Entity Details

Primary name DMRT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5R6
EntryNameDMRT1_HUMAN
FullNameDoublesex- and mab-3-related transcription factor 1
TaxID9606
Evidenceevidence at protein level
Length373
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesDMRT1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000902 cell morphogenesis
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002176 male germ cell proliferation
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007548 sex differentiation
GO:0008354 germ cell migration
GO:0030238 male sex determination
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0045835 negative regulation of meiotic nuclear division
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046661 male sex differentiation
GO:0046872 metal ion binding
GO:0048599 oocyte development
GO:0060008 Sertoli cell differentiation
GO:0060009 Sertoli cell development
GO:0060903 positive regulation of meiosis I
GO:1900107 regulation of nodal signaling pathway
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000020 positive regulation of male gonad development

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001275 DM DNA-binding domainDomainDomain
IPR022114 Doublesex- and mab-3-related transcription factor 1-likeFamilyFamily
IPR026607 DMRT/protein doublesex/protein male abnormal 3FamilyFamily
IPR036407 DM DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DMRT1_HUMANDMRT1_HUMANDIP26005864 details
DMRT1_HUMANTRI29_HUMANBioGRID, IntAct20211142 details