Entity Details

Primary name IL1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01583
EntryNameIL1A_HUMAN
FullNameInterleukin-1 alpha
TaxID9606
Evidenceevidence at protein level
Length271
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesIL1A

GO terms

Show/Hide Table
GOName
GO:0001660 fever generation
GO:0001819 positive regulation of cytokine production
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
GO:0005507 copper ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0006883 cellular sodium ion homeostasis
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008285 negative regulation of cell population proliferation
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0034605 cellular response to heat
GO:0035234 ectopic germ cell programmed cell death
GO:0045766 positive regulation of angiogenesis
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046688 response to copper ion
GO:0050714 positive regulation of protein secretion
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051781 positive regulation of cell division
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000975 Interleukin-1 familyFamilyFamily
IPR003295 Interleukin-1 alphaFamilyFamily
IPR003502 Interleukin-1 propeptideDomainDomain
IPR008996 Cytokine IL1/FGFFamilyHomologous superfamily
IPR020877 Interleukin-1 conserved siteSiteConserved site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB06372 RilonaceptDrugbankbiotech