Entity Details

Primary name NOX4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NPH5
EntryNameNOX4_HUMAN
FullNameNADPH oxidase 4
TaxID9606
Evidenceevidence at protein level
Length578
SequenceStatuscomplete
DateCreated2006-05-30
DateModified2021-06-02

Ontological Relatives

GenesNOX4

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0000902 cell morphogenesis
GO:0001666 response to hypoxia
GO:0001725 stress fiber
GO:0003015 heart process
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006801 superoxide metabolic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007569 cell aging
GO:0008285 negative regulation of cell population proliferation
GO:0009055 electron transfer activity
GO:0010467 gene expression
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016021 integral component of membrane
GO:0016174 NAD(P)H oxidase H2O2-forming activity
GO:0016175 superoxide-generating NAD(P)H oxidase activity
GO:0016324 apical plasma membrane
GO:0019826 oxygen sensor activity
GO:0020037 heme binding
GO:0034599 cellular response to oxidative stress
GO:0042554 superoxide anion generation
GO:0043020 NADPH oxidase complex
GO:0043065 positive regulation of apoptotic process
GO:0048471 perinuclear region of cytoplasm
GO:0050660 flavin adenine dinucleotide binding
GO:0050667 homocysteine metabolic process
GO:0051496 positive regulation of stress fiber assembly
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0071320 cellular response to cAMP
GO:0071480 cellular response to gamma radiation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072341 modified amino acid binding
GO:0072593 reactive oxygen species metabolic process
GO:0097038 perinuclear endoplasmic reticulum
GO:1903409 reactive oxygen species biosynthetic process
GO:1990782 protein tyrosine kinase binding
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000778 Cytochrome b245, heavy chainFamilyFamily
IPR013112 FAD-binding 8DomainDomain
IPR013121 Ferric reductase, NAD binding domainDomainDomain
IPR013130 Ferric reductase transmembrane component-like domainDomainDomain
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Interactions

4 interactions