Entity Details

Primary name ADA28_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UKQ2
EntryNameADA28_HUMAN
FullNameDisintegrin and metalloproteinase domain-containing protein 28
TaxID9606
Evidenceevidence at protein level
Length775
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesADAM28

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005576 extracellular region
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0007283 spermatogenesis
GO:0008237 metallopeptidase activity
GO:0016021 integral component of membrane
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR001762 Disintegrin domainDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR006586 ADAM, cysteine-rich domainDomainDomain
IPR018358 Disintegrin, conserved siteSiteConserved site
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR034027 Reprolysin domain, adamalysin-typeDomainDomain
IPR036436 Disintegrin domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02046 N-[(Furan-2-Yl)Carbonyl]-(S)-Leucyl-(R)-[1-Amino-2(1h-Indol-3-Yl)Ethyl]-Phosphonic AcidDrugbanksmall molecule
DB02215 Furoyl-LeucineDrugbanksmall molecule
DB02255 IlomastatDrugbanksmall molecule
DB02996 2-(Thiomethylene)-4-Methylpentanoic AcidDrugbanksmall molecule
DB03088 Pidolic acidDrugbanksmall molecule
DB03880 BatimastatDrugbanksmall molecule
DB08733 (2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDEDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ADA28_HUMANUROK_HUMANBioGRID, IntAct32296183 details
ADA28_HUMANITA4_HUMANHPRD11724793 details