Entity Details

Primary name FA12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00748
EntryNameFA12_HUMAN
FullNameCoagulation factor XII
TaxID9606
Evidenceevidence at protein level
Length615
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesF12

GO terms

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GOName
GO:0002353 plasma kallikrein-kinin cascade
GO:0002542 Factor XII activation
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005791 rough endoplasmic reticulum
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0010756 positive regulation of plasminogen activation
GO:0016485 protein processing
GO:0016540 protein autoprocessing
GO:0030194 positive regulation of blood coagulation
GO:0031638 zymogen activation
GO:0042730 fibrinolysis
GO:0045087 innate immune response
GO:0051787 misfolded protein binding
GO:0051788 response to misfolded protein
GO:0051919 positive regulation of fibrinolysis
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:2000267 negative regulation of blood coagulation, intrinsic pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR000083 Fibronectin, type IDomainDomain
IPR000562 Fibronectin type II domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR014394 Coagulation factor XII/hepatocyte growth factor activatorFamilyFamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR036943 Fibronectin type II domain superfamilyFamilyHomologous superfamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB06404 Human C1-esterase inhibitorDrugbankbiotech
DB06689 Ethanolamine oleateDrugbanksmall molecule
DB09228 Conestat alfaDrugbankbiotech
DB12598 NafamostatDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule