Entity Details

Primary name CP27B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15528
EntryNameCP27B_HUMAN
FullName25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length508
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesCYP27B1

GO terms

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GOName
GO:0004498 calcidiol 1-monooxygenase activity
GO:0005506 iron ion binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0006766 vitamin metabolic process
GO:0006816 calcium ion transport
GO:0008285 negative regulation of cell population proliferation
GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
GO:0010980 positive regulation of vitamin D 24-hydroxylase activity
GO:0020037 heme binding
GO:0030282 bone mineralization
GO:0030308 negative regulation of cell growth
GO:0030500 regulation of bone mineralization
GO:0032496 response to lipopolysaccharide
GO:0033280 response to vitamin D
GO:0034341 response to interferon-gamma
GO:0036378 calcitriol biosynthetic process from calciol
GO:0042359 vitamin D metabolic process
GO:0042369 vitamin D catabolic process
GO:0043627 response to estrogen
GO:0045618 positive regulation of keratinocyte differentiation
GO:0046697 decidualization
GO:0055074 calcium ion homeostasis
GO:0062185 secalciferol 1-monooxygenase activity
GO:0070314 G1 to G0 transition
GO:0070564 positive regulation of vitamin D receptor signaling pathway

Subcellular Location

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Subcellular Location
Mitochondrion membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00146 CalcifediolDrugbanksmall molecule
DB00153 ErgocalciferolDrugbanksmall molecule
DB01285 CorticotropinDrugbankbiotech
DB01436 AlfacalcidolDrugbanksmall molecule
DB11094 Vitamin DDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink