron projection development
GO:0014732 skeletal muscle atrophy
GO:0014842 regulation of skeletal muscle satellite cell proliferation
GO:0014866 skeletal myofibril assembly
GO:0016032 viral process
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0032869 cellular response to insulin stimulus
GO:0033574 response to testosterone
GO:0042060 wound healing
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043403 skeletal muscle tissue regeneration
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060544 regulation of necroptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071549 cellular response to dexamethasone stimulus
GO:0071732 cellular response to nitric oxide
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0097342 ripoptosome
GO:1901740 negative regulation of myoblast fusion
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903055 positive regulation of extracellular matrix organization
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus
GO:1903944 negative regulation of hepatocyte apoptotic process
GO:2000347 positive regulation of hepatocyte proliferation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001875 Death effector domainDomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

76 interactions

InteractorPartnerSourcesPublicationsLink
CFLAR_HUMANCASP8_HUMANBioGRID, DIP, HPRD, IntAct, MINT11741985 12097160 12215447 12887920 15280356 17047155 17159907 19343040 19416807 19710364 21737329 21737330 22322857 22864571 24438025 26186194 28514442 31046799 9208847 9228018 9289491 9326610 9380701 details
CFLAR_HUMANCASPA_HUMANBioGRID, HPRD, IntAct12887920 21737330 23541952 25241761 9208847 9228018 9289491 details
CFLAR_HUMANSMAD3_HUMANBioGRID, IntAct21988832 details
CFLAR_HUMANRAF1_HUMANBioGRID, HPRD, IntAct10837247 16537561 21988832 details
CFLAR_HUMANSPAS1_HUMANBioGRID, IntAct21988832 details
CFLAR_HUMANFADD_HUMANBioGRID, HPRD, IntAct17047155 20829884 21737330 22322857 26972597 27321185 29497034 9208847 9228018 9326610 details
CFLAR_HUMANTRAF1_HUMANBioGRID, HPRD, IntAct10837247 25416956 32296183 9208847 details
CFLAR_HUMANCASP3_HUMANBioGRID, HPRD9208847 9326610 details
CFLAR_HUMANCFLAR_HUMANBioGRID29374180 9228018 details
CFLAR_HUMANDEDD2_HUMANBioGRID, HPRD11741985 11965497 details
CFLAR_HUMANDEDD_HUMANBioGRID, HPRD11741985 11965497 details
CFLAR_HUMANUBP8_HUMANBioGRID27321185 31443721 details
CFLAR_HUMANCUL1_HUMANBioGRID32313199 details
CFLAR_HUMANSKP2_HUMANBioGRID32313199 details
CFLAR_HUMANSKP1_HUMANBioGRID32313199 details
CFLAR_HUMANRBX1_HUMANBioGRID32313199 details
CFLAR_HUMANNFKB1_HUMANHPRD13679070 details
CFLAR_HUMANUBP15_HUMANIntAct17353931 details
CFLAR_HUMANEPIPL_HUMANIntAct17353931 details
CFLAR_HUMANFSCN1_HUMANIntAct17353931 details
CFLAR_HUMANRS29_HUMANIntAct17353931 details
CFLAR_HUMANFBRL_HUMANIntAct17353931 details
CFLAR_HUMANSF3B1_HUMANIntAct17353931 details
CFLAR_HUMANCDC37_HUMANIntAct17353931 details
CFLAR_HUMANMIF_HUMANIntAct17353931 details
CFLAR_HUMANSUN2_HUMANIntAct17353931 details
CFLAR_HUMANRADIL_HUMANIntAct17353931 details
CFLAR_HUMANHNRPL_HUMANIntAct17353931 details
CFLAR_HUMANEIF3F_HUMANIntAct17353931 details
CFLAR_HUMANEFTU_HUMANIntAct17353931 details
CFLAR_HUMANMP2K1_HUMANMINT17110930 details
CFLAR_HUMANMP2K4_HUMANHPRD, MINT17110930 details
CFLAR_HUMANMP2K7_HUMANHPRD, MINT17110930 details
CFLAR_HUMANTR10A_HUMANBioGRID, IntAct19343040 19427028 23142077 27321185 9325248 details
CFLAR_HUMANRIPK1_HUMANBioGRID, HPRD, IntAct10837247 11002417 17047155 21737330 26972597 details
CFLAR_HUMANTNF10_HUMANBioGRID, IntAct, MINT19432816 20097879 21459798 21525171 21822306 22266862 23678861 details
CFLAR_HUMANTNR6_HUMANBioGRID, IntAct21803845 27321185 9208847 9325248 details
CFLAR_HUMANCBLB_HUMANBioGRID, MINT22884570 details
CFLAR_HUMANNUDC3_HUMANIntAct25036637 details
CFLAR_HUMANPSMD2_HUMANIntAct25036637 details
CFLAR_HUMANFKBPL_HUMANIntAct25036637 details
CFLAR_HUMANCHIP_HUMANBioGRID, IntAct23256568 25036637 details
CFLAR_HUMANCYBP_HUMANIntAct25036637 details
CFLAR_HUMANPTG3L_HUMANIntAct25036637 details
CFLAR_HUMANAASD1_HUMANIntAct25036637 details
CFLAR_HUMANRIPK2_HUMANBioGRID, HPRD9575181 details
CFLAR_HUMANTRAF2_HUMANBioGRID, HPRD10837247 32313199 9208847 details
CFLAR_HUMANTR10B_HUMANBioGRID, HPRD11193041 11940602 19343040 23142077 32313199 9325248 details
CFLAR_HUMANNOD1_HUMANBioGRID10329646 details
CFLAR_HUMANTRAF3_HUMANBioGRID10837247 details
CFLAR_HUMANB2CL1_HUMANBioGRID, HPRD9326610 details
CFLAR_HUMANM3K14_HUMANBioGRID11002417 details
CFLAR_HUMANP53_HUMANBioGRID18559494 21474069 details
CFLAR_HUMANITCH_HUMANBioGRID18559494 19090833 19808964 21474069 30736843 31443721 details
CFLAR_HUMANXRCC6_HUMANBioGRID22322857 details
CFLAR_HUMANATG3_HUMANBioGRID19838173 details
CFLAR_HUMANDAXX_HUMANBioGRID14637155 details
CFLAR_HUMANTNFL6_HUMANBioGRID21803845 details
CFLAR_HUMANHS90A_HUMANBioGRID23256568 details
CFLAR_HUMANGELS_HUMANBioGRID25246592 details
CFLAR_HUMANTCAM1_HUMANBioGRID21737330 details
CFLAR_HUMANDTX1_HUMANBioGRID29374180 details
CFLAR_HUMANLAMP1_HUMANBioGRID29374180 details
CFLAR_HUMANM3K5_HUMANBioGRID29227477 details
CFLAR_HUMANRNF31_HUMANBioGRID30361438 details
CFLAR_HUMANANM5_HUMANBioGRID30736843 details
CFLAR_HUMANANM1_HUMANBioGRID30736843 details
CFLAR_HUMANGMEB1_HUMANBioGRID31046799 details
CFLAR_HUMANUBP40_HUMANBioGRID31046799 details
CFLAR_HUMANERBB3_HUMANBioGRID31443721 details
CFLAR_HUMANSTALP_HUMANBioGRID31817770 details
CFLAR_HUMANPSN2_HUMANHPRD10069390 9219695 9990034 details
CFLAR_HUMANIKKB_HUMANHPRD11002417 details
CFLAR_HUMANCASP2_HUMANHPRD9228018 details
CFLAR_HUMANCASP6_HUMANHPRD9228018 details
CFLAR_HUMANCASP7_HUMANHPRD9228018 details