Entity Details

Primary name ACM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08172
EntryNameACM2_HUMAN
FullNameMuscarinic acetylcholine receptor M2
TaxID9606
Evidenceevidence at protein level
Length466
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesCHRM2

GO terms

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GOName
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006940 regulation of smooth muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007399 nervous system development
GO:0008016 regulation of heart contraction
GO:0009615 response to virus
GO:0016021 integral component of membrane
GO:0016907 G protein-coupled acetylcholine receptor activity
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0061024 membrane organization
GO:1990763 arrestin family protein binding

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000995 Muscarinic acetylcholine receptor familyFamilyFamily
IPR001065 Muscarinic acetylcholine receptor M2FamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00202 SuccinylcholineDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00280 DisopyramideDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00332 IpratropiumDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00340 MetixeneDrugbanksmall molecule
DB00342 TerfenadineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00366 DoxylamineDrugbanksmall molecule
DB00376 TrihexyphenidylDrugbanksmall molecule
DB00383 OxyphencyclimineDrugbanksmall molecule
DB00387 ProcyclidineDrugbanksmall molecule
DB00392 ProfenamineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00411 CarbamoylcholineDrugbanksmall molecule
DB00424 HyoscyamineDrugbanksmall molecule
DB00434 CyproheptadineDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00462 Methscopolamine bromideDrugbanksmall molecule
DB00483 Gallamine triethiodideDrugbanksmall molecule
DB00496 DarifenacinDrugbanksmall molecule
DB00505 TridihexethylDrugbanksmall molecule
DB00508 TriflupromazineDrugbanksmall molecule
DB00517 Anisotropine methylbromideDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00572 AtropineDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00725 Homatropine methylbromideDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00728 RocuroniumDrugbanksmall molecule
DB00747 ScopolamineDrugbanksmall molecule
DB00767 BenzquinamideDrugbanksmall molecule
DB00777 PropiomazineDrugbanksmall molecule
DB00785 CryptenamineDrugbanksmall molecule
DB00804 DicyclomineDrugbanksmall molecule
DB00809 TropicamideDrugbanksmall molecule
DB00835 BrompheniramineDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00940 MethanthelineDrugbanksmall molecule
DB00986 GlycopyrroniumDrugbanksmall molecule
DB01019 BethanecholDrugbanksmall molecule
DB01036 TolterodineDrugbanksmall molecule
DB01062 OxybutyninDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01075 DiphenhydramineDrugbanksmall molecule
DB01085 PilocarpineDrugbanksmall molecule
DB01135 DoxacuriumDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01148 FlavoxateDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01226 MivacuriumDrugbanksmall molecule
DB01231 DiphenidolDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01336 MetocurineDrugbanksmall molecule
DB01337 PancuroniumDrugbanksmall molecule
DB01338 PipecuroniumDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01409 TiotropiumDrugbanksmall molecule
DB01591 SolifenacinDrugbanksmall molecule
DB03128 AcetylcholineDrugbanksmall molecule
DB04834 RapacuroniumDrugbanksmall molecule
DB05752 ALKS 27Drugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06702 FesoterodineDrugbanksmall molecule
DB06787 HexocycliumDrugbanksmall molecule
DB08801 DimetindeneDrugbanksmall molecule
DB08897 AclidiniumDrugbanksmall molecule
DB09076 UmeclidiniumDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09262 ImidafenacinDrugbanksmall molecule
DB09300 ButylscopolamineDrugbanksmall molecule
DB11181 HomatropineDrugbanksmall molecule
DB11235 ThonzylamineDrugbanksmall molecule
DB11855 RevefenacinDrugbanksmall molecule
DB12278 PropiverineDrugbanksmall molecule
DB13581 RociverineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule