Entity Details

Primary name PRGC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBK2
EntryNamePRGC1_HUMAN
FullNamePeroxisome proliferator-activated receptor gamma coactivator 1-alpha
TaxID9606
Evidenceevidence at protein level
Length798
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesPPARGC1A

GO terms

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GOName
GO:0000302 response to reactive oxygen species
GO:0000422 autophagy of mitochondrion
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0001659 temperature homeostasis
GO:0001678 cellular glucose homeostasis
GO:0001933 negative regulation of protein phosphorylation
GO:0002021 response to dietary excess
GO:0002931 response to ischemia
GO:0003677 DNA binding
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006012 galactose metabolic process
GO:0006094 gluconeogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0007005 mitochondrion organization
GO:0007568 aging
GO:0007586 digestion
GO:0007623 circadian rhythm
GO:0008134 transcription factor binding
GO:0008209 androgen metabolic process
GO:0008380 RNA splicing
GO:0009409 response to cold
GO:0010628 positive regulation of gene expression
GO:0010822 positive regulation of mitochondrion organization
GO:0014732 skeletal muscle atrophy
GO:0014850 response to muscle activity
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016605 PML body
GO:0016922 nuclear receptor binding
GO:0019395 fatty acid oxidation
GO:0021549 cerebellum development
GO:0022626 cytosolic ribosome
GO:0022904 respiratory electron transport chain
GO:0030331 estrogen receptor binding
GO:0030374 nuclear receptor coactivator activity
GO:0030900 forebrain development
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0032922 circadian regulation of gene expression
GO:0034599 cellular response to oxidative stress
GO:0035066 positive regulation of histone acetylation
GO:0035865 cellular response to potassium ion
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0042752 regulation of circadian rhythm
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043014 alpha-tubulin binding
GO:0043025 neuronal cell body
GO:0043201 response to leucine
GO:0043231 intracellular membrane-bounded organelle
GO:0043524 negative regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045333 cellular respiration
GO:0045722 positive regulation of gluconeogenesis
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046321 positive regulation of fatty acid oxidation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050821 protein stabilization
GO:0050873 brown fat cell differentiation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051552 flavone metabolic process
GO:0060612 adipose tissue development
GO:0065003 protein-containing complex assembly
GO:0071222 cellular response to lipopolysaccharide
GO:0071250 cellular response to nitrite
GO:0071313 cellular response to caffeine
GO:0071332 cellular response to fructose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071871 response to epinephrine
GO:0071873 response to norepinephrine
GO:0090258 negative regulation of mitochondrial fission
GO:0097009 energy homeostasis
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097440 apical dendrite
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901215 negative regulation of neuron death
GO:1901558 response to metformin
GO:1901857 positive regulation of cellular respiration
GO:1901860 positive regulation of mitochondrial DNA metabolic process
GO:1901863 positive regulation of muscle tissue development
GO:1904635 positive regulation of glomerular visceral epithelial cell apoptotic process
GO:1904637 cellular response to ionomycin
GO:1904639 cellular response to resveratrol
GO:1904640 response to methionine
GO:1990841 promoter-specific chromatin binding
GO:1990845 adaptive thermogenesis
GO:2000184 positive regulation of progesterone biosynthetic process
GO:2000272 negative regulation of signaling receptor activity
GO:2000310 regulation of NMDA receptor activity
GO:2001171 positive regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR034605 PGC-1FamilyFamily
IPR034625 Peroxisome proliferator-activated receptor gamma coactivator 1-alphaFamilyFamily
IPR034833 PGC-1alpha, RNA recognition motifDomainDomain
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
PRGC1_HUMANLPPRC_HUMANBioGRID, UniProt17050673 details
PRGC1_HUMANERR3_HUMANBioGRID, HPRD, IntAct, MINT12181319 12470660 15821111 18063693 19171140 19914244 32296183 details
PRGC1_HUMANPPARG_HUMANBioGRID, HPRD, IntAct, MINT10558993 12502716 12522104 14636573 15026545 17011503 17468099 17513608 17704298 17785586 18469005 18674809 19596656 19631645 19846556 22070604 23178929 30595551 30651555 details
PRGC1_HUMANCPNS1_HUMANBioGRID, IntAct21988832 details
PRGC1_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
PRGC1_HUMANRORG_HUMANIntAct20203100 details
PRGC1_HUMANHNF4A_HUMANBioGRID, HPRD, IntAct15322103 15331348 15744310 15826954 17636037 18552123 19846556 20926756 22009745 22155889 details
PRGC1_HUMANRARB_HUMANBioGRID, IntAct32296183 details
PRGC1_HUMANERR1_HUMANBioGRID, HPRD, IntAct12181319 12522104 15337744 18063693 18441008 32296183 details
PRGC1_HUMANPPARA_HUMANBioGRID, IntAct10669761 21775429 details
PRGC1_HUMANPPARD_HUMANBioGRID, IntAct19596656 21775429 details
PRGC1_HUMANNR5A2_HUMANBioGRID, DIP17283069 20133449 22504882 details
PRGC1_HUMANESR1_HUMANBioGRID, HPRD, IntAct10748020 12522104 18441008 details
PRGC1_HUMANRXRA_HUMANBioGRID, HPRD, IntAct11714715 12522104 details
PRGC1_HUMANNR1H4_HUMANBioGRID, HPRD14729567 details
PRGC1_HUMANMED1_HUMANBioGRID, HPRD14636573 details
PRGC1_HUMANMED17_HUMANBioGRID14636573 details
PRGC1_HUMANMED12_HUMANBioGRID14636573 details
PRGC1_HUMANMED14_HUMANBioGRID14636573 details
PRGC1_HUMANTHB_HUMANBioGRID, HPRD11751919 details
PRGC1_HUMANNRF1_HUMANBioGRID, HPRD10412986 11943463 details
PRGC1_HUMANGCR_HUMANBioGRID, HPRD10713165 18160712 details
PRGC1_HUMANNCOA1_HUMANBioGRID, HPRD10558993 details
PRGC1_HUMANCBP_HUMANBioGRID10558993 details
PRGC1_HUMANFBXW7_HUMANBioGRID, HPRD18198341 details
PRGC1_HUMANGSK3B_HUMANBioGRID, HPRD18198341 details
PRGC1_HUMANSIR1_HUMANBioGRID, HPRD15716268 15744310 19553684 details
PRGC1_HUMANNCOA6_HUMANBioGRID18552123 details
PRGC1_HUMANNR1I2_HUMANBioGRID, HPRD15322103 15331348 15604093 16455805 details
PRGC1_HUMANESR2_HUMANBioGRID, HPRD15604093 15784253 details
PRGC1_HUMANP53_HUMANBioGRID22099309 details
PRGC1_HUMANUBC9_HUMANBioGRID19625249 details
PRGC1_HUMANCR3L3_HUMANBioGRID21994947 details
PRGC1_HUMANUSF2_HUMANBioGRID, HPRD12611894 details
PRGC1_HUMANUSF1_HUMANBioGRID12611894 details
PRGC1_HUMANNR1I3_HUMANBioGRID, HPRD15572376 26407237 details
PRGC1_HUMANSKP1_HUMANBioGRID26407237 details
PRGC1_HUMANNECD_HUMANBioGRID26971449 details
PRGC1_HUMANTF65_HUMANBioGRID, IntAct17785586 23174781 details
PRGC1_HUMANAAPK2_HUMANDIP17609368 details
PRGC1_HUMANMED16_HUMANBioGRID14636573 details
PRGC1_HUMANMED21_HUMANBioGRID14636573 details
PRGC1_HUMANMED20_HUMANBioGRID14636573 details
PRGC1_HUMANHCFC1_HUMANBioGRID, HPRD11733490 details
PRGC1_HUMANSRSF5_HUMANBioGRID, HPRD10983978 details
PRGC1_HUMANSRSF6_HUMANBioGRID, HPRD10983978 details
PRGC1_HUMANSRSF4_HUMANBioGRID, HPRD10983978 details
PRGC1_HUMANSRSF2_HUMANBioGRID10983978 details
PRGC1_HUMANEP300_HUMANBioGRID17050673 details
PRGC1_HUMANIQGA1_HUMANBioGRID17050673 details
PRGC1_HUMANMYOD1_HUMANBioGRID19553684 details
PRGC1_HUMANMYEF2_HUMANBioGRID15111488 details
PRGC1_HUMANSF01_HUMANBioGRID20133449 details
PRGC1_HUMANRNF34_HUMANBioGRID22064484 details
PRGC1_HUMANRING2_HUMANBioGRID22099309 details
PRGC1_HUMANPIAS1_HUMANBioGRID22969086 details
PRGC1_HUMANSFPQ_HUMANBioGRID18689799 details
PRGC1_HUMANEGFR_HUMANBioGRID23956138 details
PRGC1_HUMANAAPK1_HUMANBioGRID24371122 details
PRGC1_HUMANKAT2A_HUMANBioGRID24371122 details
PRGC1_HUMANNRIP1_HUMANBioGRID19625249 details
PRGC1_HUMANNFKB1_HUMANBioGRID17785586 details
PRGC1_HUMANEWS_HUMANBioGRID25918410 details
PRGC1_HUMANPML_HUMANBioGRID26407237 details
PRGC1_HUMANNR4A2_HUMANBioGRID21757690 details
PRGC1_HUMANTNAP3_HUMANBioGRID29678181 details
PRGC1_HUMANMK14_HUMANHPRD11741533 details
PRGC1_HUMANMBB1A_HUMANHPRD14744933 details
PRGC1_HUMANUBC_HUMANHPRD18198341 details
PRGC1_HUMANNUCL_HUMANHPRD10983978 details