Entity Details

Primary name ITA2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08514
EntryNameITA2B_HUMAN
FullNameIntegrin alpha-IIb
TaxID9606
Evidenceevidence at protein level
Length1039
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesITGA2B

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0002687 positive regulation of leukocyte migration
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0030198 extracellular matrix organization
GO:0031092 platelet alpha granule membrane
GO:0042802 identical protein binding
GO:0045652 regulation of megakaryocyte differentiation
GO:0046872 metal ion binding
GO:0050840 extracellular matrix binding
GO:0070051 fibrinogen binding
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00054 AbciximabDrugbankbiotech
DB00775 TirofibanDrugbanksmall molecule
DB04863 LefradafibanDrugbanksmall molecule
DB06472 FradafibanDrugbanksmall molecule