Entity Details

Primary name HAOX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UJM8
EntryNameHAOX1_HUMAN
FullNameHydroxyacid oxidase 1
TaxID9606
Evidenceevidence at protein level
Length370
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesHAO1

GO terms

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GOName
GO:0001561 fatty acid alpha-oxidation
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0006979 response to oxidative stress
GO:0008104 protein localization
GO:0008891 glycolate oxidase activity
GO:0010181 FMN binding
GO:0019752 carboxylic acid metabolic process
GO:0046296 glycolate catabolic process
GO:0052852 very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853 long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854 medium-chain-(S)-2-hydroxy-acid oxidase activity

Subcellular Location

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Subcellular Location
Peroxisome

Domains

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DomainNameCategoryType
IPR000262 FMN-dependent dehydrogenaseDomainDomain
IPR008259 FMN-dependent alpha-hydroxy acid dehydrogenase, active siteSiteActive site
IPR012133 Alpha-hydroxy acid dehydrogenase, FMN-dependentFamilyFamily
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR037396 FMN hydroxy acid dehydrogenase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB02164 N-sulfo-flavin mononucleotideDrugbanksmall molecule
DB02279 Benzoylformic AcidDrugbanksmall molecule
DB03064 3-Decyl-2,5-Dioxo-4-Hydroxy-3-PyrrolineDrugbanksmall molecule
DB03247 Flavin mononucleotideDrugbanksmall molecule
DB03884 Phenylpyruvic acidDrugbanksmall molecule
DB04374 4-Carboxy-5-(1-Pentyl)Hexylsulfanyl-1,2,3-TriazoleDrugbanksmall molecule
DB06979 5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acidDrugbanksmall molecule
DB07060 3-(INDOL-3-YL) LACTATEDrugbanksmall molecule
DB07907 (2S)-2-HYDROXYOCTANOIC ACIDDrugbanksmall molecule
DB15935 LumasiranDrugbankbiotech

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HAOX1_HUMANPEX5_HUMANBioGRID20178365 details