Entity Details

Primary name ACHA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02708
EntryNameACHA_HUMAN
FullNameAcetylcholine receptor subunit alpha
TaxID9606
Evidenceevidence at protein level
Length482
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesCHRNA1

GO terms

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GOName
GO:0003009 skeletal muscle contraction
GO:0005216 ion channel activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0007274 neuromuscular synaptic transmission
GO:0007528 neuromuscular junction development
GO:0009986 cell surface
GO:0015464 acetylcholine receptor activity
GO:0019228 neuronal action potential
GO:0022848 acetylcholine-gated cation-selective channel activity
GO:0030594 neurotransmitter receptor activity
GO:0031594 neuromuscular junction
GO:0034220 ion transmembrane transport
GO:0042166 acetylcholine binding
GO:0042391 regulation of membrane potential
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0046716 muscle cell cellular homeostasis
GO:0048630 skeletal muscle tissue growth
GO:0050877 nervous system process
GO:0050881 musculoskeletal movement
GO:0050905 neuromuscular process
GO:0070050 neuron cellular homeostasis
GO:0099060 integral component of postsynaptic specialization membrane
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR002394 Nicotinic acetylcholine receptorFamilyFamily
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00555 LamotrigineDrugbanksmall molecule
DB08838 AgmatineDrugbanksmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
ACHA_HUMANACHE_HUMANBioGRID, HPRD1712080 details
ACHA_HUMANACHD_HUMANBioGRID, HPRD7695910 8910344 details
ACHA_HUMANACHG_HUMANBioGRID, HPRD7695910 details
ACHA_HUMANITA7_HUMANBioGRID, HPRD10910772 details