Entity Details

Primary name LOX12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18054
EntryNameLOX12_HUMAN
FullNamePolyunsaturated fatty acid lipoxygenase ALOX12
TaxID9606
Evidenceevidence at protein level
Length663
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesALOX12

GO terms

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GOName
GO:0004052 arachidonate 12(S)-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006629 lipid metabolic process
GO:0007568 aging
GO:0010628 positive regulation of gene expression
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0016020 membrane
GO:0016165 linoleate 13S-lipoxygenase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0019395 fatty acid oxidation
GO:0033559 unsaturated fatty acid metabolic process
GO:0034440 lipid oxidation
GO:0042383 sarcolemma
GO:0042554 superoxide anion generation
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043651 linoleic acid metabolic process
GO:0047977 hepoxilin-epoxide hydrolase activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050473 arachidonate 15-lipoxygenase activity
GO:0051121 hepoxilin metabolic process
GO:0051122 hepoxilin biosynthetic process
GO:0051901 positive regulation of mitochondrial depolarization
GO:0061436 establishment of skin barrier
GO:0070062 extracellular exosome
GO:0071396 cellular response to lipid
GO:0090331 negative regulation of platelet aggregation
GO:1901751 leukotriene A4 metabolic process
GO:1905956 positive regulation of endothelial tube morphogenesis
GO:2001301 lipoxin biosynthetic process
GO:2001303 lipoxin A4 biosynthetic process
GO:2001306 lipoxin B4 biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000907 LipoxygenaseFamilyFamily
IPR001024 PLAT/LH2 domainDomainDomain
IPR001885 Lipoxygenase, mammalianFamilyFamily
IPR013819 Lipoxygenase, C-terminalDomainDomain
IPR020833 Lipoxygenase, iron binding siteSiteBinding site
IPR020834 Lipoxygenase, conserved siteSiteConserved site
IPR036226 Lipoxigenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036392 PLAT/LH2 domain superfamilyFamilyHomologous superfamily
IPR042062 Lipoxygenase, vertebrates, PLAT domainDomainDomain

Diseases

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Disease IDSourceNameDescription
114500 OMIMColorectal cancer (CRC)A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Disease susceptibility may be associated with variants affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to colorectal cancer (PubMed:17460548).
133239 OMIMEsophageal cancer (ESCR)A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Disease susceptibility may be associated with variants affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to esophageal cancer (PubMed:17460548).