Entity Details

Primary name DKC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60832
EntryNameDKC1_HUMAN
FullNameH/ACA ribonucleoprotein complex subunit DKC1
TaxID9606
Evidenceevidence at protein level
Length514
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesDKC1

GO terms

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GOName
GO:0000455 enzyme-directed rRNA pseudouridine synthesis
GO:0000495 box H/ACA RNA 3'-end processing
GO:0001650 fibrillar center
GO:0003720 telomerase activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0007004 telomere maintenance via telomerase
GO:0009982 pseudouridine synthase activity
GO:0031118 rRNA pseudouridine synthesis
GO:0031120 snRNA pseudouridine synthesis
GO:0031429 box H/ACA snoRNP complex
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0034513 box H/ACA snoRNA binding
GO:0051973 positive regulation of telomerase activity
GO:0070034 telomerase RNA binding
GO:0072589 box H/ACA scaRNP complex
GO:0090661 box H/ACA telomerase RNP complex
GO:0090666 scaRNA localization to Cajal body
GO:0090669 telomerase RNA stabilization
GO:1904851 positive regulation of establishment of protein localization to telomere
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904872 regulation of telomerase RNA localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
GO:1990481 mRNA pseudouridine synthesis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002478 PUA domainDomainDomain
IPR002501 Pseudouridine synthase II, N-terminalDomainDomain
IPR004521 Uncharacterised domain CHP00451DomainDomain
IPR004802 tRNA pseudouridine synthase B familyFamilyFamily
IPR012960 Dyskerin-likeDomainDomain
IPR015947 PUA-like superfamilyFamilyHomologous superfamily
IPR020103 Pseudouridine synthase, catalytic domain superfamilyFamilyHomologous superfamily
IPR032819 tRNA pseudouridylate synthase B, C-terminalDomainDomain

Diseases

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Interactions

25 interactions

InteractorPartnerSourcesPublicationsLink
DKC1_HUMANEF1G_HUMANBioGRID, HPRD, IntAct16169070 details
DKC1_HUMANEIF3F_HUMANBioGRID, HPRD, IntAct16169070 details
DKC1_HUMANSSRA_HUMANBioGRID, HPRD, IntAct16169070 details
DKC1_HUMANLYPA2_HUMANBioGRID, HPRD, IntAct16169070 details
DKC1_HUMANRUVB1_HUMANbhf-ucl, BioGRID, HPRD, IntAct18358808 19179534 26186194 28514442 28561026 details
DKC1_HUMANMK06_HUMANBioGRID, MINT21900206 details
DKC1_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
DKC1_HUMANTCAB1_HUMANbhf-ucl, BioGRID, IntAct19179534 25416818 25467444 26496610 details
DKC1_HUMANSHQ1_HUMANBioGRID, IntAct22085966 25553844 26186194 28514442 29178645 details
DKC1_HUMANERG_HUMANBioGRID24591637 details
DKC1_HUMANDAXX_HUMANBioGRID25416818 details
DKC1_HUMANLYAR_HUMANIntAct17353931 details
DKC1_HUMANNOP10_HUMANbhf-ucl, BioGRID, DIP, IntAct19095616 19179534 23474713 26186194 28514442 details
DKC1_HUMANNHP2_HUMANbhf-ucl, BioGRID19095616 19179534 22939629 26344197 details
DKC1_HUMANNOLC1_HUMANbhf-ucl, BioGRID19179534 26399832 details
DKC1_HUMANNAF1_HUMANbhf-ucl, BioGRID, IntAct16601202 16618814 19095616 19179534 26186194 26344197 26496610 28514442 details
DKC1_HUMANHMBX1_HUMANMINT23685356 details
DKC1_HUMANFBRL_HUMANBioGRID, IntAct19095616 26344197 29568061 34079125 details
DKC1_HUMANTERF2_HUMANBioGRID20811636 details
DKC1_HUMANDKC1_HUMANBioGRID21931644 details
DKC1_HUMANABCE1_HUMANBioGRID25659154 details
DKC1_HUMANPESC_HUMANBioGRID25825154 details
DKC1_HUMANTCOF_HUMANBioGRID26399832 details
DKC1_HUMANCI114_HUMANBioGRID26472758 details
DKC1_HUMANUBR5_HUMANBioGRID31365120 details