Entity Details

Primary name CAC1G_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43497
EntryNameCAC1G_HUMAN
FullNameVoltage-dependent T-type calcium channel subunit alpha-1G
TaxID9606
Evidenceevidence at protein level
Length2377
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCACNA1G

GO terms

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GOName
GO:0001518 voltage-gated sodium channel complex
GO:0003163 sinoatrial node development
GO:0005248 voltage-gated sodium channel activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0007268 chemical synaptic transmission
GO:0008332 low voltage-gated calcium channel activity
GO:0010045 response to nickel cation
GO:0019228 neuronal action potential
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086010 membrane depolarization during action potential
GO:0086015 SA node cell action potential
GO:0086016 AV node cell action potential
GO:0086018 SA node cell to atrial cardiac muscle cell signaling
GO:0086027 AV node cell to bundle of His cell signaling
GO:0086045 membrane depolarization during AV node cell action potential
GO:0086046 membrane depolarization during SA node cell action potential
GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential
GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0097110 scaffold protein binding

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR002077 Voltage-dependent calcium channel, alpha-1 subunitFamilyFamily
IPR005445 Voltage-dependent calcium channel, T-type, alpha-1 subunitFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00153 ErgocalciferolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00347 TrimethadioneDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00593 EthosuximideDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00909 ZonisamideDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01388 MibefradilDrugbanksmall molecule
DB04841 FlunarizineDrugbanksmall molecule
DB05246 MethsuximideDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09231 BenidipineDrugbanksmall molecule
DB09238 ManidipineDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CAC1G_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16713569 details
CAC1G_HUMANRANB9_HUMANBioGRID18801335 details