Entity Details

Primary name CXA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17302
EntryNameCXA1_HUMAN
FullNameGap junction alpha-1 protein
TaxID9606
Evidenceevidence at protein level
Length382
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesGJA1

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0000139 Golgi membrane
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002544 chronic inflammatory response
GO:0002931 response to ischemia
GO:0003104 positive regulation of glomerular filtration
GO:0003158 endothelium development
GO:0003161 cardiac conduction system development
GO:0005243 gap junction channel activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005771 multivesicular body
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005916 fascia adherens
GO:0005921 gap junction
GO:0005922 connexin complex
GO:0005925 focal adhesion
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007283 spermatogenesis
GO:0008013 beta-catenin binding
GO:0009268 response to pH
GO:0009749 response to glucose
GO:0010232 vascular transport
GO:0010628 positive regulation of gene expression
GO:0010644 cell communication by electrical coupling
GO:0010649 regulation of cell communication by electrical coupling
GO:0010652 positive regulation of cell communication by chemical coupling
GO:0014047 glutamate secretion
GO:0014704 intercalated disc
GO:0015075 ion transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0015631 tubulin binding
GO:0015867 ATP transport
GO:0016264 gap junction assembly
GO:0016324 apical plasma membrane
GO:0017124 SH3 domain binding
GO:0022898 regulation of transmembrane transporter activity
GO:0030054 cell junction
GO:0030165 PDZ domain binding
GO:0030308 negative regulation of cell growth
GO:0030660 Golgi-associated vesicle membrane
GO:0032024 positive regulation of insulin secretion
GO:0032277 negative regulation of gonadotropin secretion
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032526 response to retinoic acid
GO:0034220 ion transmembrane transport
GO:0034405 response to fluid shear stress
GO:0034613 cellular protein localization
GO:0034634 glutathione transmembrane transporter activity
GO:0035437 maintenance of protein localization in endoplasmic reticulum
GO:0035633 maintenance of blood-brain barrier
GO:0042908 xenobiotic transport
GO:0042981 regulation of apoptotic process
GO:0043014 alpha-tubulin binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0043434 response to peptide hormone
GO:0044291 cell-cell contact zone
GO:0045121 membrane raft
GO:0045732 positive regulation of protein catabolic process
GO:0045907 positive regulation of vasoconstriction
GO:0046697 decidualization
GO:0046849 bone remodeling
GO:0048812 neuron projection morphogenesis
GO:0051924 regulation of calcium ion transport
GO:0055077 gap junction hemi-channel activity
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060348 bone development
GO:0061045 negative regulation of wound healing
GO:0070160 tight junction
GO:0071253 connexin binding
GO:0071260 cellular response to mechanical stimulus
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0086014 atrial cardiac muscle cell action potential
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling
GO:0097718 disordered domain specific binding
GO:0099111 microtubule-based transport
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0140115 export across plasma membrane
GO:1901164 negative regulation of trophoblast cell migration
GO:1903763 gap junction channel activity involved in cell communication by electrical coupling
GO:1904646 cellular response to amyloid-beta
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905332 positive regulation of morphogenesis of an epithelium
GO:1905772 positive regulation of mesodermal cell differentiation
GO:1905867 epididymis development
GO:2000279 negative regulation of DNA biosynthetic process
GO:2000648 positive regulation of stem cell proliferation
GO:2000810 regulation of bicellular tight junction assembly
GO:2000987 positive regulation of behavioral fear response

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000500 ConnexinFamilyFamily
IPR002261 Gap junction alpha-1 protein (Cx43)FamilyFamily
IPR013092 Connexin, N-terminalDomainDomain
IPR013124 Gap junction alpha-1 protein (Cx43), C-terminalDomainDomain
IPR017990 Connexin, conserved siteSiteConserved site
IPR019570 Gap junction protein, cysteine-rich domainDomainDomain
IPR034634 Connexin, C-terminalFamilyHomologous superfamily
IPR035091 Gap junction alpha-1 protein (Cx43), alpha helix domain superfamilyFamilyHomologous superfamily
IPR038359 Connexin, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01136 CarvedilolDrugbanksmall molecule

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
CXA1_HUMANCSK_HUMANHPRD, MINT11035005 details
CXA1_HUMANZO1_HUMANBioGRID, HPRD, IntAct, MINT16944923 9707407 details
CXA1_HUMANPLPP4_HUMANBioGRID, IntAct32296183 details
CXA1_HUMANNINJ2_HUMANBioGRID, IntAct32296183 details
CXA1_HUMANTM86B_HUMANBioGRID, IntAct32296183 details
CXA1_HUMANTM128_HUMANBioGRID, IntAct32296183 details
CXA1_HUMANCREB3_HUMANBioGRID, IntAct25910212 31515488 details
CXA1_HUMAN5HT2C_HUMANBioGRID, MINT28298427 details
CXA1_HUMANARFG3_HUMANBioGRID, IntAct32814053 34079125 details
CXA1_HUMANKC1D_HUMANBioGRID, HPRD, IntAct12270943 32814053 details
CXA1_HUMANCA216_HUMANIntAct32814053 details
CXA1_HUMANS10A1_HUMANBioGRID, HPRD12804600 details
CXA1_HUMANMK07_HUMANBioGRID, HPRD12637502 8631994 9535905 9535909 details
CXA1_HUMANCAV1_HUMANBioGRID, HPRD11980479 34079125 details
CXA1_HUMANUBQL4_HUMANBioGRID18079109 20940304 24256120 25583071 details
CXA1_HUMANCNST_HUMANBioGRID19864490 details
CXA1_HUMANAKT1_HUMANBioGRID29931708 details
CXA1_HUMANMK01_HUMANBioGRID, HPRD12637502 29931708 8631994 9535905 9535909 details
CXA1_HUMANGBRAP_HUMANBioGRID32272685 details
CXA1_HUMANSGSM3_HUMANHPRD15709751 details
CXA1_HUMANSRC_HUMANHPRD, MINT11035005 11514593 9278444 details
CXA1_HUMANTFCP2_HUMANIntAct20195357 details
CXA1_HUMANDSC2_HUMANBioGRID, IntAct21220045 34079125 details
CXA1_HUMANELP3_HUMANIntAct28507509 details
CXA1_HUMANCXA1_HUMANBioGRID11739633 details
CXA1_HUMANCXA3_HUMANBioGRID, HPRD11739633 details
CXA1_HUMANCXA5_HUMANBioGRID, HPRD11557558 details
CXA1_HUMANKPCA_HUMANBioGRID, HPRD10871288 11273731 details
CXA1_HUMANKPCE_HUMANBioGRID, HPRD10679481 details
CXA1_HUMANNEDD4_HUMANBioGRID19835873 19907029 32272685 details
CXA1_HUMANHGS_HUMANBioGRID19808888 34079125 details
CXA1_HUMANTS101_HUMANBioGRID19808888 details
CXA1_HUMANEPS15_HUMANBioGRID19835873 21554242 25070368 34079125 details
CXA1_HUMANPSMD2_HUMANBioGRID24256120 details
CXA1_HUMANPSMD4_HUMANBioGRID24256120 details
CXA1_HUMANSTABP_HUMANBioGRID25070368 details
CXA1_HUMAN1433T_HUMANBioGRID17008717 details
CXA1_HUMAN1433Z_HUMANBioGRID17008717 details
CXA1_HUMANUBP8_HUMANBioGRID29626091 34079125 details
CXA1_HUMANA16L1_HUMANBioGRID24705551 details
CXA1_HUMANCLH1_HUMANBioGRID24705551 details
CXA1_HUMANATG5_HUMANBioGRID24705551 details
CXA1_HUMANBECN1_HUMANBioGRID24705551 details
CXA1_HUMANPK3C3_HUMANBioGRID24705551 details
CXA1_HUMANPI3R4_HUMANBioGRID24705551 details
CXA1_HUMANBAKOR_HUMANBioGRID24705551 details
CXA1_HUMANMLP3B_HUMANBioGRID32272685 details
CXA1_HUMANSQSTM_HUMANBioGRID32272685 details
CXA1_HUMANCCN3_HUMANHPRD15181016 details
CXA1_HUMANKPCB_HUMANHPRD10871288 details
CXA1_HUMANKPCG_HUMANHPRD10871288 details
CXA1_HUMANMK03_HUMANHPRD12637502 8631994 9535905 9535909 details