Entity Details

Primary name MT2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02795
EntryNameMT2_HUMAN
FullNameMetallothionein-2
TaxID9606
Evidenceevidence at protein level
Length61
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesMT2A

GO terms

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GOName
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006878 cellular copper ion homeostasis
GO:0006882 cellular zinc ion homeostasis
GO:0008270 zinc ion binding
GO:0010038 response to metal ion
GO:0010273 detoxification of copper ion
GO:0036016 cellular response to interleukin-3
GO:0036018 cellular response to erythropoietin
GO:0045926 negative regulation of growth
GO:0046872 metal ion binding
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0071276 cellular response to cadmium ion
GO:0071280 cellular response to copper ion
GO:0071294 cellular response to zinc ion

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000006 Metallothionein, vertebrateFamilyFamily
IPR003019 MetallothioneinFamilyFamily
IPR017854 Metallothionein domain superfamilyFamilyHomologous superfamily
IPR018064 Metallothionein, vertebrate, metal binding siteSiteBinding site
IPR023587 Metallothionein domain superfamily, vertebrateFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB12965 SilverDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
MT2_HUMANMTR1L_HUMANMINT16778767 details
MT2_HUMANEOLA1_HUMANHPRD, UniProt15541360 details
MT2_HUMANKPCD1_HUMANBioGRID, HPRD, IntAct14550308 details
MT2_HUMANISK7_HUMANBioGRID, HPRD, IntAct12646258 12970870 details
MT2_HUMANASSY_HUMANBioGRID, IntAct21988832 details
MT2_HUMANPYRD_HUMANBioGRID, IntAct21988832 details
MT2_HUMANZN363_HUMANBioGRID, IntAct21988832 details
MT2_HUMANZNF16_HUMANUniProt21874239 details
MT2_HUMANJHD2C_HUMANBioGRID, MINT23455924 details
MT2_HUMANTNS2_HUMANBioGRID, IntAct25814554 details
MT2_HUMANRIN3_HUMANBioGRID, IntAct25814554 details
MT2_HUMANAP2A_HUMANIntAct24835590 details
MT2_HUMANAP2C_HUMANIntAct24835590 details
MT2_HUMANHMGB1_HUMANBioGRID, UniProt29721183 31694235 details
MT2_HUMANNAL12_HUMANI2D32226298 details
MT2_HUMANAPOE_HUMANIntAct32814053 details
MT2_HUMANFLNA_HUMANIntAct32814053 details
MT2_HUMANMETK2_HUMANIntAct32814053 details
MT2_HUMANRSMB_HUMANIntAct32814053 details
MT2_HUMANICAM5_HUMANIntAct32814053 details
MT2_HUMANIDLC_HUMANIntAct32814053 details
MT2_HUMANKLF11_HUMANIntAct32814053 details
MT2_HUMANNUP58_HUMANIntAct32814053 details
MT2_HUMANCOQA1_HUMANIntAct32814053 details
MT2_HUMANSYUA_HUMANIntAct32814053 details
MT2_HUMANHD_HUMANIntAct32814053 details
MT2_HUMANUBP25_HUMANBioGRID16501887 details
MT2_HUMANNED4L_HUMANBioGRID19664597 details
MT2_HUMANSHBG_HUMANBioGRID, HPRD15862967 details
MT2_HUMANBARD1_HUMANBioGRID22990118 details
MT2_HUMANECT2_HUMANBioGRID22990118 details
MT2_HUMANPAXI1_HUMANBioGRID22990118 details
MT2_HUMANLTOR5_HUMANBioGRID23241634 details
MT2_HUMANARF6_HUMANBioGRID15923660 details
MT2_HUMANMCPH1_HUMANBioGRID29150431 details
MT2_HUMANATS4_HUMANHPRD16099106 details