Entity Details

Primary name NCK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43639
EntryNameNCK2_HUMAN
FullNameCytoplasmic protein NCK2
TaxID9606
Evidenceevidence at protein level
Length380
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesNCK2

GO terms

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GOName
GO:0001771 immunological synapse formation
GO:0001784 phosphotyrosine residue binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0008093 cytoskeletal anchor activity
GO:0008285 negative regulation of cell population proliferation
GO:0012506 vesicle membrane
GO:0014069 postsynaptic density
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030159 signaling receptor complex adaptor activity
GO:0030838 positive regulation of actin filament polymerization
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035591 signaling adaptor activity
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0044877 protein-containing complex binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0060996 dendritic spine development
GO:0097110 scaffold protein binding
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR017304 Cytoplasmic protein NCKFamilyFamily
IPR028524 Cytoplasmic protein NCK2FamilyFamily
IPR035559 Nck2, SH3 domain 1DomainDomain
IPR035560 Nck2, SH3 domain 2DomainDomain
IPR035561 Nck2, SH3 domain 3DomainDomain
IPR035883 Nck2, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

182 interactions

InteractorPartnerSourcesPublicationsLink
NCK2_HUMANDOCK1_HUMANBioGRID, HPRD, MINT11240126 details
NCK2_HUMANERBB4_HUMANBioGRID, MINT16729043 22973453 details
NCK2_HUMANEF1G_HUMANBioGRID, HPRD, IntAct16169070 details
NCK2_HUMANABI2_HUMANBioGRID, HPRD, IntAct16189514 25416956 26186194 26871637 28514442 29892012 32296183 details
NCK2_HUMANTRIP6_HUMANBioGRID, HPRD, IntAct16189514 25416956 31515488 32296183 details
NCK2_HUMANSKT_HUMANBioGRID, HPRD, IntAct16189514 details
NCK2_HUMANSPN90_HUMANBioGRID, HPRD, IntAct16189514 28514442 32296183 details
NCK2_HUMANSF3B4_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
NCK2_HUMANCBLB_HUMANBioGRID, HPRD, IntAct16189514 21516116 25416956 26186194 26871637 28514442 details
NCK2_HUMANWBP11_HUMANBioGRID, HPRD, IntAct16189514 details
NCK2_HUMANCPSF6_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
NCK2_HUMANFXR2_HUMANBioGRID, HPRD, IntAct16189514 details
NCK2_HUMANCPSF7_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
NCK2_HUMANHNRPK_HUMANBioGRID, HPRD, IntAct11557983 16189514 details
NCK2_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
NCK2_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
NCK2_HUMANDDR1_HUMANHPRD, MINT16337946 22057045 details
NCK2_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 details
NCK2_HUMANRHOU_HUMANIntAct, MINT15350535 16752908 18086875 details
NCK2_HUMANRTN4_HUMANMINT16752908 details
NCK2_HUMANPKN2_HUMANBioGRID, HPRD, MINT10026169 16752908 details
NCK2_HUMANRHOV_HUMANMINT16752908 details
NCK2_HUMANCD3E_HUMANBioGRID, HPRD, IntAct, MINT12110186 17617578 32296183 details
NCK2_HUMANUBC_HUMANBioGRID, MINT18539162 details
NCK2_HUMANLIMS1_HUMANBioGRID, HPRD, mbinfo, MINT10022929 10574708 15721255 9843575 details
NCK2_HUMANTNFL6_HUMANBioGRID, IntAct19807924 32296183 details
NCK2_HUMANPGFRB_HUMANBioGRID, HPRD, MINT10026169 11027258 9737977 details
NCK2_HUMANCHIN_HUMANBioGRID, IntAct, MINT21516116 25416956 25910212 31515488 32296183 details
NCK2_HUMANMASP1_HUMANBioGRID, MINT21900206 details
NCK2_HUMANFYB1_HUMANBioGRID, IntAct22074159 25814554 details
NCK2_HUMANPAK1_HUMANBioGRID, HPRD, IntAct10026169 11557983 23455922 25416956 26186194 28514442 30886144 31515488 31980649 32296183 details
NCK2_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
NCK2_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
NCK2_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
NCK2_HUMANKIT_HUMANBioGRID, IntAct24728074 details
NCK2_HUMANMET_HUMANBioGRID, IntAct24728074 details
NCK2_HUMANEGFR_HUMANBioGRID, HPRD, IntAct10026169 1333047 22973453 24658140 25402006 31980649 9737977 9843575 details
NCK2_HUMANRHG32_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANMEOX2_HUMANBioGRID, IntAct25416956 26871637 details
NCK2_HUMANLRIQ3_HUMANBioGRID, IntAct25416956 26871637 details
NCK2_HUMANWASL_HUMANBioGRID, IntAct25416956 26186194 26871637 28514442 details
NCK2_HUMANSPY2_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANZBT7B_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANSRBS2_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANTRI27_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANITF2_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANWASP_HUMANBioGRID, IntAct24287595 25416956 details
NCK2_HUMANMAGA6_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANPR20C_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANRASF7_HUMANBioGRID, IntAct25416956 26186194 28514442 31515488 details
NCK2_HUMANREL_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANLCP2_HUMANBioGRID, IntAct25416956 26871637 32296183 details
NCK2_HUMANSTF1_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANNC2A_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANEFHC2_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANRBM26_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANHOMEZ_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANLNX1_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANFCRL2_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANTRI41_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANLZTS2_HUMANBioGRID, IntAct25416956 26871637 details
NCK2_HUMANBC11A_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANVP37B_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANFA53C_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANABI3_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANSYVM_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANNCK2_HUMANBioGRID, IntAct25416956 details
NCK2_HUMANSCX_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANPR20D_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANCL17A_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANFOSB_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSF3A2_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANCC120_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANNPAS2_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANPRDM6_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANCHIO_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANGARE1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANTXK_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANKPRP_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANMBD6_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSOCS7_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANDLGP4_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANPAK2_HUMANBioGRID, IntAct26186194 28514442 32296183 details
NCK2_HUMANKLH24_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANZBT42_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANCD017_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSYGP1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANBCAP_HUMANBioGRID, IntAct21516116 26186194 28514442 32296183 details
NCK2_HUMANFA83A_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANMNT_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANPBX4_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANKCD17_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANHXD8_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANEIF3H_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANDTX3_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANCIB1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANTCP1L_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSESQ1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANBTG1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANCBARP_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSNW1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANNHSL2_HUMANBioGRID, IntAct26186194 28514442 32296183 details
NCK2_HUMANARHG8_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANZC21B_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANNELFA_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANLARGN_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSSH3_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANDISC1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANZN341_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANWIPF1_HUMANBioGRID, IntAct26186194 28514442 32296183 details
NCK2_HUMANHXC4_HUMANBioGRID, IntAct25416956 32296183 details
NCK2_HUMANSCML2_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANRB8NL_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANK0408_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANBCAR1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANZN526_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANMYPOP_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANWASF1_HUMANBioGRID, IntAct26186194 28514442 32296183 details
NCK2_HUMANANR55_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANZC21A_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANDB124_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANTGO1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANONEC3_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSHD_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSPC1L_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANTM121_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANKLH35_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANUBP32_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANZBT12_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSPA2L_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANGGN_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANINT2_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANCIPC_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANF124A_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANFXL19_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSF01_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANCUED1_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANREEP4_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANSRMS_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANANS1B_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANZN688_HUMANBioGRID, IntAct32296183 details
NCK2_HUMANDOK1_HUMANBioGRID, HPRD, IntAct26186194 28514442 9737977 details
NCK2_HUMANPSD10_HUMANBioGRID, IntAct24338975 details
NCK2_HUMANEFS_HUMANBioGRID, IntAct26871637 31515488 details
NCK2_HUMANFAK1_HUMANBioGRID11950595 details
NCK2_HUMANNTRK2_HUMANBioGRID, HPRD12074588 details
NCK2_HUMANILK_HUMANBioGRID10022929 details
NCK2_HUMANIRS1_HUMANBioGRID9843575 details
NCK2_HUMANKHDR1_HUMANBioGRID22745667 details
NCK2_HUMANEFNB1_HUMANBioGRID, HPRD11557983 details
NCK2_HUMANDYN1_HUMANBioGRID, HPRD11557983 details
NCK2_HUMANSYNPO_HUMANBioGRID24287595 details
NCK2_HUMANDVL1_HUMANBioGRID25416956 details
NCK2_HUMANTENR_HUMANBioGRID25416956 details
NCK2_HUMANCCD33_HUMANBioGRID25416956 32296183 details
NCK2_HUMANPR20E_HUMANBioGRID25416956 32296183 details
NCK2_HUMANPR20B_HUMANBioGRID25416956 32296183 details
NCK2_HUMANPR20A_HUMANBioGRID25416956 32296183 details
NCK2_HUMANTPT1L_HUMANBioGRID26186194 28514442 32296183 details
NCK2_HUMANTRI15_HUMANBioGRID25450970 details
NCK2_HUMANFGFR1_HUMANBioGRID, HPRD15117958 details
NCK2_HUMANSNF5_HUMANBioGRID27229929 details
NCK2_HUMANPKD1_HUMANBioGRID20856870 details
NCK2_HUMANSKAP2_HUMANBioGRID29568343 details
NCK2_HUMANNTM2F_HUMANBioGRID32296183 details
NCK2_HUMANFA47A_HUMANBioGRID32296183 details
NCK2_HUMANUFO_HUMANHPRD12470648 details
NCK2_HUMANNPHN_HUMANHPRD, IntAct16525419 details
NCK2_HUMANEFNB2_HUMANHPRD, MINT12206665 12606549 15764601 details
NCK2_HUMANADT2_HUMANIntAct23322602 details
NCK2_HUMANWIPF2_HUMANBioGRID, HPRD, IntAct12213210 26186194 28514442 details
NCK2_HUMANABI1_HUMANBioGRID, HPRD, IntAct11557983 26186194 28514442 details
NCK2_HUMANCBL_HUMANBioGRID, IntAct24287595 26186194 28514442 details
NCK2_HUMANSOS1_HUMANBioGRID, HPRD10026169 details
NCK2_HUMANBLNK_HUMANBioGRID21822214 details
NCK2_HUMANAXIN1_HUMANBioGRID, HPRD11557983 details
NCK2_HUMANSRBS1_HUMANBioGRID11557983 details
NCK2_HUMANDAB1_HUMANBioGRID14517291 details