Entity Details

Primary name IL7RA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16871
EntryNameIL7RA_HUMAN
FullNameInterleukin-7 receptor subunit alpha
TaxID9606
Evidenceevidence at protein level
Length459
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesIL7R

GO terms

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GOName
GO:0000018 regulation of DNA recombination
GO:0000902 cell morphogenesis
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0003823 antigen binding
GO:0004896 cytokine receptor activity
GO:0004917 interleukin-7 receptor activity
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0008361 regulation of cell size
GO:0009897 external side of plasma membrane
GO:0010628 positive regulation of gene expression
GO:0016021 integral component of membrane
GO:0030217 T cell differentiation
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0038111 interleukin-7-mediated signaling pathway
GO:0042100 B cell proliferation
GO:0048535 lymph node development
GO:0048872 homeostasis of number of cells
GO:0050830 defense response to Gram-positive bacterium
GO:0061024 membrane organization
GO:0070233 negative regulation of T cell apoptotic process
GO:1904894 positive regulation of receptor signaling pathway via STAT

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003531 Short hematopoietin receptor, family 1, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR040997 IL-7Ralpha, fibronectin type III domainDomainDomain

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
IL7RA_HUMANIL7_HUMANDIP, HPRD, UniProt10390077 11858939 19141282 8266077 details
IL7RA_HUMANVAMP5_HUMANIntAct32296183 details
IL7RA_HUMANFAM3C_HUMANIntAct32296183 details
IL7RA_HUMANCD302_HUMANIntAct32296183 details
IL7RA_HUMANTMM60_HUMANIntAct32296183 details
IL7RA_HUMANVATL_HUMANIntAct32296183 details
IL7RA_HUMANT120B_HUMANBioGRID, IntAct32296183 details
IL7RA_HUMANMALL_HUMANBioGRID, IntAct32296183 details
IL7RA_HUMANATRAP_HUMANBioGRID, IntAct32296183 details
IL7RA_HUMANCD20_HUMANBioGRID, IntAct32296183 details
IL7RA_HUMANAPOL3_HUMANBioGRID, IntAct32296183 details
IL7RA_HUMANSDC4_HUMANBioGRID, IntAct32296183 details
IL7RA_HUMANBRI3_HUMANIntAct30983867 details
IL7RA_HUMANRAD21_HUMANBioGRID22145905 details
IL7RA_HUMANKIT_HUMANBioGRID17554063 details
IL7RA_HUMANIL2RG_HUMANHPRD, IntAct23726671 8266077 details
IL7RA_HUMANFAK2_HUMANBioGRID, HPRD10702271 details
IL7RA_HUMANFYN_HUMANBioGRID, HPRD7515933 details
IL7RA_HUMANCBL_HUMANBioGRID20404156 details
IL7RA_HUMANJAK3_HUMANBioGRID, HPRD15996891 17554063 7481769 details
IL7RA_HUMANCISH_HUMANBioGRID27423467 27596538 details
IL7RA_HUMANSOCS1_HUMANBioGRID27423467 details
IL7RA_HUMANSOCS2_HUMANBioGRID27423467 details
IL7RA_HUMANP85A_HUMANBioGRID, HPRD7522165 details
IL7RA_HUMANSTA5A_HUMANHPRD7719938 details
IL7RA_HUMANSTA5B_HUMANHPRD7719938 details
IL7RA_HUMANSTAT3_HUMANHPRD7719938 details
IL7RA_HUMANJAK1_HUMANHPRD15996891 8647212 details
IL7RA_HUMANLYN_HUMANHPRD7515933 details
IL7RA_HUMANCRLF2_HUMANHPRD11418668 details
IL7RA_HUMANTSLP_HUMANHPRD11418668 details