Entity Details

Primary name VATB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP15313
EntryNameVATB1_HUMAN
FullNameV-type proton ATPase subunit B, kidney isoform
TaxID9606
Evidenceevidence at protein level
Length513
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesATP6V1B1

GO terms

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GOName
GO:0001503 ossification
GO:0003091 renal water homeostasis
GO:0003096 renal sodium ion transport
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005902 microvillus
GO:0006693 prostaglandin metabolic process
GO:0006885 regulation of pH
GO:0007588 excretion
GO:0007605 sensory perception of sound
GO:0008286 insulin receptor signaling pathway
GO:0010468 regulation of gene expression
GO:0015078 proton transmembrane transporter activity
GO:0016241 regulation of macroautophagy
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0016787 hydrolase activity
GO:0030534 adult behavior
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0033572 transferrin transport
GO:0034198 cellular response to amino acid starvation
GO:0034220 ion transmembrane transport
GO:0035812 renal sodium excretion
GO:0042048 olfactory behavior
GO:0042472 inner ear morphogenesis
GO:0044877 protein-containing complex binding
GO:0045851 pH reduction
GO:0046034 ATP metabolic process
GO:0055064 chloride ion homeostasis
GO:0055074 calcium ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0070062 extracellular exosome
GO:0090383 phagosome acidification
GO:0098850 extrinsic component of synaptic vesicle membrane
GO:1902600 proton transmembrane transport

Subcellular Location

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Subcellular Location
Apical cell membrane
Basolateral cell membrane

Domains

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DomainNameCategoryType
IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainDomainDomain
IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domainDomainDomain
IPR005723 ATPase, V1 complex, subunit BFamilyFamily
IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active siteSiteActive site
IPR022879 V-type ATP synthase regulatory subunit B/betaFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
267300 OMIMRenal tubular acidosis, distal, with progressive nerve deafness (dRTA-D)An autosomal recessive disease characterized by the association of renal distal tubular acidosis with sensorineural hearing loss. Distal renal tubular acidosis is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. It is due to functional failure of alpha-intercalated cells of the cortical collecting duct of the distal nephron, where vectorial proton transport is required for urinary acidification. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01133 Tiludronic acidDrugbanksmall molecule

Interactions

76 interactions

InteractorPartnerSourcesPublicationsLink
VATB1_HUMANSUV91_HUMANBioGRID, MINT23455924 details
VATB1_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
VATB1_HUMANHSPB1_HUMANIntAct32814053 details
VATB1_HUMANTTHY_HUMANIntAct32814053 details
VATB1_HUMANWFS1_HUMANIntAct32814053 details
VATB1_HUMANIDLC_HUMANIntAct32814053 details
VATB1_HUMANBAG6_HUMANIntAct32814053 details
VATB1_HUMANKLF11_HUMANIntAct32814053 details
VATB1_HUMANDNJB6_HUMANIntAct32814053 details
VATB1_HUMANKIF1B_HUMANIntAct32814053 details
VATB1_HUMANRNF11_HUMANIntAct32814053 details
VATB1_HUMANATX1_HUMANIntAct32814053 details
VATB1_HUMANTADBP_HUMANIntAct32814053 details
VATB1_HUMANSTX1A_HUMANBioGRID12651853 details
VATB1_HUMANVPP1_HUMANBioGRID, IntAct20541250 21674799 22939629 26186194 28514442 details
VATB1_HUMANVATD_HUMANBioGRID, IntAct21674799 22939629 26186194 28514442 details
VATB1_HUMANVATA_HUMANBioGRID, IntAct21674799 26186194 28514442 details
VATB1_HUMANVATE1_HUMANBioGRID, IntAct21674799 22939629 26186194 28514442 details
VATB1_HUMANVATC1_HUMANBioGRID, IntAct21674799 26186194 28514442 details
VATB1_HUMANVATB2_HUMANBioGRID, IntAct21674799 22939629 26186194 28514442 details
VATB1_HUMANVATG1_HUMANBioGRID, IntAct21674799 26186194 28514442 details
VATB1_HUMANARL8B_HUMANBioGRID21674799 details
VATB1_HUMANVA0D1_HUMANBioGRID21674799 26186194 details
VATB1_HUMANVATH_HUMANBioGRID21674799 details
VATB1_HUMANBAF_HUMANBioGRID21674799 details
VATB1_HUMANLTOR1_HUMANBioGRID21674799 22939629 details
VATB1_HUMANS35F6_HUMANBioGRID21674799 details
VATB1_HUMANCD63_HUMANBioGRID21674799 details
VATB1_HUMANCD9_HUMANBioGRID21674799 details
VATB1_HUMANCHM1A_HUMANBioGRID21674799 details
VATB1_HUMANCHM1B_HUMANBioGRID21674799 details
VATB1_HUMANCHM2B_HUMANBioGRID21674799 details
VATB1_HUMANCHM4B_HUMANBioGRID21674799 details
VATB1_HUMANCHMP5_HUMANBioGRID21674799 details
VATB1_HUMANCATD_HUMANBioGRID21674799 details
VATB1_HUMANDJC13_HUMANBioGRID21674799 details
VATB1_HUMANDNJC5_HUMANBioGRID21674799 details
VATB1_HUMANMYOF_HUMANBioGRID21674799 details
VATB1_HUMANFLOT1_HUMANBioGRID21674799 details
VATB1_HUMANFLOT2_HUMANBioGRID21674799 details
VATB1_HUMANFRIH_HUMANBioGRID21674799 details
VATB1_HUMANGLCM_HUMANBioGRID21674799 details
VATB1_HUMANGGH_HUMANBioGRID21674799 details
VATB1_HUMANGBB1_HUMANBioGRID21674799 details
VATB1_HUMANIST1_HUMANBioGRID21674799 details
VATB1_HUMANLAMP1_HUMANBioGRID21674799 details
VATB1_HUMANLAMP2_HUMANBioGRID21674799 details
VATB1_HUMANMITD1_HUMANBioGRID21674799 details
VATB1_HUMANMYO1B_HUMANBioGRID21674799 details
VATB1_HUMANMYO1D_HUMANBioGRID21674799 details
VATB1_HUMANMYO3B_HUMANBioGRID21674799 details
VATB1_HUMANNICA_HUMANBioGRID21674799 details
VATB1_HUMANPKP4_HUMANBioGRID21674799 details
VATB1_HUMANPLBL1_HUMANBioGRID21674799 details
VATB1_HUMANRB22A_HUMANBioGRID21674799 details
VATB1_HUMANRAB35_HUMANBioGRID21674799 34079125 details
VATB1_HUMANRALB_HUMANBioGRID21674799 details
VATB1_HUMANRRAS_HUMANBioGRID21674799 details
VATB1_HUMANS10AB_HUMANBioGRID21674799 details
VATB1_HUMANSCRB2_HUMANBioGRID21674799 details
VATB1_HUMANAACT_HUMANBioGRID21674799 details
VATB1_HUMANSTOM_HUMANBioGRID21674799 details
VATB1_HUMANSTX12_HUMANBioGRID21674799 details
VATB1_HUMANSTX8_HUMANBioGRID21674799 details
VATB1_HUMANTACD2_HUMANBioGRID21674799 details
VATB1_HUMANTFR1_HUMANBioGRID21674799 details
VATB1_HUMANTM9S1_HUMANBioGRID21674799 details
VATB1_HUMANTM192_HUMANBioGRID21674799 details
VATB1_HUMANTMOD3_HUMANBioGRID21674799 details
VATB1_HUMANVAMP7_HUMANBioGRID21674799 details
VATB1_HUMANVAMP8_HUMANBioGRID21674799 details
VATB1_HUMANCHMP3_HUMANBioGRID21674799 details
VATB1_HUMANVTI1B_HUMANBioGRID21674799 details
VATB1_HUMANVPP4_HUMANBioGRID27127844 details
VATB1_HUMANACTN4_HUMANHPRD10915794 details
VATB1_HUMANNHRF1_HUMANHPRD10748165 details