Entity Details

Primary name SATB2_HUMAN
Entity type UniProt
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Details

AccessionQ9UPW6
EntryNameSATB2_HUMAN
FullNameDNA-binding protein SATB2
TaxID9606
Evidenceevidence at protein level
Length733
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesSATB2

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001764 neuron migration
GO:0002076 osteoblast development
GO:0003682 chromatin binding
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0009880 embryonic pattern specification
GO:0016363 nuclear matrix
GO:0021902 commitment of neuronal cell to specific neuron type in forebrain
GO:0042826 histone deacetylase binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048704 embryonic skeletal system morphogenesis
GO:0051216 cartilage development
GO:0060021 roof of mouth development
GO:0071310 cellular response to organic substance

Subcellular Location

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Subcellular Location
Nucleus matrix

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR003350 CUT domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR010982 Lambda repressor-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR032355 SATB, CUT1-like DNA-binding domainDomainDomain
IPR032392 SATB, ubiquitin-like oligomerisation domainDomainDomain
IPR038216 SATB, CUTL domain superfamilyFamilyHomologous superfamily
IPR038224 SATB, ULD domain superfamilyFamilyHomologous superfamily
IPR039673 DNA-binding protein SATB1/SATB2FamilyFamily

Diseases

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Disease IDSourceNameDescription
119540 OMIMCleft palate isolated (CPI)A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis. The disease may be caused by variants affecting the gene represented in this entry.