Entity Details

Primary name ERCC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07992
EntryNameERCC1_HUMAN
FullNameDNA excision repair protein ERCC-1
TaxID9606
Evidenceevidence at protein level
Length297
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesERCC1

GO terms

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GOName
GO:0000109 nucleotide-excision repair complex
GO:0000110 nucleotide-excision repair factor 1 complex
GO:0000710 meiotic mismatch repair
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
GO:0000781 chromosome, telomeric region
GO:0001094 TFIID-class transcription factor complex binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0004519 endonuclease activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006312 mitotic recombination
GO:0006949 syncytium formation
GO:0006979 response to oxidative stress
GO:0007283 spermatogenesis
GO:0007584 response to nutrient
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0008584 male gonad development
GO:0009650 UV protection
GO:0009744 response to sucrose
GO:0010165 response to X-ray
GO:0010259 multicellular organism aging
GO:0019904 protein domain specific binding
GO:0032205 negative regulation of telomere maintenance
GO:0033683 nucleotide-excision repair, DNA incision
GO:0035166 post-embryonic hemopoiesis
GO:0035264 multicellular organism growth
GO:0035902 response to immobilization stress
GO:0036297 interstrand cross-link repair
GO:0045190 isotype switching
GO:0046686 response to cadmium ion
GO:0048477 oogenesis
GO:0048568 embryonic organ development
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0061819 telomeric DNA-containing double minutes formation
GO:0070522 ERCC4-ERCC1 complex
GO:0070911 global genome nucleotide-excision repair
GO:0070914 UV-damage excision repair
GO:0090399 replicative senescence
GO:0090656 t-circle formation
GO:1904431 positive regulation of t-circle formation
GO:1905765 negative regulation of protection from non-homologous end joining at telomere
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004579 ERCC1/RAD10/SWI10 familyFamilyFamily
IPR010994 RuvA domain 2-likeFamilyHomologous superfamily
IPR011335 Restriction endonuclease type II-likeFamilyHomologous superfamily

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
ERCC1_HUMANUBL7_HUMANBioGRID, HPRD, IntAct16189514 25416956 25910212 details
ERCC1_HUMANXPA_HUMANBioGRID, DIP, HPRD, IntAct11058119 16491090 17948053 18597777 19056823 24036546 25416956 26186194 28514442 32296183 7598728 8197174 9013642 9653453 details
ERCC1_HUMANSLX4_HUMANBioGRID, IntAct19595721 19596235 19596236 21240275 22902628 23033263 23093618 23623386 25538220 26186194 28514442 31495888 32398829 details
ERCC1_HUMANSLX1_HUMANBioGRID, IntAct19595721 19596235 28514442 details
ERCC1_HUMANMKRN3_HUMANBioGRID, IntAct25416956 details
ERCC1_HUMANUSBP1_HUMANBioGRID, IntAct25416956 details
ERCC1_HUMANTRM2_HUMANBioGRID, IntAct25416956 details
ERCC1_HUMANVP37B_HUMANBioGRID, IntAct25416956 31515488 details
ERCC1_HUMANXPF_HUMANBioGRID, DIP, HPRD, IntAct10413517 11160918 14706347 14734547 15932882 16076955 16338413 17289582 17912758 19940136 21466675 21875596 22353549 22939629 23580445 24036546 24780295 25538220 25956741 26085086 26186194 26344197 26453996 28514442 31495888 8197175 9013642 9722633 details
ERCC1_HUMANDRC4_HUMANBioGRID, IntAct32296183 details
ERCC1_HUMANACM5_HUMANBioGRID, MINT28298427 details
ERCC1_HUMANFANCG_HUMANBioGRID20518486 details
ERCC1_HUMANUHRF1_HUMANBioGRID25818288 details
ERCC1_HUMANA4_HUMANBioGRID21244100 details
ERCC1_HUMANUBP45_HUMANBioGRID25538220 30258100 details
ERCC1_HUMANRFA1_HUMANBioGRID24036546 details
ERCC1_HUMANRFA2_HUMANBioGRID24036546 details
ERCC1_HUMANRFA3_HUMANBioGRID24036546 details
ERCC1_HUMANKIF11_HUMANBioGRID22353549 details
ERCC1_HUMANRAD52_HUMANBioGRID14734547 details
ERCC1_HUMANEGFR_HUMANBioGRID, IntAct24780295 details
ERCC1_HUMANMUS81_HUMANBioGRID, IntAct25538220 28514442 details
ERCC1_HUMANSLX4I_HUMANBioGRID, IntAct26186194 28514442 31495888 details
ERCC1_HUMANCASS4_HUMANIntAct31413325 details
ERCC1_HUMANTF2H1_HUMANBioGRID11259578 details
ERCC1_HUMANTAF6_HUMANBioGRID22323595 details
ERCC1_HUMANTAF7_HUMANBioGRID22323595 details
ERCC1_HUMANTAF10_HUMANBioGRID22323595 details
ERCC1_HUMANTAF12_HUMANBioGRID22323595 details
ERCC1_HUMANTBP_HUMANBioGRID22323595 details
ERCC1_HUMANRPB1_HUMANBioGRID16916636 details
ERCC1_HUMANMSH2_HUMANBioGRID14706347 details
ERCC1_HUMANSPTA1_HUMANBioGRID16889989 details
ERCC1_HUMANERCC1_HUMANBioGRID28903417 details
ERCC1_HUMANMD2L1_HUMANBioGRID18597777 details
ERCC1_HUMANDCAF7_HUMANBioGRID31493872 details