Entity Details

Primary name SAMH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y3Z3
EntryNameSAMH1_HUMAN
FullNameDeoxynucleoside triphosphate triphosphohydrolase SAMHD1
TaxID9606
Evidenceevidence at protein level
Length626
SequenceStatuscomplete
DateCreated2002-08-13
DateModified2021-06-02

Ontological Relatives

GenesSAMHD1

GO terms

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GOName
GO:0000724 double-strand break repair via homologous recombination
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0004540 ribonuclease activity
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0006203 dGTP catabolic process
GO:0006955 immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0008270 zinc ion binding
GO:0008832 dGTPase activity
GO:0009264 deoxyribonucleotide catabolic process
GO:0016032 viral process
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016793 triphosphoric monoester hydrolase activity
GO:0032567 dGTP binding
GO:0035861 site of double-strand break
GO:0042802 identical protein binding
GO:0045088 regulation of innate immune response
GO:0046061 dATP catabolic process
GO:0051289 protein homotetramerization
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0097197 tetraspanin-enriched microdomain
GO:0110025 DNA strand resection involved in replication fork processing

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001660 Sterile alpha motif domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR006674 HD domainDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
SAMH1_HUMANDYSF_HUMANBioGRID, IntAct23414517 details
SAMH1_HUMANTIRAP_HUMANBioGRID, IntAct21903422 details
SAMH1_HUMANSAMH1_HUMANBioGRID, DIP22056990 24141705 25423367 details
SAMH1_HUMANDCAF1_HUMANBioGRID, DIP22362772 23677995 24336198 details
SAMH1_HUMANA4_HUMANBioGRID21832049 details
SAMH1_HUMANFBX25_HUMANBioGRID23940030 details
SAMH1_HUMANFA13B_HUMANBioGRID25423367 details
SAMH1_HUMANEF1A1_HUMANBioGRID25423367 details
SAMH1_HUMANACTB_HUMANBioGRID25423367 details
SAMH1_HUMANFBX7_HUMANBioGRID27503909 details
SAMH1_HUMANARAP3_HUMANBioGRID17314030 details
SAMH1_HUMANRO52_HUMANBioGRID31797533 details
SAMH1_HUMANSUMO2_HUMANBioGRID32786267 details
SAMH1_HUMANPHLA3_HUMANIntAct17353931 details
SAMH1_HUMANCCNA2_HUMANBioGRID, IntAct24623419 26186194 28514442 30068654 details
SAMH1_HUMANCDK2_HUMANBioGRID, IntAct24623419 28514442 details
SAMH1_HUMANLG3BP_HUMANBioGRID, IntAct30833792 details
SAMH1_HUMANDDB1_HUMANBioGRID22362772 details
SAMH1_HUMANIMB1_HUMANBioGRID23874389 details
SAMH1_HUMANSKP2_HUMANBioGRID24623419 details
SAMH1_HUMANCDK1_HUMANBioGRID24623419 30068654 details
SAMH1_HUMANRBX1_HUMANBioGRID25423367 details
SAMH1_HUMANCUL4A_HUMANBioGRID25423367 details
SAMH1_HUMANCCNL2_HUMANBioGRID25532805 details
SAMH1_HUMANU2AF2_HUMANBioGRID26641092 details
SAMH1_HUMANIMA1_HUMANBioGRID24712655 details
SAMH1_HUMANHIRA_HUMANBioGRID27217568 details
SAMH1_HUMANUBP18_HUMANBioGRID30068654 details
SAMH1_HUMANM3K13_HUMANBioGRID31186535 details
SAMH1_HUMANATG5_HUMANBioGRID33024031 details