Entity Details

Primary name PAI1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05121
EntryNamePAI1_HUMAN
FullNamePlasminogen activator inhibitor 1
TaxID9606
Evidenceevidence at protein level
Length402
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesSERPINE1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0007623 circadian rhythm
GO:0010469 regulation of signaling receptor activity
GO:0010757 negative regulation of plasminogen activation
GO:0010951 negative regulation of endopeptidase activity
GO:0014912 negative regulation of smooth muscle cell migration
GO:0030194 positive regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0030198 extracellular matrix organization
GO:0030336 negative regulation of cell migration
GO:0031093 platelet alpha granule lumen
GO:0032757 positive regulation of interleukin-8 production
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035491 positive regulation of leukotriene production involved in inflammatory response
GO:0042730 fibrinolysis
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051918 negative regulation of fibrinolysis
GO:0061044 negative regulation of vascular wound healing
GO:0061045 negative regulation of wound healing
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090399 replicative senescence
GO:0097187 dentinogenesis
GO:1901331 positive regulation of odontoblast differentiation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000098 negative regulation of smooth muscle cell-matrix adhesion
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000215 Serpin familyFamilyFamily
IPR023795 Serpin, conserved siteSiteConserved site
IPR023796 Serpin domainDomainDomain
IPR036186 Serpin superfamilyFamilyHomologous superfamily
IPR042178 Serpin superfamily, domain 1FamilyHomologous superfamily
IPR042185 Serpin superfamily, domain 2FamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00009 AlteplaseDrugbankbiotech
DB00013 UrokinaseDrugbankbiotech
DB00015 ReteplaseDrugbankbiotech
DB00029 AnistreplaseDrugbankbiotech
DB00031 TenecteplaseDrugbankbiotech
DB00055 Drotrecogin alfaDrugbankbiotech
DB00197 TroglitazoneDrugbanksmall molecule
DB05254 FibrinolysinDrugbankbiotech
DB09130 CopperDrugbanksmall molecule

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
PAI1_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16713569 details
PAI1_HUMANA1AG1_HUMANBioGRID, HPRD, IntAct11418606 16272158 details
PAI1_HUMANVTNC_HUMANBioGRID, HPRD, IntAct11113116 11796824 12808446 8830783 9065424 details
PAI1_HUMANUROK_HUMANBioGRID, HPRD, MINT2161846 22449964 2544876 3090045 9184208 details
PAI1_HUMANTPA_HUMANBioGRID, HPRD, MINT2110366 22449964 3090045 8607113 details
PAI1_HUMANSGTA_HUMANBioGRID, IntAct25416956 32296183 details
PAI1_HUMANSGTB_HUMANBioGRID, IntAct25416956 32296183 details
PAI1_HUMANUBQL1_HUMANBioGRID, IntAct25416956 details
PAI1_HUMANUBQL2_HUMANBioGRID, IntAct32296183 details
PAI1_HUMANTLX3_HUMANBioGRID, IntAct32296183 details
PAI1_HUMANDHB11_HUMANBioGRID, IntAct32296183 details
PAI1_HUMANPITX1_HUMANBioGRID, IntAct32296183 details
PAI1_HUMANTM237_HUMANBioGRID, IntAct32296183 details
PAI1_HUMANTHRB_HUMANBioGRID, HPRD10543954 12709053 details
PAI1_HUMANPLMN_HUMANBioGRID, HPRD11113116 details
PAI1_HUMANLMNA_HUMANBioGRID24623722 details
PAI1_HUMANACTN4_HUMANHPRD15493875 details
PAI1_HUMANK1C18_HUMANHPRD15493875 details
PAI1_HUMANLRP1_HUMANBioGRID, HPRD15001579 details
PAI1_HUMANPAI1_HUMANBioGRID, HPRD10731421 details
PAI1_HUMANIBP5_HUMANBioGRID, HPRD9202242 details
PAI1_HUMANPSA3_HUMANBioGRID21135093 details
PAI1_HUMANPSB1_HUMANBioGRID21135093 details
PAI1_HUMANUSF2_HUMANBioGRID23991099 details
PAI1_HUMANMMP3_HUMANHPRD10967118 details
PAI1_HUMANLRP2_HUMANHPRD8344937 details
PAI1_HUMANLRP1B_HUMANHPRD11384978 details
PAI1_HUMANELNE_HUMANHPRD7521069 details
PAI1_HUMANKLK2_HUMANHPRD10209959 details