Entity Details

Primary name CD3G_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09693
EntryNameCD3G_HUMAN
FullNameT-cell surface glycoprotein CD3 gamma chain
TaxID9606
Evidenceevidence at protein level
Length182
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCD3G

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004888 transmembrane signaling receptor activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007163 establishment or maintenance of cell polarity
GO:0007166 cell surface receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0015031 protein transport
GO:0018149 peptide cross-linking
GO:0030159 signaling receptor complex adaptor activity
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042101 T cell receptor complex
GO:0042105 alpha-beta T cell receptor complex
GO:0042110 T cell activation
GO:0042608 T cell receptor binding
GO:0042802 identical protein binding
GO:0045059 positive thymic T cell selection
GO:0046982 protein heterodimerization activity
GO:0050776 regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:0061024 membrane organization
GO:0065003 protein-containing complex assembly
GO:0070228 regulation of lymphocyte apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003110 Phosphorylated immunoreceptor signalling ITAMRepeatRepeat
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015484 CD3 protein, epsilon/gamma/delta subunitFamilyFamily
IPR032052 CD3 gamma/delta subunit, Ig-like domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615607 OMIMImmunodeficiency 17 (IMD17)An autosomal recessive primary immunodeficiency characterized by highly variable clinical severity. Some patients have onset of severe recurrent infections in early infancy that may be lethal, whereas others may be only mildly affected or essentially asymptomatic into young adulthood. More severely affected patients may have evidence of autoimmune disease or enteropathy. The immunologic pattern is similar among patients, showing partial T-cell lymphopenia, decreased amounts of the CD3 complex, and impaired proliferative responses to T-cell receptor dependent stimuli. The phenotype in some patients is reminiscent of severe combined immunodeficiency. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00075 MuromonabDrugbankbiotech