Entity Details

Primary name BMP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12643
EntryNameBMP2_HUMAN
FullNameBone morphogenetic protein 2
TaxID9606
Evidenceevidence at protein level
Length396
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesBMP2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000187 obsolete activation of MAPK activity
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001837 epithelial to mesenchymal transition
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002062 chondrocyte differentiation
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003176 aortic valve development
GO:0003181 atrioventricular valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003210 cardiac atrium formation
GO:0003272 endocardial cushion formation
GO:0003308 negative regulation of Wnt signaling pathway involved in heart development
GO:0003331 positive regulation of extracellular matrix constituent secretion
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006029 proteoglycan metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007219 Notch signaling pathway
GO:0007267 cell-cell signaling
GO:0007507 heart development
GO:0008083 growth factor activity
GO:0008285 negative regulation of cell population proliferation
GO:0009617 response to bacterium
GO:0009887 animal organ morphogenesis
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010894 negative regulation of steroid biosynthetic process
GO:0010922 positive regulation of phosphatase activity
GO:0019211 phosphatase activator activity
GO:0021537 telencephalon development
GO:0021978 telencephalon regionalization
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030282 bone mineralization
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031648 protein destabilization
GO:0032092 positive regulation of protein binding
GO:0032348 negative regulation of aldosterone biosynthetic process
GO:0033690 positive regulation of osteoblast proliferation
GO:0035051 cardiocyte differentiation
GO:0035054 embryonic heart tube anterior/posterior pattern specification
GO:0035630 bone mineralization involved in bone maturation
GO:0038098 sequestering of BMP from receptor via BMP binding
GO:0039706 co-receptor binding
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042482 positive regulation of odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0043065 positive regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043410 positive regulation of MAPK cascade
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045165 cell fate commitment
GO:0045600 positive regulation of fat cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0048711 positive regulation of astrocyte differentiation
GO:0048762 mesenchymal cell differentiation
GO:0048839 inner ear development
GO:0051042 negative regulation of calcium-independent cell-cell adhesion
GO:0055007 cardiac muscle cell differentiation
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060039 pericardium development
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060485 mesenchyme development
GO:0060804 positive regulation of Wnt signaling pathway by BMP signaling pathway
GO:0061036 positive regulation of cartilage development
GO:0061312 BMP signaling pathway involved in heart development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070700 BMP receptor binding
GO:0070724 BMP receptor complex
GO:0071407 cellular response to organic cyclic compound
GO:0071773 cellular response to BMP stimulus
GO:0072138 mesenchymal cell proliferation involved in ureteric bud development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900745 positive regulation of p38MAPK cascade
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1905072 cardiac jelly development
GO:1905222 atrioventricular canal morphogenesis
GO:2000065 negative regulation of cortisol biosynthetic process
GO:2000726 negative regulation of cardiac muscle cell differentiation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
BMP2_HUMANBMR1A_HUMANBioGRID, DIP, HPRD, IntAct, MINT10692589 10712517 10880444 10881198 11263668 15064755 16672363 18070108 19804412 20860622 21054789 25938661 details
BMP2_HUMANNOGG_HUMANHPRD, MINT10657699 15064755 19804412 details
BMP2_HUMANBMR1B_HUMANBioGRID, HPRD, MINT10712517 15064755 18070108 19229295 7811286 9872992 details
BMP2_HUMANFSTL1_HUMANMINT20860622 details
BMP2_HUMANDIP2A_HUMANMINT20860622 details
BMP2_HUMANWFKN1_HUMANMINT21054789 details
BMP2_HUMANWFKN2_HUMANMINT21054789 details
BMP2_HUMANBMP2_HUMANHPRD, MINT10074410 10692589 10881198 23122408 details
BMP2_HUMANRGMC_HUMANbhf-ucl, DIP18335997 25938661 details
BMP2_HUMANRGMA_HUMANDIP25938661 details
BMP2_HUMANRGMB_HUMANBioGRID, DIP15671031 25938661 details
BMP2_HUMANBMPR2_HUMANBioGRID, DIP, HPRD10712517 10880444 25938661 7791754 details
BMP2_HUMANAVR2A_HUMANBioGRID, DIP18070108 25938661 details
BMP2_HUMANCO2A1_HUMANBioGRID, HPRD10085302 details
BMP2_HUMANARP2_HUMANBioGRID10880444 details
BMP2_HUMANTGFB2_HUMANBioGRID, HPRD, IntAct25241761 9493905 details
BMP2_HUMANSOSD1_HUMANBioGRID, HPRD14623234 15020244 details
BMP2_HUMANEGLN_HUMANBioGRID, HPRD9872992 details
BMP2_HUMANMGP_HUMANBioGRID, HPRD11741887 details
BMP2_HUMANACVR1_HUMANHPRD8006002 details
BMP2_HUMANTGFB1_HUMANHPRD11456401 details
BMP2_HUMANCRDL2_HUMANHPRD14660436 details
BMP2_HUMANBMPER_HUMANHPRD12897139 details
BMP2_HUMANGREM2_HUMANHPRD15039429 details
BMP2_HUMANASCL1_HUMANHPRD9197246 details
BMP2_HUMANCHRD_HUMANHPRD15064755 details
BMP2_HUMANGREM1_HUMANHPRD15064755 details
BMP2_HUMANAVR2B_HUMANHPRD15064755 details