Entity Details

Primary name TLR6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2C9
EntryNameTLR6_HUMAN
FullNameToll-like receptor 6
TaxID9606
Evidenceevidence at protein level
Length796
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesTLR6

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001774 microglial cell activation
GO:0001775 cell activation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004888 transmembrane signaling receptor activity
GO:0005102 signaling receptor binding
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0010628 positive regulation of gene expression
GO:0030670 phagocytic vesicle membrane
GO:0032717 negative regulation of interleukin-8 production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034150 toll-like receptor 6 signaling pathway
GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex
GO:0035663 Toll-like receptor 2 binding
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038023 signaling receptor activity
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042496 detection of diacyl bacterial lipopeptide
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043032 positive regulation of macrophage activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0043507 positive regulation of JUN kinase activity
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046209 nitric oxide metabolic process
GO:0046982 protein heterodimerization activity
GO:0050135 NAD(P)+ nucleosidase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
GO:0071221 cellular response to bacterial lipopeptide
GO:0071723 lipopeptide binding
GO:0071726 cellular response to diacyl bacterial lipopeptide
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1904646 cellular response to amyloid-beta

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle
Golgi apparatus
Membrane raft

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR017241 Toll-like receptorFamilyFamily
IPR027187 Toll-like receptor 6FamilyFamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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