Entity Details

Primary name SPHK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NRA0
EntryNameSPHK2_HUMAN
FullNameSphingosine kinase 2
TaxID9606
Evidenceevidence at protein level
Length654
SequenceStatuscomplete
DateCreated2001-10-24
DateModified2021-06-02

Ontological Relatives

GenesSPHK2

GO terms

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GOName
GO:0000786 nucleosome
GO:0001727 lipid kinase activity
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0003951 NAD+ kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006665 sphingolipid metabolic process
GO:0006669 sphinganine-1-phosphate biosynthetic process
GO:0006670 sphingosine metabolic process
GO:0008481 sphinganine kinase activity
GO:0016020 membrane
GO:0016310 phosphorylation
GO:0017050 D-erythro-sphingosine kinase activity
GO:0030148 sphingolipid biosynthetic process
GO:0030308 negative regulation of cell growth
GO:0031064 negative regulation of histone deacetylation
GO:0031267 small GTPase binding
GO:0031493 nucleosomal histone binding
GO:0032736 positive regulation of interleukin-13 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033008 positive regulation of mast cell activation involved in immune response
GO:0038036 sphingosine-1-phosphate receptor activity
GO:0043065 positive regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0043306 positive regulation of mast cell degranulation
GO:0043977 histone H2A-K5 acetylation
GO:0043980 histone H2B-K12 acetylation
GO:0045815 positive regulation of gene expression, epigenetic
GO:0046512 sphingosine biosynthetic process
GO:0090037 positive regulation of protein kinase C signaling
GO:0090280 positive regulation of calcium ion import
GO:1901726 negative regulation of histone deacetylase activity
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1904628 cellular response to phorbol 13-acetate 12-myristate
GO:1904959 regulation of cytochrome-c oxidase activity
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:2001169 regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Lysosome membrane
Mitochondrion inner membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001206 Diacylglycerol kinase, catalytic domainDomainDomain
IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamilyFamilyHomologous superfamily
IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12764 OpaganibDrugbanksmall molecule