Entity Details

Primary name BIG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y6D6
EntryNameBIG1_HUMAN
FullNameBrefeldin A-inhibited guanine nucleotide-exchange protein 1
TaxID9606
Evidenceevidence at protein level
Length1849
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesARFGEF1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0006887 exocytosis
GO:0007030 Golgi organization
GO:0010256 endomembrane system organization
GO:0015031 protein transport
GO:0016363 nuclear matrix
GO:0017022 myosin binding
GO:0030532 small nuclear ribonucleoprotein complex
GO:0030837 negative regulation of actin filament polymerization
GO:0031175 neuron projection development
GO:0032012 regulation of ARF protein signal transduction
GO:0034237 protein kinase A regulatory subunit binding
GO:0034260 negative regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0048471 perinuclear region of cytoplasm
GO:0051897 positive regulation of protein kinase B signaling
GO:0090284 positive regulation of protein glycosylation in Golgi
GO:0090303 positive regulation of wound healing
GO:2000114 regulation of establishment of cell polarity

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus
Nucleus
Nucleus matrix

Domains

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DomainNameCategoryType
IPR000904 Sec7 domainDomainDomain
IPR015403 Sec7, C-terminalDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR023394 Sec7, C-terminal domain superfamilyFamilyHomologous superfamily
IPR032629 Mon2, dimerisation and cyclophilin-binding domainDomainDomain
IPR032691 Guanine nucleotide exchange factor, N-terminalDomainDomain
IPR035999 Sec7 domain superfamilyFamilyHomologous superfamily

Diseases

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