Entity Details

Primary name SMUF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HCE7
EntryNameSMUF1_HUMAN
FullNameE3 ubiquitin-protein ligase SMURF1
TaxID9606
Evidenceevidence at protein level
Length757
SequenceStatuscomplete
DateCreated2001-12-13
DateModified2021-06-02

Ontological Relatives

GenesSMURF1

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005543 phospholipid binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006611 protein export from nucleus
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007398 ectoderm development
GO:0016567 protein ubiquitination
GO:0030154 cell differentiation
GO:0030424 axon
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0032801 receptor catabolic process
GO:0034394 protein localization to cell surface
GO:0043025 neuronal cell body
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0048185 activin binding
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061630 ubiquitin protein ligase activity
GO:0061736 engulfment of target by autophagosome
GO:0061753 substrate localization to autophagosome
GO:0070062 extracellular exosome
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0071211 protein targeting to vacuole involved in autophagy
GO:0072659 protein localization to plasma membrane
GO:1903861 positive regulation of dendrite extension
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

252 interactions

InteractorPartnerSourcesPublicationsLink
SMUF1_HUMANRHOA_HUMANBioGRID, HPRD, MINT15710384 16472676 16622418 21708152 26825171 28169289 28294307 28658604 31623230 details
SMUF1_HUMANRNF11_HUMANBioGRID, IntAct, MINT15231748 28292929 32814053 details
SMUF1_HUMANSMAD2_HUMANBioGRID, MINT15221015 15231748 20207742 details
SMUF1_HUMANSMAD3_HUMANBioGRID, HPRD, MINT15221015 15231748 15761153 28839186 details
SMUF1_HUMANSMAD5_HUMANBioGRID, MINT11278251 12857866 15221015 15231748 16516194 17676934 18641638 19914168 20484049 22670624 details
SMUF1_HUMANSMAD1_HUMANBioGRID, HPRD, IntAct, MINT14701756 15221015 15231748 15761153 16611643 17289590 17510966 17676934 19914168 19917253 21685363 21708152 22152476 22670624 24828823 28881580 details
SMUF1_HUMANING2_HUMANBioGRID, HPRD, MINT15761153 20621832 details
SMUF1_HUMANPSME3_HUMANBioGRID, MINT20580715 details
SMUF1_HUMANPKHO1_HUMANBioGRID, HPRD, IntAct, MINT15761153 18641638 20484049 20580715 21382345 22152476 23032291 details
SMUF1_HUMANFXL15_HUMANBioGRID, MINT21572392 details
SMUF1_HUMANUB2V1_HUMANBioGRID, IntAct20804422 25260751 details
SMUF1_HUMANTRIB2_HUMANBioGRID, MINT24089522 25311538 details
SMUF1_HUMANRHOB_HUMANBioGRID, IntAct25249323 30587574 details
SMUF1_HUMANCHK1_HUMANIntAct25249323 details
SMUF1_HUMANKLF2_HUMANBioGRID, IntAct21382345 details
SMUF1_HUMANTRAF4_HUMANBioGRID, IntAct19937093 23973329 details
SMUF1_HUMANSPART_HUMANBioGRID, IntAct19307600 20804422 28514442 details
SMUF1_HUMANSMAD7_HUMANBioGRID, DIP, HPRD11278251 12151385 12519765 14722617 15221015 16720724 20937913 22152476 22773947 22921829 23959799 24700460 27292644 details
SMUF1_HUMANDCTN1_HUMANBioGRID, IntAct23184937 32814053 details
SMUF1_HUMANGRN_HUMANIntAct32814053 details
SMUF1_HUMANPRKN_HUMANIntAct32814053 details
SMUF1_HUMANWFS1_HUMANBioGRID, IntAct21454619 32814053 details
SMUF1_HUMANSPRE1_HUMANIntAct32814053 details
SMUF1_HUMANSYUA_HUMANIntAct32814053 details
SMUF1_HUMANHD_HUMANIntAct32814053 details
SMUF1_HUMANTADBP_HUMANIntAct32814053 details
SMUF1_HUMANARHG9_HUMANBioGRID, HPRD18208356 details
SMUF1_HUMANPDLI7_HUMANBioGRID16611643 17510966 details
SMUF1_HUMANSMAD6_HUMANBioGRID, HPRD11278251 15221015 17676934 21897371 28847510 29950561 details
SMUF1_HUMANJUNB_HUMANBioGRID20200942 details
SMUF1_HUMANESR1_HUMANBioGRID20207742 29433542 details
SMUF1_HUMANACK1_HUMANBioGRID19144635 details
SMUF1_HUMANTLN1_HUMANBioGRID19363486 details
SMUF1_HUMANMDM2_HUMANBioGRID20484049 details
SMUF1_HUMANTRIB3_HUMANBioGRID17576816 details
SMUF1_HUMANCCM2_HUMANBioGRID19318350 31623230 details
SMUF1_HUMANSMUF1_HUMANBioGRID17996703 18641638 19318350 22152476 22496338 22921829 24821572 26949039 28063214 28169289 30587574 31628949 details
SMUF1_HUMANM3K3_HUMANBioGRID19318350 details
SMUF1_HUMANM3K2_HUMANBioGRID, HPRD15820682 19318350 20804422 details
SMUF1_HUMANUB2D3_HUMANBioGRID18641638 20484049 20621832 20804422 23959799 24089522 24821572 24828823 25723849 28169289 28881580 32010791 32737433 details
SMUF1_HUMANFZR1_HUMANBioGRID22152476 22949615 details
SMUF1_HUMANA4_HUMANBioGRID21832049 details
SMUF1_HUMANUSP9X_HUMANBioGRID23184937 details
SMUF1_HUMANUBC_HUMANBioGRID23184937 25723849 28881580 31628949 details
SMUF1_HUMANFBW1A_HUMANBioGRID21572392 28063214 details
SMUF1_HUMANAXIN1_HUMANBioGRID23959799 24700460 details
SMUF1_HUMANUB2L3_HUMANBioGRID17996703 20804422 24821572 24828823 25723849 26949039 28169289 28881580 29263404 30587574 31628949 details
SMUF1_HUMANUBC12_HUMANBioGRID24821572 28169289 details
SMUF1_HUMANSENP8_HUMANBioGRID24821572 details
SMUF1_HUMANRPB1_HUMANBioGRID17996703 details
SMUF1_HUMANLATS1_HUMANBioGRID24107629 details
SMUF1_HUMANCTNB1_HUMANBioGRID26015066 details
SMUF1_HUMANFBX3_HUMANBioGRID25721664 details
SMUF1_HUMANUB2D1_HUMANBioGRID20804422 25723849 details
SMUF1_HUMANUB2D2_HUMANBioGRID20804422 25723849 29643511 details
SMUF1_HUMANRASF1_HUMANBioGRID26825171 details
SMUF1_HUMANUBP5_HUMANBioGRID20804422 27133717 32683298 details
SMUF1_HUMANAN13D_HUMANBioGRID20804422 details
SMUF1_HUMANPSMD4_HUMANBioGRID20804422 details
SMUF1_HUMANTOM1_HUMANBioGRID20804422 details
SMUF1_HUMANHOIL1_HUMANBioGRID20804422 details
SMUF1_HUMANCUED1_HUMANBioGRID20804422 details
SMUF1_HUMANUBAC1_HUMANBioGRID20804422 details
SMUF1_HUMANMINY3_HUMANBioGRID20804422 details
SMUF1_HUMANUB2G1_HUMANBioGRID20804422 details
SMUF1_HUMANUBQL2_HUMANBioGRID20804422 details
SMUF1_HUMANTNIP2_HUMANBioGRID20804422 details
SMUF1_HUMANTM1L2_HUMANBioGRID20804422 details
SMUF1_HUMANRABE1_HUMANBioGRID20804422 details
SMUF1_HUMANRD23A_HUMANBioGRID20804422 details
SMUF1_HUMANATX3_HUMANBioGRID20804422 details
SMUF1_HUMANTAOK3_HUMANBioGRID20804422 details
SMUF1_HUMANEPHA1_HUMANBioGRID20804422 details
SMUF1_HUMANEPN1_HUMANBioGRID20804422 details
SMUF1_HUMANILRUN_HUMANBioGRID20804422 details
SMUF1_HUMANKPCA_HUMANBioGRID20804422 details
SMUF1_HUMANODFP2_HUMANBioGRID20804422 details
SMUF1_HUMANANS4B_HUMANBioGRID20804422 details
SMUF1_HUMANUBXN6_HUMANBioGRID20804422 details
SMUF1_HUMANNEK2_HUMANBioGRID20804422 details
SMUF1_HUMANUBE2K_HUMANBioGRID20804422 details
SMUF1_HUMANUBQL1_HUMANBioGRID20804422 details
SMUF1_HUMANHIP1_HUMANBioGRID20804422 details
SMUF1_HUMANUBXN7_HUMANBioGRID20804422 details
SMUF1_HUMANENTR1_HUMANBioGRID20804422 details
SMUF1_HUMANANR50_HUMANBioGRID20804422 details
SMUF1_HUMANHOME2_HUMANBioGRID20804422 details
SMUF1_HUMANKPCI_HUMANBioGRID20804422 details
SMUF1_HUMANZFAN5_HUMANBioGRID20804422 details
SMUF1_HUMANTPM4_HUMANBioGRID20804422 details
SMUF1_HUMANKRT36_HUMANBioGRID20804422 details
SMUF1_HUMANFKBP3_HUMANBioGRID20804422 details
SMUF1_HUMANFAF2_HUMANBioGRID20804422 details
SMUF1_HUMANFES_HUMANBioGRID20804422 details
SMUF1_HUMANSRC8_HUMANBioGRID20804422 details
SMUF1_HUMANMATK_HUMANBioGRID20804422 details
SMUF1_HUMANELOF1_HUMANBioGRID20804422 details
SMUF1_HUMANRIOK3_HUMANBioGRID20804422 details
SMUF1_HUMANCIP4_HUMANBioGRID20804422 details
SMUF1_HUMANCACO1_HUMANBioGRID20804422 details
SMUF1_HUMANSCYL1_HUMANBioGRID20804422 details
SMUF1_HUMANADRM1_HUMANBioGRID20804422 details
SMUF1_HUMANRN114_HUMANBioGRID20804422 details
SMUF1_HUMANM3K9_HUMANBioGRID20804422 details
SMUF1_HUMANIMPCT_HUMANBioGRID20804422 details
SMUF1_HUMANPICAL_HUMANBioGRID20804422 details
SMUF1_HUMANPGFRA_HUMANBioGRID20804422 details
SMUF1_HUMANANXA6_HUMANBioGRID20804422 details
SMUF1_HUMANLMNA_HUMANBioGRID20804422 details
SMUF1_HUMANPADI4_HUMANBioGRID20804422 details
SMUF1_HUMANTNIK_HUMANBioGRID20804422 details
SMUF1_HUMANSLAI2_HUMANBioGRID20804422 details
SMUF1_HUMANOTU6B_HUMANBioGRID20804422 details
SMUF1_HUMANCSK22_HUMANBioGRID, HPRD15761153 20804422 details
SMUF1_HUMANLARGN_HUMANBioGRID20804422 details
SMUF1_HUMANKC1D_HUMANBioGRID20804422 details
SMUF1_HUMANBTK_HUMANBioGRID20804422 details
SMUF1_HUMANASCC2_HUMANBioGRID20804422 details
SMUF1_HUMANFGF12_HUMANBioGRID20804422 details
SMUF1_HUMANMARK2_HUMANBioGRID20804422 details
SMUF1_HUMANFGR_HUMANBioGRID20804422 details
SMUF1_HUMANM3K10_HUMANBioGRID20804422 details
SMUF1_HUMANKPCG_HUMANBioGRID20804422 details
SMUF1_HUMANTLS1_HUMANBioGRID20804422 details
SMUF1_HUMANCCD69_HUMANBioGRID20804422 details
SMUF1_HUMANMOES_HUMANBioGRID20804422 details
SMUF1_HUMANTAB1_HUMANBioGRID20804422 details
SMUF1_HUMANLCK_HUMANBioGRID20804422 details
SMUF1_HUMANARBK2_HUMANBioGRID20804422 details
SMUF1_HUMANM4K5_HUMANBioGRID20804422 details
SMUF1_HUMANSTK31_HUMANBioGRID20804422 details
SMUF1_HUMANAN13A_HUMANBioGRID20804422 details
SMUF1_HUMANITK_HUMANBioGRID20804422 details
SMUF1_HUMANDDX54_HUMANBioGRID20804422 details
SMUF1_HUMANTBK1_HUMANBioGRID20804422 details
SMUF1_HUMANNEDD8_HUMANBioGRID28169289 details
SMUF1_HUMANFSCN1_HUMANBioGRID27879315 details
SMUF1_HUMANITBP1_HUMANBioGRID28049720 details
SMUF1_HUMANWEE1_HUMANBioGRID, HPRD15761153 28294307 details
SMUF1_HUMANFERM2_HUMANBioGRID28408404 31578224 details
SMUF1_HUMANPI51C_HUMANBioGRID28581524 details
SMUF1_HUMANBMPR2_HUMANBioGRID31578224 details
SMUF1_HUMANLIMS1_HUMANBioGRID, HPRD15761153 31578224 details
SMUF1_HUMANCTND1_HUMANBioGRID32010791 details
SMUF1_HUMANSRBP1_HUMANBioGRID32301540 details
SMUF1_HUMANPTEN_HUMANBioGRID32737433 details
SMUF1_HUMANRUNX2_HUMANBioGRID, IntAct16299379 17215250 details
SMUF1_HUMANDVL2_HUMANHPRD, IntAct19379695 details
SMUF1_HUMANING1_HUMANBioGRID, MINT20621832 details
SMUF1_HUMANPRS8_HUMANBioGRID, MINT23032291 details
SMUF1_HUMANGBG11_HUMANBioGRID, HPRD, IntAct15761153 25241761 details
SMUF1_HUMANECSIT_HUMANBioGRID, HPRD, IntAct15761153 25241761 details
SMUF1_HUMANSMUF2_HUMANBioGRID, IntAct18927080 21897371 27086113 28514442 details
SMUF1_HUMANTGFR1_HUMANBioGRID11278251 12857866 14657019 details
SMUF1_HUMANACV1B_HUMANBioGRID12857866 16720724 details
SMUF1_HUMANSMAD4_HUMANBioGRID15817471 23973329 details
SMUF1_HUMANRUNX3_HUMANBioGRID, HPRD15138260 details
SMUF1_HUMANTGFR2_HUMANBioGRID11278251 27048878 details
SMUF1_HUMANP53_HUMANBioGRID20484049 details
SMUF1_HUMANNFIC_HUMANBioGRID22195013 details
SMUF1_HUMANPAR6A_HUMANBioGRID15761148 21262463 details
SMUF1_HUMANACVR1_HUMANBioGRID12857866 31685442 details
SMUF1_HUMANBMR1A_HUMANBioGRID12857866 details
SMUF1_HUMANBMR1B_HUMANBioGRID12857866 details
SMUF1_HUMANSTAT1_HUMANBioGRID22474288 details
SMUF1_HUMANXPO1_HUMANBioGRID, HPRD12519765 details
SMUF1_HUMANMYD88_HUMANBioGRID21897371 details
SMUF1_HUMANNFIP1_HUMANBioGRID23087404 details
SMUF1_HUMANMAVS_HUMANBioGRID23087404 details
SMUF1_HUMANRHG32_HUMANBioGRID23226367 details
SMUF1_HUMANSTK38_HUMANBioGRID23184937 29549164 details
SMUF1_HUMANST38L_HUMANBioGRID23184937 30504095 details
SMUF1_HUMANSF3A1_HUMANBioGRID, HPRD15761153 23184937 details
SMUF1_HUMANTERA_HUMANBioGRID23184937 30335548 details
SMUF1_HUMAN1433T_HUMANBioGRID23444366 details
SMUF1_HUMANEFNB1_HUMANBioGRID23475958 details
SMUF1_HUMANFBX42_HUMANBioGRID21572392 details
SMUF1_HUMANFBX21_HUMANBioGRID21572392 details
SMUF1_HUMANFBXL5_HUMANBioGRID21572392 details
SMUF1_HUMANPTC1_HUMANBioGRID25092867 details
SMUF1_HUMANNR2E1_HUMANBioGRID27048878 details
SMUF1_HUMANVHL_HUMANBioGRID27517496 32328410 details
SMUF1_HUMANSETD7_HUMANBioGRID27292644 details
SMUF1_HUMANPCBP1_HUMANBioGRID28963376 details
SMUF1_HUMANIQGA1_HUMANBioGRID28469997 details
SMUF1_HUMANPKHD1_HUMANBioGRID28798345 details
SMUF1_HUMANPTTG1_HUMANBioGRID28658604 details
SMUF1_HUMANPI51A_HUMANBioGRID28581524 details
SMUF1_HUMANPI51B_HUMANBioGRID28581524 details
SMUF1_HUMANFMN2_HUMANBioGRID29659741 details
SMUF1_HUMANOTUD1_HUMANBioGRID29734366 details
SMUF1_HUMANNPL4_HUMANBioGRID30335548 details
SMUF1_HUMANRHG26_HUMANBioGRID31004081 details
SMUF1_HUMANUVRAG_HUMANBioGRID30686098 details
SMUF1_HUMANPLIN2_HUMANBioGRID31701069 details
SMUF1_HUMANSIR1_HUMANBioGRID32361710 details
SMUF1_HUMANNFIP2_HUMANHPRD15252135 details
SMUF1_HUMANAPC5_HUMANHPRD15761153 details
SMUF1_HUMANAP2B1_HUMANHPRD15761153 details
SMUF1_HUMANAPBB2_HUMANHPRD15761153 details
SMUF1_HUMANARL4D_HUMANHPRD15761153 details
SMUF1_HUMANARL14_HUMANHPRD15761153 details
SMUF1_HUMANRHG15_HUMANHPRD15761153 details
SMUF1_HUMANASH2L_HUMANHPRD15761153 details
SMUF1_HUMANAVEN_HUMANHPRD15761153 details
SMUF1_HUMANPRP17_HUMANHPRD15761153 details
SMUF1_HUMANCDKL1_HUMANHPRD15761153 details
SMUF1_HUMANCUL5_HUMANHPRD15761153 details
SMUF1_HUMANCXXC1_HUMANHPRD15761153 details
SMUF1_HUMANDNJC7_HUMANHPRD15761153 details
SMUF1_HUMANDS13A_HUMANHPRD15761153 details
SMUF1_HUMANELP3_HUMANHPRD15761153 details
SMUF1_HUMANETV6_HUMANHPRD15761153 details
SMUF1_HUMANFBX30_HUMANHPRD15761153 details
SMUF1_HUMANFCHO1_HUMANHPRD15761153 details
SMUF1_HUMANGRAP1_HUMANHPRD15761153 details
SMUF1_HUMANHDGR3_HUMANHPRD15761153 details
SMUF1_HUMANI5P2_HUMANHPRD15761153 details
SMUF1_HUMANIRAK2_HUMANHPRD15761153 details
SMUF1_HUMANLHX9_HUMANHPRD15761153 details
SMUF1_HUMANLONF3_HUMANHPRD15761153 details
SMUF1_HUMANNAA16_HUMANHPRD15761153 details
SMUF1_HUMANOCLN_HUMANHPRD15761153 details
SMUF1_HUMANOXSR1_HUMANHPRD15761153 details
SMUF1_HUMANPK1IP_HUMANHPRD15761153 details
SMUF1_HUMANPAK1_HUMANHPRD15761153 details
SMUF1_HUMANCDK14_HUMANHPRD15761153 details
SMUF1_HUMANPWP1_HUMANHPRD15761153 details
SMUF1_HUMANRHES_HUMANHPRD15761153 details
SMUF1_HUMANRHPN2_HUMANHPRD15761153 details
SMUF1_HUMANRIPK2_HUMANHPRD15761153 details
SMUF1_HUMANRIT1_HUMANHPRD15761153 details
SMUF1_HUMANRN141_HUMANHPRD15761153 details
SMUF1_HUMANRS27A_HUMANHPRD15761153 details
SMUF1_HUMANRTKN_HUMANHPRD15761153 details
SMUF1_HUMANSRSF4_HUMANHPRD15761153 details
SMUF1_HUMANSRSF5_HUMANHPRD15761153 details
SMUF1_HUMANSQSTM_HUMANHPRD15761153 details
SMUF1_HUMANSTK35_HUMANHPRD15761153 details
SMUF1_HUMANCHIP_HUMANHPRD15761153 details
SMUF1_HUMANTNNT1_HUMANHPRD15761153 details
SMUF1_HUMANTTC17_HUMANHPRD15761153 details
SMUF1_HUMANRL40_HUMANHPRD15761153 details
SMUF1_HUMANUBB_HUMANHPRD15761153 details
SMUF1_HUMANUBF1_HUMANHPRD15761153 details
SMUF1_HUMANUBP45_HUMANHPRD15761153 details
SMUF1_HUMANWDR61_HUMANHPRD15761153 details
SMUF1_HUMANU3IP2_HUMANHPRD15761153 details
SMUF1_HUMANUBXN1_HUMANHPRD15761153 details
SMUF1_HUMANSTRAP_HUMANHPRD15761153 details
SMUF1_HUMANRHG31_HUMANHPRD15761153 details
SMUF1_HUMANSASH3_HUMANHPRD15761153 details