Entity Details

Primary name GSTP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09211
EntryNameGSTP1_HUMAN
FullNameGlutathione S-transferase P
TaxID9606
Evidenceevidence at protein level
Length210
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesGSTP1

GO terms

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GOName
GO:0000302 response to reactive oxygen species
GO:0002674 negative regulation of acute inflammatory response
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0005504 fatty acid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006469 negative regulation of protein kinase activity
GO:0006693 prostaglandin metabolic process
GO:0006749 glutathione metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007417 central nervous system development
GO:0008432 JUN kinase binding
GO:0009890 negative regulation of biosynthetic process
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0014003 oligodendrocyte development
GO:0019207 kinase regulator activity
GO:0031100 animal organ regeneration
GO:0031982 vesicle
GO:0032355 response to estradiol
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032869 cellular response to insulin stimulus
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0032930 positive regulation of superoxide anion generation
GO:0033591 response to L-ascorbic acid
GO:0034599 cellular response to oxidative stress
GO:0034774 secretory granule lumen
GO:0035726 common myeloid progenitor cell proliferation
GO:0035730 S-nitrosoglutathione binding
GO:0035731 dinitrosyl-iron complex binding
GO:0035732 nitric oxide storage
GO:0043066 negative regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200 response to amino acid
GO:0043312 neutrophil degranulation
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043508 negative regulation of JUN kinase activity
GO:0043651 linoleic acid metabolic process
GO:0045471 response to ethanol
GO:0048147 negative regulation of fibroblast proliferation
GO:0051122 hepoxilin biosynthetic process
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
GO:0070026 nitric oxide binding
GO:0070062 extracellular exosome
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070664 negative regulation of leukocyte proliferation
GO:0071222 cellular response to lipopolysaccharide
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071460 cellular response to cell-matrix adhesion
GO:0071638 negative regulation of monocyte chemotactic protein-1 production
GO:0071672 negative regulation of smooth muscle cell chemotaxis
GO:0097057 TRAF2-GSTP1 complex
GO:1901687 glutathione derivative biosynthetic process
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1904813 ficolin-1-rich granule lumen
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR003082 Glutathione S-transferase, Pi classFamilyFamily
IPR004045 Glutathione S-transferase, N-terminalDomainDomain
IPR004046 Glutathione S-transferase, C-terminalDomainDomain
IPR010987 Glutathione S-transferase, C-terminal-likeDomainDomain
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR040079 Glutathione Transferase familyFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00163 Vitamin EDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00291 ChlorambucilSwissprotsmall molecule
DB00316 AcetaminophenDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00903 Etacrynic acidDrugbanksmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB01008 BusulfanSwissprotsmall molecule
DB01242 ClomipramineDrugbanksmall molecule
DB01834 (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthreneDrugbanksmall molecule
DB01915 S-HydroxycysteineDrugbanksmall molecule
DB02633 Cibacron BlueDrugbanksmall molecule
DB03003 Glutathione sulfonic acidDrugbanksmall molecule
DB03310 Glutathione disulfideDrugbanksmall molecule
DB03619 Deoxycholic acidDrugbanksmall molecule
DB03686 S-(4-nitrobenzyl)glutathioneDrugbanksmall molecule
DB03814 2-(N-morpholino)ethanesulfonic acidDrugbanksmall molecule
DB04132 S-HexylglutathioneDrugbanksmall molecule
DB04339 CarbocisteineDrugbanksmall molecule
DB04972 CanfosfamideDrugbanksmall molecule
DB05460 EzatiostatDrugbanksmall molecule
DB06246 ExisulindDrugbanksmall molecule
DB07849 S-NONYL-CYSTEINEDrugbanksmall molecule
DB08370 S-(4-BROMOBENZYL)CYSTEINEDrugbanksmall molecule
DB11672 CurcuminDrugbanksmall molecule
DB11831 DinitrochlorobenzeneDrugbanksmall molecule
DB13014 HypericinDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule
DB14635 Curcumin sulfateDrugbanksmall molecule

Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
GSTP1_HUMANPTN_HUMANBioGRID, HPRD, IntAct16169070 details
GSTP1_HUMANPNO1_HUMANBioGRID, HPRD, IntAct16169070 details
GSTP1_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct16636664 24457959 25241761 details
GSTP1_HUMANMLH1_HUMANBioGRID, IntAct20706999 details
GSTP1_HUMANSFR19_HUMANBioGRID, IntAct21988832 details
GSTP1_HUMANSHLB1_HUMANBioGRID, IntAct23414517 details
GSTP1_HUMANMK08_HUMANBioGRID, HPRD, IntAct11279197 12646564 16636664 25241761 26429914 details
GSTP1_HUMANPRDX6_HUMANBioGRID, IntAct16401067 23164639 31536960 details
GSTP1_HUMANKR107_HUMANBioGRID, IntAct25416956 32296183 details
GSTP1_HUMANKR109_HUMANBioGRID, IntAct25416956 details
GSTP1_HUMANK1H1_HUMANBioGRID, IntAct25416956 32296183 details
GSTP1_HUMANNT2NA_HUMANBioGRID, IntAct25416956 32296183 details
GSTP1_HUMANAPBP2_HUMANBioGRID, IntAct25416956 32296183 details
GSTP1_HUMANCAR10_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANMTUS2_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANFHL5_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANLR2BP_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANZN655_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANTGM1_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANATL4_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANNT2NC_HUMANBioGRID, IntAct25416956 32296183 details
GSTP1_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANKRA31_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANKRA33_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANKRT83_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANKT33B_HUMANBioGRID, IntAct32296183 details
GSTP1_HUMANFANCC_HUMANBioGRID, HPRD11433346 14499622 details
GSTP1_HUMANGSTP1_HUMANBioGRID, HPRD16401067 9398518 details
GSTP1_HUMANKR103_HUMANBioGRID25416956 details
GSTP1_HUMANEGFR_HUMANBioGRID19254954 26429914 details
GSTP1_HUMANKRA13_HUMANBioGRID32296183 details
GSTP1_HUMANOGT1_HUMANBioGRID32994395 details
GSTP1_HUMANM3K5_HUMANIntAct16636664 details
GSTP1_HUMANMK14_HUMANIntAct16636664 details
GSTP1_HUMANMDM2_HUMANIntAct20195357 details
GSTP1_HUMANEPHA1_HUMANIntAct31413325 details
GSTP1_HUMANTGM2_HUMANBioGRID, HPRD9973324 details
GSTP1_HUMANMK01_HUMANBioGRID16636664 details
GSTP1_HUMANM3K1_HUMANBioGRID16636664 details
GSTP1_HUMANFXL12_HUMANBioGRID26124079 details
GSTP1_HUMANSUMO4_HUMANHPRD16236267 details