Entity Details

Primary name ALDOA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04075
EntryNameALDOA_HUMAN
FullNameFructose-bisphosphate aldolase A
TaxID9606
Evidenceevidence at protein level
Length364
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesALDOA

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0004332 fructose-bisphosphate aldolase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006000 fructose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006754 ATP biosynthetic process
GO:0006941 striated muscle contraction
GO:0007015 actin filament organization
GO:0007339 binding of sperm to zona pellucida
GO:0008092 cytoskeletal protein binding
GO:0008360 regulation of cell shape
GO:0015629 actin cytoskeleton
GO:0015631 tubulin binding
GO:0016020 membrane
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0031093 platelet alpha granule lumen
GO:0031430 M band
GO:0031674 I band
GO:0034774 secretory granule lumen
GO:0042802 identical protein binding
GO:0043312 neutrophil degranulation
GO:0045296 cadherin binding
GO:0046716 muscle cell cellular homeostasis
GO:0051289 protein homotetramerization
GO:0061621 canonical glycolysis
GO:0061827 sperm head
GO:0070061 fructose binding
GO:0070062 extracellular exosome
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000741 Fructose-bisphosphate aldolase, class-IFamilyFamily
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR029768 Fructose-bisphosphate aldolase class-I active siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
611881 OMIMGlycogen storage disease 12 (GSD12)A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB02512 1,6-Fructose Diphosphate (Linear Form)Drugbanksmall molecule
DB04326 Dihydroxyacetone phosphateDrugbanksmall molecule
DB04733 1,6-DI-O-PHOSPHONO-D-MANNITOLDrugbanksmall molecule
DB08240 N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDEDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
ALDOA_HUMANXRN1_HUMANBioGRID, HPRD, IntAct15231747 details
ALDOA_HUMANPCNA_HUMANBioGRID, MINT20849852 details
ALDOA_HUMANMLH1_HUMANBioGRID, IntAct20706999 details
ALDOA_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
ALDOA_HUMANGALT6_HUMANBioGRID, IntAct21988832 details
ALDOA_HUMANBCAT2_HUMANBioGRID, IntAct21988832 details
ALDOA_HUMANALDOB_HUMANBioGRID, IntAct21988832 details
ALDOA_HUMANALDOA_HUMANBioGRID, HPRD, IntAct14669989 21988832 25416956 32296183 details
ALDOA_HUMANPIAS4_HUMANBioGRID, IntAct21988832 details
ALDOA_HUMANEGFR_HUMANBioGRID, IntAct20029029 31980649 details
ALDOA_HUMANENOA_HUMANBioGRID, IntAct23414517 26344197 details
ALDOA_HUMANENOB_HUMANBioGRID, IntAct23414517 details
ALDOA_HUMANAP2A_HUMANIntAct24835590 details
ALDOA_HUMANALDOC_HUMANBioGRID, IntAct22863883 22939629 25416956 25910212 26186194 26344197 26496610 28514442 31515488 31536960 details
ALDOA_HUMANIFNA4_HUMANBioGRID, IntAct25416956 details
ALDOA_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
ALDOA_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
ALDOA_HUMANCRYAB_HUMANbhf-ucl26465331 details
ALDOA_HUMANHD_HUMANBioGRID, IntAct, UniProt25959826 32814053 details
ALDOA_HUMANZP4_HUMANIntAct23355646 details
ALDOA_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
ALDOA_HUMANERBB3_HUMANBioGRID, IntAct31980649 details
ALDOA_HUMANERBB4_HUMANBioGRID, IntAct31980649 details
ALDOA_HUMANFANCA_HUMANBioGRID14499622 details
ALDOA_HUMANVATE1_HUMANBioGRID, HPRD11399750 details
ALDOA_HUMANPLD2_HUMANBioGRID, HPRD11876650 details
ALDOA_HUMANTRI63_HUMANBioGRID15967462 details
ALDOA_HUMANMYOC_HUMANBioGRID, HPRD16289162 details
ALDOA_HUMANADRB2_HUMANBioGRID24561123 details
ALDOA_HUMANHCD2_HUMANBioGRID22496890 26344197 details
ALDOA_HUMANSRPK2_HUMANBioGRID26167880 details
ALDOA_HUMANCYH2_HUMANBioGRID21307348 details
ALDOA_HUMANS22A1_HUMANBioGRID31318583 details
ALDOA_HUMANOGT1_HUMANBioGRID32994395 details
ALDOA_HUMAN1433Z_HUMANMINT15161933 details
ALDOA_HUMANSHAN3_HUMANMINT21653829 details
ALDOA_HUMANPSMD4_HUMANBioGRID12601813 details
ALDOA_HUMANHDAC5_HUMANBioGRID21081666 details
ALDOA_HUMANISG15_HUMANBioGRID16009940 33024031 details
ALDOA_HUMANAKT1_HUMANBioGRID16027165 details
ALDOA_HUMANHS90A_HUMANBioGRID16263121 details
ALDOA_HUMANMT21D_HUMANBioGRID23349634 details
ALDOA_HUMANSUMO4_HUMANBioGRID, HPRD16236267 26344197 details
ALDOA_HUMANFLCN_HUMANBioGRID28656962 details
ALDOA_HUMANATG5_HUMANBioGRID33024031 details
ALDOA_HUMANGPDM_HUMANHPRD2065091 6406231 details
ALDOA_HUMANTGM2_HUMANHPRD1353685 details
ALDOA_HUMANTBB2A_HUMANHPRD8103323 details
ALDOA_HUMANDYL1_HUMANHPRD14760703 details