Entity Details

Primary name AATC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17174
EntryNameAATC_HUMAN
FullNameAspartate aminotransferase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length413
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesGOT1

GO terms

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GOName
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004609 phosphatidylserine decarboxylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0006094 gluconeogenesis
GO:0006103 2-oxoglutarate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006114 glycerol biosynthetic process
GO:0006531 aspartate metabolic process
GO:0006532 aspartate biosynthetic process
GO:0006533 aspartate catabolic process
GO:0006536 glutamate metabolic process
GO:0007219 Notch signaling pathway
GO:0009066 aspartate family amino acid metabolic process
GO:0009743 response to carbohydrate
GO:0019550 glutamate catabolic process to aspartate
GO:0019551 glutamate catabolic process to 2-oxoglutarate
GO:0030170 pyridoxal phosphate binding
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031406 carboxylic acid binding
GO:0032869 cellular response to insulin stimulus
GO:0032966 negative regulation of collagen biosynthetic process
GO:0035902 response to immobilization stress
GO:0043679 axon terminus
GO:0046686 response to cadmium ion
GO:0047801 L-cysteine:2-oxoglutarate aminotransferase activity
GO:0051384 response to glucocorticoid
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051902 negative regulation of mitochondrial depolarization
GO:0055089 fatty acid homeostasis
GO:0060290 transdifferentiation
GO:0070062 extracellular exosome
GO:0071260 cellular response to mechanical stimulus
GO:1990267 response to transition metal nanoparticle

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000796 Aspartate/other aminotransferaseFamilyFamily
IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding siteSiteBinding site
IPR004839 Aminotransferase, class I/classIIDomainDomain
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00128 Aspartic acidDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule
DB00151 CysteineDrugbanksmall molecule
DB00210 AdapaleneDrugbanksmall molecule
DB04299 Maleic AcidDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule