Entity Details

Primary name BAG3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95817
EntryNameBAG3_HUMAN
FullNameBAG family molecular chaperone regulator 3
TaxID9606
Evidenceevidence at protein level
Length575
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesBAG3

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006457 protein folding
GO:0007420 brain development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0016020 membrane
GO:0016235 aggresome
GO:0021510 spinal cord development
GO:0030018 Z disc
GO:0031072 heat shock protein binding
GO:0034605 cellular response to heat
GO:0034620 cellular response to unfolded protein
GO:0042307 positive regulation of protein import into nucleus
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045296 cadherin binding
GO:0045505 dynein intermediate chain binding
GO:0046716 muscle cell cellular homeostasis
GO:0046827 positive regulation of protein export from nucleus
GO:0050821 protein stabilization
GO:0051087 chaperone binding
GO:0061684 chaperone-mediated autophagy
GO:0070842 aggresome assembly
GO:0071260 cellular response to mechanical stimulus
GO:0072321 obsolete chaperone-mediated protein transport
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress
GO:0098840 protein transport along microtubule
GO:0101031 chaperone complex
GO:1900034 regulation of cellular response to heat
GO:1903215 negative regulation of protein targeting to mitochondrion
GO:1905337 positive regulation of aggrephagy

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001202 WW domainDomainDomain
IPR003103 BAG domainDomainDomain
IPR036020 WW domain superfamilyFamilyHomologous superfamily
IPR036533 BAG domain superfamilyFamilyHomologous superfamily
IPR039773 Molecular chaperone regulator BAGFamilyFamily

Diseases

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Disease IDSourceNameDescription
613881 OMIMCardiomyopathy, dilated 1HH (CMD1HH)A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. The disease is caused by variants affecting the gene represented in this entry.
612954 OMIMMyopathy, myofibrillar, 6 (MFM6)A form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disk and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM6 is characterized by early-onset of severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. The disease is caused by variants affecting the gene represented in this entry.

Interactions

122 interactions

InteractorPartnerSourcesPublicationsLink
BAG3_HUMANDVL2_HUMANBioGRID, HPRD, IntAct, MINT16189514 21516116 31340145 details
BAG3_HUMANHSPB8_HUMANBioGRID, HPRD, IntAct, MINT11591653 16189514 21516116 25036637 26496610 28514442 29405094 30559338 32296183 details
BAG3_HUMANDAZP2_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
BAG3_HUMANHSPB1_HUMANBioGRID, IntAct25036637 25277244 26496610 30559338 32814053 details
BAG3_HUMANLRRK2_HUMANBioGRID, IntAct24510904 details
BAG3_HUMANPDLI7_HUMANBioGRID, IntAct23824909 25036637 28514442 32296183 details
BAG3_HUMANWBP2_HUMANBioGRID, IntAct23824909 25036637 32296183 details
BAG3_HUMANLRRK1_HUMANBioGRID, IntAct24947832 29513927 details
BAG3_HUMANPDE9A_HUMANBioGRID, IntAct25416956 32296183 details
BAG3_HUMANSF3B4_HUMANBioGRID, IntAct23824909 25416956 32296183 details
BAG3_HUMANARRD3_HUMANBioGRID, IntAct25416956 32296183 details
BAG3_HUMANLITAF_HUMANBioGRID, IntAct23824909 25416956 31515488 32296183 details
BAG3_HUMANMAGD1_HUMANBioGRID, IntAct25416956 32296183 details
BAG3_HUMANACK1_HUMANBioGRID, IntAct19144635 26496610 details
BAG3_HUMANHSP7C_HUMANBioGRID, HPRD, IntAct21233200 21423662 23824909 25036637 25416956 26496610 27684187 29568061 30559338 9873016 details
BAG3_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
BAG3_HUMANACD_HUMANbhf-ucl, BioGRID21044950 details
BAG3_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
BAG3_HUMANRUNX1_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANHSPB2_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANPTN21_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANPRDM6_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANTRI27_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANCPSF6_HUMANIntAct32296183 details
BAG3_HUMANGO45_HUMANIntAct32296183 details
BAG3_HUMANOSGEP_HUMANIntAct32296183 details
BAG3_HUMANPIHD2_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANNIBA3_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANFX4L1_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANTBC3G_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANPA2GX_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANPRR34_HUMANIntAct32296183 details
BAG3_HUMANUNKL_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANNOTO_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANPKHB1_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANGGN_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANNR1H3_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANTRIB3_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANCYTM1_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANSHSA6_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANBI2L1_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANTM174_HUMANBioGRID, IntAct23824909 32296183 details
BAG3_HUMANLENG8_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANDYN2_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANKAP1_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANTRIP6_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANVP37B_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANMDFI_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANCTDS1_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANEGR4_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANSIAH1_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANEYA2_HUMANBioGRID, IntAct27880917 32296183 details
BAG3_HUMANHSPB7_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANDTX3_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANRM38_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANF168B_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANGLIS3_HUMANBioGRID, IntAct32296183 details
BAG3_HUMANCRYAB_HUMANBioGRID, IntAct21423662 26186194 28514442 details
BAG3_HUMANCRYA2_HUMANIntAct32814053 details
BAG3_HUMANDYHC1_HUMANIntAct32814053 details
BAG3_HUMANNFL_HUMANIntAct32814053 details
BAG3_HUMANKLK6_HUMANIntAct32814053 details
BAG3_HUMANWFS1_HUMANIntAct32814053 details
BAG3_HUMANSAP30_HUMANIntAct32814053 details
BAG3_HUMANRBBP4_HUMANIntAct32814053 details
BAG3_HUMANBACD1_HUMANIntAct32814053 details
BAG3_HUMANBOD1_HUMANIntAct32814053 details
BAG3_HUMANRETR1_HUMANIntAct32814053 details
BAG3_HUMANPELO_HUMANIntAct32814053 details
BAG3_HUMANTCPE_HUMANIntAct32814053 details
BAG3_HUMANF1892_HUMANBioGRID, HPRD16189514 details
BAG3_HUMANPLCG1_HUMANBioGRID, HPRD10980614 21233200 details
BAG3_HUMANWNK1_HUMANBioGRID20936779 details
BAG3_HUMANHSP74_HUMANBioGRID12750378 19229298 20368414 21233200 23824909 28859986 30559338 31500722 details
BAG3_HUMANDYLT1_HUMANBioGRID21252941 details
BAG3_HUMANSRPK2_HUMANBioGRID26167880 details
BAG3_HUMANFBX7_HUMANBioGRID27503909 details
BAG3_HUMANBIP_HUMANBioGRID24080088 details
BAG3_HUMANDVL1_HUMANBioGRID32296183 details
BAG3_HUMANATN1_HUMANBioGRID32296183 details
BAG3_HUMANSPY2_HUMANBioGRID32296183 details
BAG3_HUMANASPP2_HUMANBioGRID32296183 details
BAG3_HUMANAT7L2_HUMANBioGRID32296183 details
BAG3_HUMANTSC1_HUMANBioGRID32296183 details
BAG3_HUMANHELT_HUMANBioGRID32296183 details
BAG3_HUMANTBC3C_HUMANBioGRID32296183 details
BAG3_HUMANTBC3B_HUMANBioGRID32296183 details
BAG3_HUMANSQSTM_HUMANBioGRID, MINT19229298 23824909 29405094 34079125 details
BAG3_HUMANHS71A_HUMANBioGRID, HPRD, IntAct, MINT10980614 11527400 19229298 21252941 23824909 26496610 30559338 32296183 33957083 9873016 details
BAG3_HUMANHS71B_HUMANBioGRID, HPRD, MINT10980614 11527400 19229298 21252941 23824909 26496610 30559338 33957083 9873016 details
BAG3_HUMANUBC9_HUMANIntAct20936779 details
BAG3_HUMANDC2L1_HUMANMINT21252941 details
BAG3_HUMANSODC_HUMANMINT21252941 details
BAG3_HUMANMLF1_HUMANIntAct25036637 details
BAG3_HUMANMLF2_HUMANBioGRID, IntAct25036637 26496610 details
BAG3_HUMANHSF2_HUMANIntAct25036637 details
BAG3_HUMANPSMD2_HUMANBioGRID, IntAct23824909 25036637 details
BAG3_HUMANCHIP_HUMANBioGRID, IntAct22863883 25036637 26496610 31500722 details
BAG3_HUMANDNJB6_HUMANBioGRID, IntAct, UniProt22366786 25036637 30559338 details
BAG3_HUMANHSF1_HUMANBioGRID, IntAct23824909 25036637 27173435 unassigned1312 details
BAG3_HUMANSYNPO_HUMANBioGRID, IntAct26496610 30744518 details
BAG3_HUMANNEMO_HUMANBioGRID, DIP20368414 details
BAG3_HUMANTERF1_HUMANBioGRID20811636 details
BAG3_HUMANTERF2_HUMANBioGRID20811636 details
BAG3_HUMANCAZA1_HUMANBioGRID20884878 details
BAG3_HUMANCAPZB_HUMANBioGRID20884878 details
BAG3_HUMANSYNP2_HUMANBioGRID23434281 details
BAG3_HUMANMCL1_HUMANBioGRID23341456 details
BAG3_HUMANBCL2_HUMANBioGRID, HPRD11513873 23341456 details
BAG3_HUMAN1433Z_HUMANBioGRID23824909 details
BAG3_HUMANATG3_HUMANBioGRID23824909 28103122 details
BAG3_HUMANPSB1_HUMANBioGRID23824909 details
BAG3_HUMANMK07_HUMANBioGRID23824909 details
BAG3_HUMANBAG3_HUMANBioGRID23824909 details
BAG3_HUMANMYH6_HUMANBioGRID27034027 details
BAG3_HUMANUSP9X_HUMANBioGRID27120977 details
BAG3_HUMANDNJB1_HUMANBioGRID30559338 details
BAG3_HUMANBNIP3_HUMANBioGRID31500722 details
BAG3_HUMANBNI3L_HUMANBioGRID31500722 details
BAG3_HUMANUNK_HUMANBioGRID29395067 details