Entity Details

Primary name AK1C4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17516
EntryNameAK1C4_HUMAN
FullNameAldo-keto reductase family 1 member C4
TaxID9606
Evidenceevidence at protein level
Length323
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesAKR1C4

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0001758 retinal dehydrogenase activity
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0004033 aldo-keto reductase (NADP) activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006693 prostaglandin metabolic process
GO:0006699 bile acid biosynthetic process
GO:0008202 steroid metabolic process
GO:0008209 androgen metabolic process
GO:0009055 electron transfer activity
GO:0015125 bile acid transmembrane transporter activity
GO:0015721 bile acid and bile salt transport
GO:0016229 steroid dehydrogenase activity
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0032052 bile acid binding
GO:0035410 dihydrotestosterone 17-beta-dehydrogenase activity
GO:0042448 progesterone metabolic process
GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0047023 androsterone dehydrogenase activity
GO:0047024 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047086 ketosteroid monooxygenase activity
GO:0047743 chlordecone reductase activity
GO:0047834 D-threo-aldose 1-dehydrogenase activity
GO:0070062 extracellular exosome
GO:0071395 cellular response to jasmonic acid stimulus
GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR018170 Aldo/keto reductase, conserved siteSiteConserved site
IPR020471 Aldo-keto reductaseFamilyFamily
IPR023210 NADP-dependent oxidoreductase domainDomainDomain
IPR036812 NADP-dependent oxidoreductase domain superfamilyFamilyHomologous superfamily
IPR044482 Aldo-keto reductase family 1 member CFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00461 NabumetoneDrugbanksmall molecule
DB00717 NorethisteroneDrugbanksmall molecule
DB00776 OxcarbazepineDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule

Interactions

0 interactions

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