Entity Details

Primary name MMP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP03956
EntryNameMMP1_HUMAN
FullNameInterstitial collagenase
TaxID9606
Evidenceevidence at protein level
Length469
SequenceStatuscomplete
DateCreated1986-10-23
DateModified2021-06-02

Ontological Relatives

GenesMMP1

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0031334 positive regulation of protein-containing complex assembly
GO:0044267 cellular protein metabolic process
GO:0050900 leukocyte migration
GO:0071492 cellular response to UV-A

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00786 MarimastatDrugbanksmall molecule
DB07556 CGS-27023Drugbanksmall molecule
DB07926 N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDEDrugbanksmall molecule
DB08403 METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACIDDrugbanksmall molecule
DB08482 [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTERDrugbanksmall molecule
DB08491 N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDEDrugbanksmall molecule