Entity Details

Primary name MET_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08581
EntryNameMET_HUMAN
FullNameHepatocyte growth factor receptor
TaxID9606
Evidenceevidence at protein level
Length1390
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesMET

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001886 endothelial cell morphogenesis
GO:0001889 liver development
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005008 hepatocyte growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006909 phagocytosis
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010507 negative regulation of autophagy
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0017154 semaphorin receptor activity
GO:0019903 protein phosphatase binding
GO:0030182 neuron differentiation
GO:0031016 pancreas development
GO:0031116 positive regulation of microtubule polymerization
GO:0033674 positive regulation of kinase activity
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035635 entry of bacterium into host cell
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050918 positive chemotaxis
GO:0051497 negative regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0061436 establishment of skin barrier
GO:0070495 negative regulation of thrombin-activated receptor signaling pathway
GO:0071526 semaphorin-plexin signaling pathway
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
GO:2001028 positive regulation of endothelial cell chemotaxis

Subcellular Location

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Subcellular Location
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001627 Sema domainDomainDomain
IPR002165 Plexin repeatRepeatRepeat
IPR002909 IPT domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR016201 PSI domainDomainDomain
IPR016244 Tyrosine-protein kinase, HGF/MSP receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR031148 Plexin familyFamilyFamily
IPR036352 Sema domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
114550 OMIMHepatocellular carcinoma (HCC)A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. The disease is caused by variants affecting the gene represented in this entry.
605074 OMIMRenal cell carcinoma papillary (RCCP)A subtype of renal cell carcinoma tending to show a tubulo-papillary architecture formed by numerous, irregular, finger-like projections of connective tissue. Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. The disease is caused by variants affecting the gene represented in this entry.
616705 OMIMDeafness, autosomal recessive, 97 (DFNB97)A form of non-syndromic sensorineural hearing loss with prelingual onset. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.
607278 OMIMOsteofibrous dysplasia (OSFD)A congenital disorder of osteogenesis characterized by non-neoplastic, radiolucent lesions that affect the cortical bone immediately under the periosteum. It usually manifests as a painless swelling or anterior bowing of the long bones, most commonly the tibia and fibula. Disease susceptibility is associated with variants affecting the gene represented in this entry. Disease-associated variants identified in 4 families cause the deletion of exon 14. This results in the exclusion of an ubiquitination target site within the cytoplasmic domain, hence in protein stabilization. The persistent presence of MET at the cell surface in conditions of ligand-dependent activation retards osteoblastic differentiation.

Drugs

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DrugNameSourceType
DB02152 K-252aDrugbanksmall molecule
DB06314 SGX-523Drugbanksmall molecule
DB06896 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamideDrugbanksmall molecule
DB06995 N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamideDrugbanksmall molecule
DB06997 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamideDrugbanksmall molecule
DB07369 N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamideDrugbanksmall molecule
DB07969 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenolDrugbanksmall molecule
DB08079 AMG-208Drugbanksmall molecule
DB08791 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDEDrugbanksmall molecule
DB08865 CrizotinibDrugbanksmall molecule
DB08875 CabozantinibDrugbanksmall molecule
DB11791 CapmatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12200 TivantinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB12742 AmuvatinibDrugbanksmall molecule

Interactions

147 interactions

InteractorPartnerSourcesPublicationsLink
MET_HUMANCBL_HUMANBioGRID, HPRD, IntAct, MINT11894096 15123609 16397241 18273061 19433454 19450681 21163258 21222362 25241761 details
MET_HUMANRANB9_HUMANBioGRID, HPRD, MINT12147692 details
MET_HUMANPLXB1_HUMANHPRD, IntAct, MINT, Molecular Connections12198496 15184888 22404908 details
MET_HUMANHGF_HUMANBioGRID, DIP, HPRD, IntAct15167892 16537482 1655405 17804794 17981115 1846706 18495663 18593464 19433454 20624990 22897854 28205554 8380735 details
MET_HUMANPTN1_HUMANIntAct, MINT16537444 18579758 22789536 details
MET_HUMANPTN11_HUMANBioGRID, HPRD, IntAct, MINT18579758 24728074 8662733 details
MET_HUMANPTPRC_HUMANIntAct19167335 details
MET_HUMANPTPRK_HUMANIntAct19167335 details
MET_HUMANPTPRG_HUMANIntAct19167335 details
MET_HUMANPTPRJ_HUMANHPRD, IntAct, MINT12370829 12475979 19167335 details
MET_HUMANPTPRO_HUMANBioGRID, IntAct19167335 28330616 details
MET_HUMANPTN3_HUMANIntAct19167335 details
MET_HUMANPTN12_HUMANIntAct19167335 details
MET_HUMANEGFR_HUMANBioGRID, DIP, HPRD, IntAct, Molecular Connections10722725 20624308 21918175 23866081 24189400 24362532 26551075 details
MET_HUMANSRC_HUMANBioGRID, HPRD, IntAct, Molecular Connections20624308 24034250 24728074 9837958 details
MET_HUMANPASK_HUMANMINT21418524 details
MET_HUMANDNJA3_HUMANHPRD, I2D15546961 21242965 details
MET_HUMANPTPRB_HUMANHPRD, MINT16101282 details
MET_HUMANCD44_HUMANBioGRID, IntAct22897854 28205554 details
MET_HUMANRASA1_HUMANBioGRID, IntAct24728074 details
MET_HUMANP85A_HUMANBioGRID, HPRD, IntAct24728074 7513258 details
MET_HUMANSOCS6_HUMANBioGRID, IntAct24728074 details
MET_HUMANSTAP1_HUMANBioGRID, IntAct24728074 details
MET_HUMANP55G_HUMANBioGRID, IntAct24728074 details
MET_HUMANLCK_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHC4_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH21B_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHD_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHC2_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH2D3_HUMANBioGRID, IntAct24728074 details
MET_HUMANP85B_HUMANBioGRID, IntAct24728074 details
MET_HUMANKSYK_HUMANBioGRID, IntAct24728074 details
MET_HUMANTENS3_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHC1_HUMANBioGRID, HPRD, IntAct24728074 7731718 9660480 details
MET_HUMANYES_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHB_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH22A_HUMANBioGRID, IntAct24728074 details
MET_HUMANSLAP2_HUMANBioGRID, IntAct24728074 details
MET_HUMANVAV3_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH21A_HUMANBioGRID, IntAct24728074 details
MET_HUMANPLCG1_HUMANBioGRID, HPRD, IntAct24728074 7513258 8662733 details
MET_HUMANNCK2_HUMANBioGRID, IntAct24728074 details
MET_HUMANNCK1_HUMANBioGRID, IntAct24728074 details
MET_HUMAN3BP2_HUMANBioGRID, IntAct24728074 details
MET_HUMANSOCS5_HUMANBioGRID, IntAct24728074 details
MET_HUMANSOCS3_HUMANBioGRID, IntAct24728074 details
MET_HUMANLYN_HUMANBioGRID, IntAct24728074 34079125 details
MET_HUMANTEC_HUMANBioGRID, IntAct24728074 details
MET_HUMANBLK_HUMANBioGRID, IntAct24728074 details
MET_HUMANZAP70_HUMANBioGRID, IntAct24728074 details
MET_HUMANTNS2_HUMANBioGRID, IntAct24728074 details
MET_HUMANPLCG2_HUMANBioGRID, IntAct24728074 details
MET_HUMANTENS1_HUMANBioGRID, IntAct24728074 details
MET_HUMANFGR_HUMANBioGRID, IntAct24728074 details
MET_HUMANITK_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHC3_HUMANBioGRID, IntAct24728074 details
MET_HUMANHCK_HUMANBioGRID, IntAct24728074 details
MET_HUMANPTK6_HUMANBioGRID, IntAct24728074 details
MET_HUMANTXK_HUMANBioGRID, IntAct24728074 details
MET_HUMANSOCS2_HUMANBioGRID, IntAct24728074 details
MET_HUMANGRB7_HUMANBioGRID, IntAct24728074 details
MET_HUMANABL2_HUMANBioGRID, IntAct24728074 details
MET_HUMANMATK_HUMANBioGRID, IntAct24728074 details
MET_HUMANSOCS1_HUMANBioGRID, IntAct24728074 25728680 details
MET_HUMANGRB14_HUMANBioGRID, IntAct24728074 details
MET_HUMANHSH2D_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH2B1_HUMANBioGRID, IntAct24728074 details
MET_HUMANBTK_HUMANBioGRID, IntAct24728074 details
MET_HUMANSHIP2_HUMANBioGRID, HPRD, IntAct15735664 19713535 24728074 details
MET_HUMANVAV2_HUMANBioGRID, IntAct24728074 details
MET_HUMANFES_HUMANBioGRID, IntAct24728074 details
MET_HUMANTENS4_HUMANBioGRID, IntAct24728074 details
MET_HUMANCRK_HUMANBioGRID, IntAct24728074 24828152 details
MET_HUMANSH2B3_HUMANBioGRID, IntAct24728074 details
MET_HUMANBCAR3_HUMANBioGRID, IntAct24728074 details
MET_HUMANSH2B2_HUMANBioGRID, IntAct24728074 details
MET_HUMANSCRIB_HUMANMINT24550280 details
MET_HUMANMET_HUMANBioGRID, DIP, HPRD16537482 1655405 1655790 17192257 20624990 23794705 26285778 details
MET_HUMANMNDA_HUMANIntAct32814053 details
MET_HUMANGRB2_HUMANBioGRID, HPRD, IntAct11063574 11439336 15546961 19433454 21222362 7511210 8662889 9660480 details
MET_HUMANGLMN_HUMANBioGRID, HPRD11571281 details
MET_HUMANRBP10_HUMANBioGRID, HPRD14684163 details
MET_HUMANPGS2_HUMANBioGRID19433454 details
MET_HUMANITB1_HUMANBioGRID28973887 details
MET_HUMANERBB2_HUMANBioGRID30898150 details
MET_HUMANGLIS2_HUMANBioGRID28205554 details
MET_HUMANMP2K5_HUMANBioGRID28205554 details
MET_HUMANCCND2_HUMANBioGRID28205554 details
MET_HUMANEPHA2_HUMANBioGRID28205554 details
MET_HUMANFGFR4_HUMANBioGRID28205554 details
MET_HUMANSTK11_HUMANBioGRID28205554 details
MET_HUMANFZR1_HUMANBioGRID28205554 details
MET_HUMANERD22_HUMANBioGRID28205554 details
MET_HUMANMP2K3_HUMANBioGRID28205554 details
MET_HUMANCDK4_HUMANBioGRID28205554 details
MET_HUMANCDK6_HUMANBioGRID28205554 details
MET_HUMANCDN2B_HUMANBioGRID28205554 details
MET_HUMANLATS2_HUMANBioGRID28205554 details
MET_HUMANTERT_HUMANBioGRID28205554 details
MET_HUMANMYC_HUMANBioGRID28205554 details
MET_HUMANMERL_HUMANBioGRID28205554 details
MET_HUMANRAF1_HUMANBioGRID28205554 details
MET_HUMANRASF1_HUMANBioGRID28205554 details
MET_HUMANP53_HUMANBioGRID28205554 details
MET_HUMANSNAPN_HUMANHPRD15546961 details
MET_HUMANPHS2_HUMANHPRD15546961 details
MET_HUMANVAV_HUMANHPRD15546961 details
MET_HUMANSNX2_HUMANHPRD15546961 details
MET_HUMANDAPK3_HUMANHPRD15546961 details
MET_HUMANSMC1A_HUMANHPRD15546961 details
MET_HUMANSHIP1_HUMANHPRD15735664 details
MET_HUMANMUC20_HUMANHPRD15314156 details
MET_HUMANGAB1_HUMANBioGRID, HPRD, MINT10734310 10871282 10913131 10995442 9242692 details
MET_HUMAN1433Z_HUMANIntAct17353931 details
MET_HUMANPLXB2_HUMANIntAct15184888 details
MET_HUMANPLXB3_HUMANIntAct15184888 details
MET_HUMANVGFR2_HUMANIntAct22789536 details
MET_HUMANCASP3_HUMANBioGRID, HPRD, IntAct15542841 25241761 details
MET_HUMANMUC1_HUMANMolecular Connections22962849 details
MET_HUMANLAP4B_HUMANIntAct25594178 details
MET_HUMANERBB3_HUMANBioGRID, DIP21918175 25326665 details
MET_HUMANLRIG1_HUMANBioGRID, IntAct17178829 24828152 details
MET_HUMANCADH1_HUMANBioGRID11254878 details
MET_HUMANCTNB1_HUMANBioGRID, HPRD11254878 11929826 details
MET_HUMANSH3K1_HUMANBioGRID11894096 details
MET_HUMANSOS1_HUMANBioGRID9660480 details
MET_HUMANSTAT3_HUMANBioGRID, HPRD9440692 details
MET_HUMANGAB2_HUMANBioGRID10871282 details
MET_HUMANSPSB1_HUMANBioGRID, HPRD15713673 details
MET_HUMANSPSB2_HUMANBioGRID15713673 details
MET_HUMANSPSB3_HUMANBioGRID15713673 details
MET_HUMANSPSB4_HUMANBioGRID15713673 details
MET_HUMANCBLC_HUMANBioGRID22888118 details
MET_HUMANCHIP_HUMANBioGRID21325980 details
MET_HUMANHSP74_HUMANBioGRID21325980 details
MET_HUMANHS90A_HUMANBioGRID21325980 26517842 details
MET_HUMANGGA3_HUMANBioGRID21664574 details
MET_HUMANHGS_HUMANBioGRID, HPRD24828152 8380735 details
MET_HUMANHS90B_HUMANBioGRID26517842 details
MET_HUMAN1433S_HUMANBioGRID29880877 details
MET_HUMANITAV_HUMANBioGRID28973887 details
MET_HUMANGSK3B_HUMANBioGRID30711629 details
MET_HUMANCNR1_HUMANHPRD11894096 details
MET_HUMANTNR6_HUMANHPRD15911745 details
MET_HUMANITB4_HUMANHPRD11733063 14602071 details
MET_HUMANSRC8_HUMANHPRD11439336 details
MET_HUMANBAG1_HUMANHPRD8947043 details