Entity Details

Primary name CO1A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02452
EntryNameCO1A1_HUMAN
FullNameCollagen alpha-1(I) chain
TaxID9606
Evidenceevidence at protein level
Length1464
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesCOL1A1

GO terms

Show/Hide Table
GOName
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001957 intramembranous ossification
GO:0001958 endochondral ossification
GO:0002020 protease binding
GO:0005201 extracellular matrix structural constituent
GO:0005576 extracellular region
GO:0005584 collagen type I trimer
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0007596 blood coagulation
GO:0007601 visual perception
GO:0007605 sensory perception of sound
GO:0009612 response to mechanical stimulus
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010812 negative regulation of cell-substrate adhesion
GO:0015031 protein transport
GO:0030020 extracellular matrix structural constituent conferring tensile strength
GO:0030141 secretory granule
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030335 positive regulation of cell migration
GO:0031012 extracellular matrix
GO:0031960 response to corticosteroid
GO:0032355 response to estradiol
GO:0032964 collagen biosynthetic process
GO:0034504 protein localization to nucleus
GO:0034505 tooth mineralization
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0043434 response to peptide hormone
GO:0043588 skin development
GO:0043589 skin morphogenesis
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044691 tooth eruption
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0048407 platelet-derived growth factor binding
GO:0048706 embryonic skeletal system development
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
GO:0051591 response to cAMP
GO:0055093 response to hyperoxia
GO:0060325 face morphogenesis
GO:0060346 bone trabecula formation
GO:0060351 cartilage development involved in endochondral bone morphogenesis
GO:0062023 collagen-containing extracellular matrix
GO:0071230 cellular response to amino acid stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071300 cellular response to retinoic acid
GO:0071306 cellular response to vitamin E
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902618 cellular response to fluoride

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000885 Fibrillar collagen, C-terminalDomainDomain
IPR001007 VWFC domainDomainDomain
IPR008160 Collagen triple helix repeatRepeatRepeat

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00048 Collagenase clostridium histolyticumDrugbankbiotech
DB04866 HalofuginoneDrugbanksmall molecule
DB11338 Clove oilDrugbankbiotech
DB12872 Vonicog AlfaDrugbankbiotech
DB13133 Von Willebrand Factor HumanDrugbankbiotech

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
CO1A1_HUMANCOCH_HUMANMINT19013156 details
CO1A1_HUMANAT132_HUMANBioGRID, IntAct22645275 details
CO1A1_HUMANZNF16_HUMANUniProt21874239 details
CO1A1_HUMANLYOX_HUMANmatrixdb21690299 details
CO1A1_HUMANAP2A_HUMANIntAct24835590 details
CO1A1_HUMANAP2C_HUMANIntAct24835590 details
CO1A1_HUMANFINC_HUMANDIP, HPRD, matrixdb, MINT20541508 25290767 26848503 8468356 details
CO1A1_HUMANCO5A1_HUMANmatrixdb20979576 details
CO1A1_HUMANKEAP1_HUMANBioGRID, IntAct32296183 details
CO1A1_HUMANARMS2_HUMANIntAct19696174 details
CO1A1_HUMANHTRA1_HUMANHPRD, IntAct15101818 21622153 details
CO1A1_HUMANSPRC_HUMANBioGRID, HPRD, matrixdb26848503 2745554 7034958 details
CO1A1_HUMANIBP3_HUMANBioGRID, HPRD12735930 details
CO1A1_HUMANTHIO_HUMANBioGRID, HPRD12099690 details
CO1A1_HUMANNID1_HUMANBioGRID, HPRD9733643 details
CO1A1_HUMANNID2_HUMANBioGRID9733643 details
CO1A1_HUMANPRELP_HUMANBioGRID, HPRD11847210 details
CO1A1_HUMANPKD1_HUMANBioGRID11752017 details
CO1A1_HUMANVWF_HUMANBioGRID, HPRD3490481 details
CO1A1_HUMANTSP1_HUMANBioGRID, HPRD3571333 details
CO1A1_HUMANMMP2_HUMANBioGRID, HPRD11368514 details
CO1A1_HUMANCO7A1_HUMANBioGRID, HPRD9169408 details
CO1A1_HUMANMATN2_HUMANBioGRID, HPRD12180907 details
CO1A1_HUMANMAG_HUMANBioGRID2446864 details
CO1A1_HUMANBARD1_HUMANBioGRID22990118 details
CO1A1_HUMANBRCA1_HUMANBioGRID22990118 details
CO1A1_HUMANUBC_HUMANBioGRID23314748 details
CO1A1_HUMANCAN1_HUMANBioGRID, HPRD12358155 details
CO1A1_HUMANPDGFA_HUMANBioGRID8900172 details
CO1A1_HUMANPDGFB_HUMANBioGRID, HPRD10446987 8900172 details
CO1A1_HUMANMCPH1_HUMANBioGRID29150431 details
CO1A1_HUMANCDC42_HUMANBioGRID31478661 details
CO1A1_HUMANDISC1_HUMANIntAct31413325 details
CO1A1_HUMANCO1A2_HUMANBioGRID, matrixdb18375391 24981860 26848503 details
CO1A1_HUMANPDIA1_HUMANHPRD, matrixdb1339453 26848503 details
CO1A1_HUMANITA2_HUMANBioGRID, HPRD11359786 11856343 2156854 details
CO1A1_HUMANITB1_HUMANBioGRID2156854 details
CO1A1_HUMANCO1A1_HUMANBioGRID18375391 details
CO1A1_HUMANBMP1_HUMANHPRD11283002 details
CO1A1_HUMANMMP9_HUMANHPRD9878537 details
CO1A1_HUMANC1QR1_HUMANHPRD1377218 details
CO1A1_HUMANPGS2_HUMANHPRD1468447 9675033 details
CO1A1_HUMANITA5_HUMANHPRD1693626 details
CO1A1_HUMANFGF7_HUMANHPRD11973338 details
CO1A1_HUMANCD36_HUMANHPRD2468670 details
CO1A1_HUMANDDR2_HUMANHPRD9659899 details
CO1A1_HUMANPGS1_HUMANHPRD7852349 details
CO1A1_HUMANBGH3_HUMANHPRD11867580 12034705 details
CO1A1_HUMANPAK1_HUMANHPRD10772928 details
CO1A1_HUMANTMPS6_HUMANHPRD12149247 details
CO1A1_HUMANCD44_HUMANHPRD1730778 details